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- W2137278233 abstract "RNA editing at the Q/R site in the GluR5 and GluR6 subunits of neuronal kainate receptors regulates channel inhibition by lipid-derived modulators including the cis-unsaturated fatty acids arachidonic acid and docosahexaenoic acid. Kainate receptor channels in which all of the subunits are in the edited (R) form exhibit strong inhibition by these compounds, whereas wild-type receptors that include a glutamine (Q) at the Q/R site in one or more subunits are resistant to inhibition. In the present study, we have performed an arginine scan of residues in the pore loop of the GluR6(Q) subunit. Amino acids within the range from −19 to +7 of the Q/R site of GluR6(Q) were individually mutated to arginine and the mutant cDNAs were expressed as homomeric channels in HEK 293 cells. All but one of the single arginine substitution mutants yielded functional channels. Only weak inhibition, typical of wild-type GluR6(Q) channels, was observed for substitutions +1 to +6 downstream of the Q/R site. However, arginine substitution at several locations upstream of the Q/R site resulted in homomeric channels exhibiting strong inhibition by fatty acids, which is characteristic of homomeric GluR6(R) channels. Based on homology with the pore loop of potassium channels, locations at which R substitution induces susceptibility to fatty acid inhibition face away from the cytoplasm toward the M1 and M3 helices and surrounding lipids." @default.
- W2137278233 created "2016-06-24" @default.
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- W2137278233 date "2008-06-18" @default.
- W2137278233 modified "2023-09-27" @default.
- W2137278233 title "Amino Acid Substitutions in the Pore Helix of GluR6 Control Inhibition by Membrane Fatty Acids" @default.
- W2137278233 cites W134827746 @default.
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- W2137278233 cites W1549420856 @default.
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- W2137278233 cites W1908222510 @default.
- W2137278233 cites W1969129798 @default.
- W2137278233 cites W1971402629 @default.
- W2137278233 cites W1972859890 @default.
- W2137278233 cites W1975284825 @default.
- W2137278233 cites W1975483893 @default.
- W2137278233 cites W1976833324 @default.
- W2137278233 cites W1977529115 @default.
- W2137278233 cites W1984528002 @default.
- W2137278233 cites W1990625157 @default.
- W2137278233 cites W1996790531 @default.
- W2137278233 cites W2000610579 @default.
- W2137278233 cites W2002302770 @default.
- W2137278233 cites W2002360326 @default.
- W2137278233 cites W2003685112 @default.
- W2137278233 cites W2004369089 @default.
- W2137278233 cites W2005496553 @default.
- W2137278233 cites W2007665141 @default.
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- W2137278233 cites W2033896868 @default.
- W2137278233 cites W2034857163 @default.
- W2137278233 cites W2034961929 @default.
- W2137278233 cites W2038827150 @default.
- W2137278233 cites W2040720735 @default.
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- W2137278233 doi "https://doi.org/10.1085/jgp.200810009" @default.
- W2137278233 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2442176" @default.
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