FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137278319> ?p ?o ?g. }

• W2137278319 endingPage "896" @default.
• W2137278319 startingPage "885" @default.
• W2137278319 abstract "Expression of type IV pili by Neisseria gonorrhoeae plays a critical role in mediating adherence to human epithelial cells. Gonococcal pilin is modified with an O-linked glycan, which may be present as a di- or monosaccharide because of phase variation of select pilin glycosylation genes. It is accepted that bacterial proteins may be glycosylated; less clear is how the protein glycan may mediate virulence. Using primary, human, cervical epithelial (i.e. pex) cells, we now provide evidence to indicate that the pilin glycan mediates productive cervical infection. In this regard, pilin glycan-deficient mutant gonococci exhibited an early hyper-adhesive phenotype but were attenuated in their ability to invade pex cells. Our data further indicate that the pilin glycan was required for gonococci to bind to the I-domain region of complement receptor 3, which is naturally expressed by pex cells. Comparative, quantitative, infection assays revealed that mutant gonococci lacking the pilin glycan did not bind to the I-domain when it is in a closed, low-affinity conformation and cannot induce an active conformation to complement receptor 3 during pex cell challenge. To our knowledge, these are the first data to directly demonstrate how a protein-associated bacterial glycan may contribute to pathogenesis." @default.
• W2137278319 created "2016-06-24" @default.
• W2137278319 creator A5006090545 @default.
• W2137278319 creator A5011648165 @default.
• W2137278319 creator A5087484267 @default.
• W2137278319 creator A5088301120 @default.
• W2137278319 creator A5091646845 @default.
• W2137278319 date "2011-03-04" @default.
• W2137278319 modified "2023-10-02" @default.
• W2137278319 title "Neisseria gonorrhoeae pilin glycan contributes to CR3 activation during challenge of primary cervical epithelial cells" @default.
• W2137278319 cites W1482720254 @default.
• W2137278319 cites W1504989678 @default.
• W2137278319 cites W1531518952 @default.
• W2137278319 cites W1539838410 @default.
• W2137278319 cites W1560567906 @default.
• W2137278319 cites W1568633684 @default.
• W2137278319 cites W1580675778 @default.
• W2137278319 cites W1823124840 @default.
• W2137278319 cites W1870821117 @default.
• W2137278319 cites W1965043002 @default.
• W2137278319 cites W1965841931 @default.
• W2137278319 cites W1969424681 @default.
• W2137278319 cites W1978708058 @default.
• W2137278319 cites W1979467311 @default.
• W2137278319 cites W1988299153 @default.
• W2137278319 cites W1990387345 @default.
• W2137278319 cites W1996372781 @default.
• W2137278319 cites W1998677332 @default.
• W2137278319 cites W2010397566 @default.
• W2137278319 cites W2014443935 @default.
• W2137278319 cites W2019500447 @default.
• W2137278319 cites W2020397881 @default.
• W2137278319 cites W2021410910 @default.
• W2137278319 cites W2028575077 @default.
• W2137278319 cites W2028913667 @default.
• W2137278319 cites W2034694764 @default.
• W2137278319 cites W2040064814 @default.
• W2137278319 cites W2040759607 @default.
• W2137278319 cites W2044326172 @default.
• W2137278319 cites W2050731818 @default.
• W2137278319 cites W2052643656 @default.
• W2137278319 cites W2053001031 @default.
• W2137278319 cites W2059480255 @default.
• W2137278319 cites W2063243999 @default.
• W2137278319 cites W2070429561 @default.
• W2137278319 cites W2079865278 @default.
• W2137278319 cites W2092820810 @default.
• W2137278319 cites W2094570110 @default.
• W2137278319 cites W2094690526 @default.
• W2137278319 cites W2094696847 @default.
• W2137278319 cites W2095730944 @default.
• W2137278319 cites W2103434726 @default.
• W2137278319 cites W2105021118 @default.
• W2137278319 cites W2105177933 @default.
• W2137278319 cites W2117392684 @default.
• W2137278319 cites W2129098607 @default.
• W2137278319 cites W2129920341 @default.
• W2137278319 cites W2130175400 @default.
• W2137278319 cites W2136969158 @default.
• W2137278319 cites W2137758157 @default.
• W2137278319 cites W2140202433 @default.
• W2137278319 cites W2141500155 @default.
• W2137278319 cites W2152881938 @default.
• W2137278319 cites W2158393822 @default.
• W2137278319 cites W2162758710 @default.
• W2137278319 cites W2167870198 @default.
• W2137278319 cites W2169169396 @default.
• W2137278319 cites W2170499630 @default.
• W2137278319 cites W2411768910 @default.
• W2137278319 cites W3880031 @default.
• W2137278319 cites W4212784685 @default.
• W2137278319 cites W4234412959 @default.
• W2137278319 doi "https://doi.org/10.1111/j.1462-5822.2011.01586.x" @default.
• W2137278319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3889163" @default.
• W2137278319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21371235" @default.
• W2137278319 hasPublicationYear "2011" @default.
• W2137278319 type Work @default.
• W2137278319 sameAs 2137278319 @default.
• W2137278319 citedByCount "69" @default.
• W2137278319 countsByYear W21372783192012 @default.
• W2137278319 countsByYear W21372783192013 @default.
• W2137278319 countsByYear W21372783192014 @default.
• W2137278319 countsByYear W21372783192015 @default.
• W2137278319 countsByYear W21372783192016 @default.
• W2137278319 countsByYear W21372783192017 @default.
• W2137278319 countsByYear W21372783192018 @default.
• W2137278319 countsByYear W21372783192019 @default.
• W2137278319 countsByYear W21372783192020 @default.
• W2137278319 countsByYear W21372783192021 @default.
• W2137278319 countsByYear W21372783192022 @default.
• W2137278319 countsByYear W21372783192023 @default.
• W2137278319 crossrefType "journal-article" @default.
• W2137278319 hasAuthorship W2137278319A5006090545 @default.
• W2137278319 hasAuthorship W2137278319A5011648165 @default.
• W2137278319 hasAuthorship W2137278319A5087484267 @default.
• W2137278319 hasAuthorship W2137278319A5088301120 @default.
• W2137278319 hasAuthorship W2137278319A5091646845 @default.
• W2137278319 hasBestOaLocation W21372783192 @default.

• next