FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137285938> ?p ?o ?g. }

• W2137285938 endingPage "873" @default.
• W2137285938 startingPage "853" @default.
• W2137285938 abstract "Nanoparticles are increasingly being incorporated into the design of diagnostic imaging agents. Significant research efforts have been conducted with one class of lipid nanoparticle (liposomes) radiolabeled with gamma-emitting radionuclides as radiopharmaceuticals for scintigraphic imaging of cancer, inflammation/infection and sentinel lymph node detection.This article reviews the current literature with special emphasis on the clinical studies performed with liposome radiopharmaceuticals for detection of tumors, infectious/inflammatory sites or metastatic lymph nodes. Future uses of liposome radiopharmaceuticals are also described.Characteristics required of the radionuclide, liposome formulation and radiolabeling method for an effective radiopharmaceutical are discussed. A description of the procedures and instrumentation for conducting an imaging study with liposome radiopharmaceutical is included. Clinical studies using liposome radiopharmaceuticals are summarized. Future imaging applications of first- and second-generation radiolabeled liposomes for chemodosimetry and the specific targeting of a disease process are also described.The choice of radionuclide, liposome formulation and radiolabeling method must be carefully considered during the design of a liposome radiopharmaceutical for a given application. After-loading and surface chelation methods are the most efficient and practical. Clinical studies with liposome radiopharmaceuticals demonstrated that a wide variety of tumors could be detected with good sensitivity and specificity. Liposome radiopharmaceuticals could also clearly detect various soft tissue and bone inflammatory/infectious lesions, and performed equal to or better than infection imaging agents that are approved at present. Yet, despite these favorable results, no liposome radiopharmaceutical has been approved for any indication. Some of the reasons for this can be attributed to reports of an unexpected infusion-related adverse reaction in two studies, the requirement of more complex liposome manufacturing procedures, and the adoption of other competing imaging procedures. Continued research of liposome radiopharmaceutical design based on a better understanding of liposome biology, improved radiolabeling methodologies and advances in gamma camera technology is warranted." @default.
• W2137285938 created "2016-06-24" @default.
• W2137285938 creator A5054573497 @default.
• W2137285938 date "2008-07-01" @default.
• W2137285938 modified "2023-10-18" @default.
• W2137285938 title "Radiolabeled lipid nanoparticles for diagnostic imaging" @default.
• W2137285938 cites W13520342 @default.
• W2137285938 cites W1527313350 @default.
• W2137285938 cites W1533253593 @default.
• W2137285938 cites W1567015072 @default.
• W2137285938 cites W1596131832 @default.
• W2137285938 cites W1646035593 @default.
• W2137285938 cites W1931360860 @default.
• W2137285938 cites W1942565668 @default.
• W2137285938 cites W1963655497 @default.
• W2137285938 cites W1970239046 @default.
• W2137285938 cites W1970855558 @default.
• W2137285938 cites W1972703248 @default.
• W2137285938 cites W1972862586 @default.
• W2137285938 cites W1974242571 @default.
• W2137285938 cites W1974822561 @default.
• W2137285938 cites W1980684851 @default.
• W2137285938 cites W1981769007 @default.
• W2137285938 cites W1981856846 @default.
• W2137285938 cites W1982033806 @default.
• W2137285938 cites W1982904375 @default.
• W2137285938 cites W1983229320 @default.
• W2137285938 cites W1984245313 @default.
• W2137285938 cites W1991295924 @default.
• W2137285938 cites W1995102405 @default.
• W2137285938 cites W1996517371 @default.
• W2137285938 cites W1999416810 @default.
• W2137285938 cites W1999607536 @default.
• W2137285938 cites W2001684619 @default.
• W2137285938 cites W2002899996 @default.
• W2137285938 cites W2003252564 @default.
• W2137285938 cites W2003966449 @default.
• W2137285938 cites W2008538485 @default.
• W2137285938 cites W2009030169 @default.
• W2137285938 cites W2009303467 @default.
• W2137285938 cites W2009426961 @default.
• W2137285938 cites W2011891975 @default.
• W2137285938 cites W2013470095 @default.
• W2137285938 cites W2013942895 @default.
• W2137285938 cites W2014921179 @default.
• W2137285938 cites W2015230924 @default.
• W2137285938 cites W2015279385 @default.
• W2137285938 cites W2021367421 @default.
• W2137285938 cites W2023038619 @default.
• W2137285938 cites W2023161586 @default.
• W2137285938 cites W2023913853 @default.
• W2137285938 cites W2024962667 @default.
• W2137285938 cites W2025919388 @default.
• W2137285938 cites W2026073350 @default.
• W2137285938 cites W2026322894 @default.
• W2137285938 cites W2028065774 @default.
• W2137285938 cites W2028068697 @default.
• W2137285938 cites W2030652623 @default.
• W2137285938 cites W2031577180 @default.
• W2137285938 cites W2031757543 @default.
• W2137285938 cites W2034986910 @default.
• W2137285938 cites W2036944284 @default.
• W2137285938 cites W2039884231 @default.
• W2137285938 cites W2041020196 @default.
• W2137285938 cites W2041153276 @default.
• W2137285938 cites W2046147369 @default.
• W2137285938 cites W2048053890 @default.
• W2137285938 cites W2048827359 @default.
• W2137285938 cites W2050049641 @default.
• W2137285938 cites W2050824534 @default.
• W2137285938 cites W2052753580 @default.
• W2137285938 cites W2053163969 @default.
• W2137285938 cites W2055425528 @default.
• W2137285938 cites W2059002761 @default.
• W2137285938 cites W2061271429 @default.
• W2137285938 cites W2061510929 @default.
• W2137285938 cites W2064449578 @default.
• W2137285938 cites W2065946609 @default.
• W2137285938 cites W2068111372 @default.
• W2137285938 cites W2068788108 @default.
• W2137285938 cites W2070198605 @default.
• W2137285938 cites W2074062696 @default.
• W2137285938 cites W2074244880 @default.
• W2137285938 cites W2074606827 @default.
• W2137285938 cites W2076687046 @default.
• W2137285938 cites W2078694420 @default.
• W2137285938 cites W2078816993 @default.
• W2137285938 cites W2079358117 @default.
• W2137285938 cites W2080032186 @default.
• W2137285938 cites W2081644568 @default.
• W2137285938 cites W2083843762 @default.
• W2137285938 cites W2084478016 @default.
• W2137285938 cites W2086856055 @default.
• W2137285938 cites W2087020662 @default.
• W2137285938 cites W2089061114 @default.
• W2137285938 cites W2089645494 @default.
• W2137285938 cites W2089820329 @default.
• W2137285938 cites W2089959117 @default.

• next