FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137306592> ?p ?o ?g. }

• W2137306592 endingPage "352" @default.
• W2137306592 startingPage "341" @default.
• W2137306592 abstract "Here we review a novel class of delivery vehicles based on pH-sensitive, moderately polar membrane peptides, which we call pH (Low) Insertion Peptides (pHLIPs), that target cells located in the acidic environment found in many diseased tissues, including tumours. Acidity targeting by pHLIPs is achieved as a result of helix formation and transmembrane insertion. In contrast to the earlier technologies based on cell-penetrating peptides, pHLIPs act as monomeric membrane-inserting peptides that translocate one terminus across a membrane into the cytoplasm, while the other terminus remains in the extracellular space, locating the peptide in the membrane lipid bilayer. Therefore pHLIP has a dual delivery capability: it can tether cargo molecules or nanoparticles to the surfaces of cells in diseased tissues and/or it can move a cell-impermeable cargo molecule across the membrane into the cytoplasm. The source of energy for moving polar molecules attached to pHLIP through the hydrophobic layer of a membrane bilayer is the membrane-associated folding of the polypeptide. A drop in pH leads to the protonation of negatively charged residues (Asp or Glu), which enhances peptide hydrophobicity, increasing the affinity of the peptide for the lipid bilayer and triggering peptide folding and subsequent membrane insertion. The process is accompanied by the release of energy that can be utilized to move cell-impermeable cargo across a membrane. That the mechanism is now understood, and that targeting of tumours in mice has been shown, suggest a number of future applications of the pHLIP technology in the diagnosis and treatment of disease." @default.
• W2137306592 created "2016-06-24" @default.
• W2137306592 creator A5002753770 @default.
• W2137306592 creator A5024730290 @default.
• W2137306592 creator A5029396684 @default.
• W2137306592 date "2010-10-01" @default.
• W2137306592 modified "2023-10-04" @default.
• W2137306592 title "pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents" @default.
• W2137306592 cites W1512026049 @default.
• W2137306592 cites W1521516049 @default.
• W2137306592 cites W1558431302 @default.
• W2137306592 cites W1821779286 @default.
• W2137306592 cites W1966309781 @default.
• W2137306592 cites W1966472904 @default.
• W2137306592 cites W1968751925 @default.
• W2137306592 cites W1969722712 @default.
• W2137306592 cites W1970098138 @default.
• W2137306592 cites W1972154409 @default.
• W2137306592 cites W1975258721 @default.
• W2137306592 cites W1981689158 @default.
• W2137306592 cites W1981888695 @default.
• W2137306592 cites W1985969082 @default.
• W2137306592 cites W1987970382 @default.
• W2137306592 cites W1988286575 @default.
• W2137306592 cites W1988610380 @default.
• W2137306592 cites W1990157927 @default.
• W2137306592 cites W1997388514 @default.
• W2137306592 cites W2002224827 @default.
• W2137306592 cites W2006656525 @default.
• W2137306592 cites W2007037818 @default.
• W2137306592 cites W2010884061 @default.
• W2137306592 cites W2013383215 @default.
• W2137306592 cites W2014452751 @default.
• W2137306592 cites W2018095250 @default.
• W2137306592 cites W2020305814 @default.
• W2137306592 cites W2021074046 @default.
• W2137306592 cites W2024132789 @default.
• W2137306592 cites W2024592141 @default.
• W2137306592 cites W2025587507 @default.
• W2137306592 cites W2027758728 @default.
• W2137306592 cites W2028074588 @default.
• W2137306592 cites W2028999918 @default.
• W2137306592 cites W2029463074 @default.
• W2137306592 cites W2037305018 @default.
• W2137306592 cites W2037785089 @default.
• W2137306592 cites W2041076776 @default.
• W2137306592 cites W2047676254 @default.
• W2137306592 cites W2048110853 @default.
• W2137306592 cites W2048133584 @default.
• W2137306592 cites W2048758535 @default.
• W2137306592 cites W2049341262 @default.
• W2137306592 cites W2050524601 @default.
• W2137306592 cites W2051095530 @default.
• W2137306592 cites W2053390368 @default.
• W2137306592 cites W2054840039 @default.
• W2137306592 cites W2058451329 @default.
• W2137306592 cites W2058460324 @default.
• W2137306592 cites W2064085430 @default.
• W2137306592 cites W2064552416 @default.
• W2137306592 cites W2065100627 @default.
• W2137306592 cites W2065946609 @default.
• W2137306592 cites W2070385942 @default.
• W2137306592 cites W2073726493 @default.
• W2137306592 cites W2073939868 @default.
• W2137306592 cites W2075812658 @default.
• W2137306592 cites W2077654655 @default.
• W2137306592 cites W2078684128 @default.
• W2137306592 cites W2078803304 @default.
• W2137306592 cites W2079826060 @default.
• W2137306592 cites W2082148481 @default.
• W2137306592 cites W2082511916 @default.
• W2137306592 cites W2084235230 @default.
• W2137306592 cites W2085319321 @default.
• W2137306592 cites W2087785909 @default.
• W2137306592 cites W2093828087 @default.
• W2137306592 cites W2096771026 @default.
• W2137306592 cites W2102322990 @default.
• W2137306592 cites W2105390941 @default.
• W2137306592 cites W2107789887 @default.
• W2137306592 cites W2107799535 @default.
• W2137306592 cites W2108623294 @default.
• W2137306592 cites W2109194132 @default.
• W2137306592 cites W2112107625 @default.
• W2137306592 cites W2113101064 @default.
• W2137306592 cites W2122995470 @default.
• W2137306592 cites W2123235879 @default.
• W2137306592 cites W2123670081 @default.
• W2137306592 cites W2127841706 @default.
• W2137306592 cites W2130503287 @default.
• W2137306592 cites W2135732933 @default.
• W2137306592 cites W2136044635 @default.
• W2137306592 cites W2138433877 @default.
• W2137306592 cites W2138875941 @default.
• W2137306592 cites W2142298650 @default.
• W2137306592 cites W2144775514 @default.
• W2137306592 cites W2145213448 @default.
• W2137306592 cites W2145238798 @default.
• W2137306592 cites W2148051205 @default.

• next