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- W2137308839 abstract "Cytokines play a central role in the regulation of immunity and are often found to be deregulated in autoimmune diseases. Sjögren's syndrome is a chronic autoimmune disease characterized by inflammation and loss of secretory function of the salivary and lachrymal glands. This review highlights the current knowledge of the expression and the function of pro- and anti-inflammatory cytokines both locally and systemically in Sjögren's syndrome patients. In the salivary glands, saliva and serum of these patients, many pro-inflammatory cytokines are upregulated. Concomitantly, most anti-inflammatory cytokines are not detectable or are expressed at low levels. Besides a role in inflammation, cytokines are also thought to be involved in salivary gland dysfunction by directly interfering with the epithelial cells in the glands. Future research on the role of novel cytokines in Sjögren's syndrome in combination with a better understanding of the effect of cytokines on exocrine dysfunction will aide the identification of the best therapeutic targets for Sjögren's syndrome." @default.
- W2137308839 created "2016-06-24" @default.
- W2137308839 creator A5012564728 @default.
- W2137308839 creator A5045259317 @default.
- W2137308839 creator A5076613698 @default.
- W2137308839 date "2009-10-07" @default.
- W2137308839 modified "2023-10-18" @default.
- W2137308839 title "Cytokines in Sjögren’s syndrome" @default.
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- W2137308839 doi "https://doi.org/10.1111/j.1601-0825.2009.01582.x" @default.
- W2137308839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2762015" @default.
- W2137308839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19519622" @default.
- W2137308839 hasPublicationYear "2009" @default.
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