Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137357821> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2137357821 endingPage "909" @default.
- W2137357821 startingPage "903" @default.
- W2137357821 abstract "Dipyrone (Dp) delays gastric emptying (GE) in rats. There is no information about whether 4-aminoantipyrine (AA), one of its metabolites, has the same effect. The objectives of the present study were to assess the effects of AA and Dp on GE when administered intravenously (iv) and intracerebroventricularly (icv) (240 micromol/kg and 4 micromol/animal, respectively) and on gastric compliance when administered iv (240 micromol/kg). GE was determined in male Wistar rats weighing 250-300 g (5-10 per group) after icv or iv injection of the drug by measuring percent gastric retention (GR) of a saline meal labeled with phenol red 10 min after administration by gavage. Gastric compliance was estimated in anesthetized rats (10-11 per group), with the construction of volume-pressure curves during intragastric infusion of a saline meal. Compliance was significantly greater in animals receiving Dp (mean +/- SEM = 0.26 +/- 0.009 mL/mmHg) and AA (0.24 +/- 0.012 mL/mmHg) than in controls (0.19 +/- 0.009 mL/mmHg). AA and Dp administered iv significantly increased GR (64.4 +/- 2.5 and 54.3 +/- 3.8%, respectively) compared to control (34 +/- 2.2%), a phenomenon observed only with Dp after icv administration. Subdiaphragmatic vagotomy reduced the effect of AA (GR = 31.4 +/- 1.5%) compared to sham-treated animals. Baclofen, a GABAB receptor agonist, administered icv significantly reduced the effect of AA (GR = 28.1 +/- 1.3%). We conclude that Dp and AA increased gastric compliance and AA delayed GE, with the participation of the vagus nerve, through a pathway that does not involve a direct action of the drug on the central nervous system." @default.
- W2137357821 created "2016-06-24" @default.
- W2137357821 creator A5047956601 @default.
- W2137357821 creator A5061763594 @default.
- W2137357821 date "2007-06-06" @default.
- W2137357821 modified "2023-10-10" @default.
- W2137357821 title "Effect of 4-aminoantipyrine on gastric compliance and liquid emptying in rats" @default.
- W2137357821 cites W1970489631 @default.
- W2137357821 cites W1971178236 @default.
- W2137357821 cites W1977791621 @default.
- W2137357821 cites W2004085235 @default.
- W2137357821 cites W2010304410 @default.
- W2137357821 cites W2024326029 @default.
- W2137357821 cites W2031862633 @default.
- W2137357821 cites W2050836827 @default.
- W2137357821 cites W2053456907 @default.
- W2137357821 cites W2065209479 @default.
- W2137357821 cites W2073029381 @default.
- W2137357821 cites W2083819801 @default.
- W2137357821 cites W2120402737 @default.
- W2137357821 cites W3192351297 @default.
- W2137357821 cites W2122714353 @default.
- W2137357821 doi "https://doi.org/10.1590/s0100-879x2006005000119" @default.
- W2137357821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17653442" @default.
- W2137357821 hasPublicationYear "2007" @default.
- W2137357821 type Work @default.
- W2137357821 sameAs 2137357821 @default.
- W2137357821 citedByCount "18" @default.
- W2137357821 countsByYear W21373578212013 @default.
- W2137357821 countsByYear W21373578212014 @default.
- W2137357821 countsByYear W21373578212015 @default.
- W2137357821 countsByYear W21373578212016 @default.
- W2137357821 countsByYear W21373578212019 @default.
- W2137357821 countsByYear W21373578212021 @default.
- W2137357821 countsByYear W21373578212022 @default.
- W2137357821 crossrefType "journal-article" @default.
- W2137357821 hasAuthorship W2137357821A5047956601 @default.
- W2137357821 hasAuthorship W2137357821A5061763594 @default.
- W2137357821 hasBestOaLocation W21373578211 @default.
- W2137357821 hasConcept C126322002 @default.
- W2137357821 hasConcept C134018914 @default.
- W2137357821 hasConcept C170493617 @default.
- W2137357821 hasConcept C185592680 @default.
- W2137357821 hasConcept C24998067 @default.
- W2137357821 hasConcept C2777397205 @default.
- W2137357821 hasConcept C2778345441 @default.
- W2137357821 hasConcept C2778450494 @default.
- W2137357821 hasConcept C2778720886 @default.
- W2137357821 hasConcept C2778938600 @default.
- W2137357821 hasConcept C2779422922 @default.
- W2137357821 hasConcept C2781404750 @default.
- W2137357821 hasConcept C3020479747 @default.
- W2137357821 hasConcept C42219234 @default.
- W2137357821 hasConcept C43617362 @default.
- W2137357821 hasConcept C71924100 @default.
- W2137357821 hasConceptScore W2137357821C126322002 @default.
- W2137357821 hasConceptScore W2137357821C134018914 @default.
- W2137357821 hasConceptScore W2137357821C170493617 @default.
- W2137357821 hasConceptScore W2137357821C185592680 @default.
- W2137357821 hasConceptScore W2137357821C24998067 @default.
- W2137357821 hasConceptScore W2137357821C2777397205 @default.
- W2137357821 hasConceptScore W2137357821C2778345441 @default.
- W2137357821 hasConceptScore W2137357821C2778450494 @default.
- W2137357821 hasConceptScore W2137357821C2778720886 @default.
- W2137357821 hasConceptScore W2137357821C2778938600 @default.
- W2137357821 hasConceptScore W2137357821C2779422922 @default.
- W2137357821 hasConceptScore W2137357821C2781404750 @default.
- W2137357821 hasConceptScore W2137357821C3020479747 @default.
- W2137357821 hasConceptScore W2137357821C42219234 @default.
- W2137357821 hasConceptScore W2137357821C43617362 @default.
- W2137357821 hasConceptScore W2137357821C71924100 @default.
- W2137357821 hasIssue "7" @default.
- W2137357821 hasLocation W21373578211 @default.
- W2137357821 hasLocation W21373578212 @default.
- W2137357821 hasLocation W21373578213 @default.
- W2137357821 hasOpenAccess W2137357821 @default.
- W2137357821 hasPrimaryLocation W21373578211 @default.
- W2137357821 hasRelatedWork W1789692432 @default.
- W2137357821 hasRelatedWork W1791896453 @default.
- W2137357821 hasRelatedWork W1986799117 @default.
- W2137357821 hasRelatedWork W2008998325 @default.
- W2137357821 hasRelatedWork W2051929309 @default.
- W2137357821 hasRelatedWork W2089915552 @default.
- W2137357821 hasRelatedWork W2137357821 @default.
- W2137357821 hasRelatedWork W2226562228 @default.
- W2137357821 hasRelatedWork W2410801882 @default.
- W2137357821 hasRelatedWork W2415781982 @default.
- W2137357821 hasVolume "40" @default.
- W2137357821 isParatext "false" @default.
- W2137357821 isRetracted "false" @default.
- W2137357821 magId "2137357821" @default.
- W2137357821 workType "article" @default.