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• W2137364006 endingPage "1781" @default.
• W2137364006 startingPage "1765" @default.
• W2137364006 abstract "Activation of the LH receptor (LHR) on preovulatory granulosa cells stimulates the cAMP/protein kinase A (PKA) pathway to regulate expression of genes required for ovulation and luteinization. LHR signaling also initiates rearrangement of the actin cytoskeleton. Because disruption of the actin cytoskeleton has been causally linked to steroidogenesis in various cell models, we sought to identify the cellular mechanisms that may modulate reorganization of the actin cytoskeleton and to determine whether cytoskeletal reorganization is required for steroidogenesis. Herein we report that LHR signaling in preovulatory granulosa cells promotes rapid dephosphorylation of the actin-depolymerizing factor cofilin at Ser3 that is dependent on PKA. The LHR-stimulated dephosphorylation of cofilin(Ser3) switches on cofilin activity to bind actin filaments and enhance their dynamics. Basal phosphorylation of cofilin(Ser3) is mediated by active/GTP-bound Rho and downstream protein kinases; LHR signaling promotes a decrease in active/GTP-bound Rho by a PKA-dependent mechanism. LHR-dependent Rho inactivation and subsequent activation of cofilin does not involve ERK, epidermal growth factor receptor, or phosphatidylinositol 3-kinase pathways downstream of PKA. To understand the biological significance of cofilin activation, preovulatory granulosa cells were transduced with a mutant cofilin adenoviral vector in which Ser3 was mutated to Glu (S-E cofilin). Inactive S-E cofilin abolished LHR-mediated reorganization of the actin cytoskeleton and caused a 70% decrease in LHR-stimulated progesterone that is obligatory for ovulation. Taken together, these results show that LHR signaling via PKA activates a cofilin-regulated rearrangement of the actin cytoskeleton and that active cofilin is required to initiate progesterone secretion by preovulatory granulosa cells." @default.
• W2137364006 created "2016-06-24" @default.
• W2137364006 creator A5035402807 @default.
• W2137364006 creator A5037833467 @default.
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• W2137364006 creator A5077623227 @default.
• W2137364006 creator A5088598466 @default.
• W2137364006 creator A5090777952 @default.
• W2137364006 date "2010-09-01" @default.
• W2137364006 modified "2023-09-25" @default.
• W2137364006 title "Luteinizing Hormone Receptor-Stimulated Progesterone Production by Preovulatory Granulosa Cells Requires Protein Kinase A-Dependent Activation/Dephosphorylation of the Actin Dynamizing Protein Cofilin" @default.
• W2137364006 cites W1236053900 @default.
• W2137364006 cites W1492344127 @default.
• W2137364006 cites W1541370757 @default.
• W2137364006 cites W1560179018 @default.
• W2137364006 cites W1564176844 @default.
• W2137364006 cites W1765820548 @default.
• W2137364006 cites W1775749144 @default.
• W2137364006 cites W1841826782 @default.
• W2137364006 cites W1885709862 @default.
• W2137364006 cites W1916799666 @default.
• W2137364006 cites W1966541444 @default.
• W2137364006 cites W1969024223 @default.
• W2137364006 cites W1973655801 @default.
• W2137364006 cites W1976100793 @default.
• W2137364006 cites W1984559046 @default.
• W2137364006 cites W1987945086 @default.
• W2137364006 cites W1988687951 @default.
• W2137364006 cites W1989772312 @default.
• W2137364006 cites W1990375473 @default.
• W2137364006 cites W1993195482 @default.
• W2137364006 cites W1998894432 @default.
• W2137364006 cites W1999924432 @default.
• W2137364006 cites W2001678988 @default.
• W2137364006 cites W2004805723 @default.
• W2137364006 cites W2006990725 @default.
• W2137364006 cites W2013576879 @default.
• W2137364006 cites W2016494759 @default.
• W2137364006 cites W2022726449 @default.
• W2137364006 cites W2026771277 @default.
• W2137364006 cites W2031429450 @default.
• W2137364006 cites W2031512686 @default.
• W2137364006 cites W2032703616 @default.
• W2137364006 cites W2032842750 @default.
• W2137364006 cites W2034877305 @default.
• W2137364006 cites W2037367943 @default.
• W2137364006 cites W2039486449 @default.
• W2137364006 cites W2039723960 @default.
• W2137364006 cites W2041655797 @default.
• W2137364006 cites W2041744828 @default.
• W2137364006 cites W2042945898 @default.
• W2137364006 cites W2044138206 @default.
• W2137364006 cites W2046812435 @default.
• W2137364006 cites W2046822015 @default.
• W2137364006 cites W2046919271 @default.
• W2137364006 cites W2047083811 @default.
• W2137364006 cites W2047106939 @default.
• W2137364006 cites W2048243564 @default.
• W2137364006 cites W2048774799 @default.
• W2137364006 cites W2051254316 @default.
• W2137364006 cites W2055430160 @default.
• W2137364006 cites W2057539921 @default.
• W2137364006 cites W2058374230 @default.
• W2137364006 cites W2059273534 @default.
• W2137364006 cites W2062745430 @default.
• W2137364006 cites W2063065938 @default.
• W2137364006 cites W2072706075 @default.
• W2137364006 cites W2074867744 @default.
• W2137364006 cites W2075018754 @default.
• W2137364006 cites W2076500432 @default.
• W2137364006 cites W2077476601 @default.
• W2137364006 cites W2078037416 @default.
• W2137364006 cites W2079902170 @default.
• W2137364006 cites W2082559087 @default.
• W2137364006 cites W2084172300 @default.
• W2137364006 cites W2086121206 @default.
• W2137364006 cites W2088390218 @default.
• W2137364006 cites W2089408085 @default.
• W2137364006 cites W2089727050 @default.
• W2137364006 cites W2097621912 @default.
• W2137364006 cites W2098429514 @default.
• W2137364006 cites W2099987623 @default.
• W2137364006 cites W2101176536 @default.
• W2137364006 cites W2102312968 @default.
• W2137364006 cites W2104241104 @default.
• W2137364006 cites W2107584289 @default.
• W2137364006 cites W2111355903 @default.
• W2137364006 cites W2115651547 @default.
• W2137364006 cites W2116671711 @default.
• W2137364006 cites W2117297645 @default.
• W2137364006 cites W2124856535 @default.
• W2137364006 cites W2125206070 @default.
• W2137364006 cites W2125415514 @default.
• W2137364006 cites W2128148740 @default.
• W2137364006 cites W2133537430 @default.
• W2137364006 cites W2142685635 @default.
• W2137364006 cites W2143563119 @default.

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