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• W2137388630 abstract "Parkinson's disease (PD) is a progressive neurodegenerative disease. Alpha-synuclein aggregation, which can activate microglia to enhance its dopaminergic neurotoxicity, plays a central role in the progression of PD. However the mechanism is still unclear. To investigate how alpha-synuclein affects the neuron, exosomes were derived from alpha-synuclein treated mouse microglia cell line BV-2 cells by differential centrifugation and ultracentrifugation. We found that alpha-synuclein can induce an increase of exosomal secretion by microglia. These activated exosomes expressed a high level of MHC class II molecules and membrane TNF-α. In addition, the activated exosomes cause increased apoptosis. Exosomes secreted from activated microglias might be important mediator of alpha-synuclein-induced neurodegeneration in PD." @default.
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• W2137388630 date "2013-08-01" @default.
• W2137388630 modified "2023-09-30" @default.
• W2137388630 title "Exosomes of BV-2 cells induced by alpha-synuclein: Important mediator of neurodegeneration in PD" @default.
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• W2137388630 doi "https://doi.org/10.1016/j.neulet.2013.06.009" @default.
• W2137388630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23792198" @default.
• W2137388630 hasPublicationYear "2013" @default.
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