FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137390717> ?p ?o ?g. }

• W2137390717 endingPage "55" @default.
• W2137390717 startingPage "7345" @default.
• W2137390717 abstract "The c-Met receptor tyrosine kinase and its ligand, hepatocyte growth factor (HGF), have been implicated in the development and progression of several human cancers and are attractive targets for cancer therapy. PHA-665752 was identified as a small molecule, ATP-competitive, active-site inhibitor of the catalytic activity of c-Met kinase (K(i) 4 nM). PHA-665752 also exhibited >50-fold selectivity for c-Met compared with a panel of diverse tyrosine and serine-threonine kinases. In cellular studies, PHA-665752 potently inhibited HGF-stimulated and constitutive c-Met phosphorylation, as well as HGF and c-Met-driven phenotypes such as cell growth (proliferation and survival), cell motility, invasion, and/or morphology of a variety of tumor cells. In addition, PHA-665752 inhibited HGF-stimulated or constitutive phosphorylation of mediators of downstream signal transduction of c-Met, including Gab-1, extracellular regulated kinase, Akt, signal transducer and activator of transcription 3, phospholipase C gamma, and focal adhesion kinase, in multiple tumor cell lines in a pattern correlating to the phenotypic response of a given tumor cell. In in vivo studies, a single dose of PHA-665752 inhibited c-Met phosphorylation in tumor xenografts for up to 12 h. Inhibition of c-Met phosphorylation was associated with dose-dependent tumor growth inhibition/growth delay over a repeated administration schedule at well-tolerated doses. Interestingly, potent cytoreductive activity was demonstrated in a gastric carcinoma xenograft model. Collectively, these results demonstrate the feasibility of selectively targeting c-Met with ATP-competitive small-molecules and suggest the therapeutic potential of targeting c-Met in human cancers." @default.
• W2137390717 created "2016-06-24" @default.
• W2137390717 creator A5014875856 @default.
• W2137390717 creator A5023261189 @default.
• W2137390717 creator A5035307605 @default.
• W2137390717 creator A5036437571 @default.
• W2137390717 creator A5040992537 @default.
• W2137390717 creator A5044900701 @default.
• W2137390717 creator A5045957422 @default.
• W2137390717 creator A5046069538 @default.
• W2137390717 creator A5052616905 @default.
• W2137390717 creator A5060596240 @default.
• W2137390717 creator A5072570750 @default.
• W2137390717 creator A5072863214 @default.
• W2137390717 creator A5073316865 @default.
• W2137390717 creator A5074923974 @default.
• W2137390717 creator A5078774955 @default.
• W2137390717 creator A5085988623 @default.
• W2137390717 date "2003-11-01" @default.
• W2137390717 modified "2023-10-13" @default.
• W2137390717 title "A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo." @default.
• W2137390717 cites W117902596 @default.
• W2137390717 cites W1261881945 @default.
• W2137390717 cites W1263733664 @default.
• W2137390717 cites W1506256987 @default.
• W2137390717 cites W1577036237 @default.
• W2137390717 cites W1649526546 @default.
• W2137390717 cites W1928129824 @default.
• W2137390717 cites W1972607682 @default.
• W2137390717 cites W1973966923 @default.
• W2137390717 cites W1985562847 @default.
• W2137390717 cites W1995862211 @default.
• W2137390717 cites W2005092992 @default.
• W2137390717 cites W2007904495 @default.
• W2137390717 cites W2007941427 @default.
• W2137390717 cites W2012792646 @default.
• W2137390717 cites W2014105735 @default.
• W2137390717 cites W2018672261 @default.
• W2137390717 cites W2019573100 @default.
• W2137390717 cites W2021452013 @default.
• W2137390717 cites W2022527563 @default.
• W2137390717 cites W2023586869 @default.
• W2137390717 cites W2030410158 @default.
• W2137390717 cites W2042323503 @default.
• W2137390717 cites W2042919832 @default.
• W2137390717 cites W2048097275 @default.
• W2137390717 cites W2048613455 @default.
• W2137390717 cites W2049759529 @default.
• W2137390717 cites W2054042846 @default.
• W2137390717 cites W2059950450 @default.
• W2137390717 cites W2067297743 @default.
• W2137390717 cites W2075081031 @default.
• W2137390717 cites W2087352606 @default.
• W2137390717 cites W2093999584 @default.
• W2137390717 cites W2101774275 @default.
• W2137390717 cites W2113045327 @default.
• W2137390717 cites W2121371052 @default.
• W2137390717 cites W2121571446 @default.
• W2137390717 cites W2132755748 @default.
• W2137390717 cites W2134755472 @default.
• W2137390717 cites W2139440398 @default.
• W2137390717 cites W2143984112 @default.
• W2137390717 cites W2149902890 @default.
• W2137390717 cites W2151812232 @default.
• W2137390717 cites W2166927748 @default.
• W2137390717 cites W2323767042 @default.
• W2137390717 cites W2328693672 @default.
• W2137390717 cites W2330176638 @default.
• W2137390717 cites W2406276138 @default.
• W2137390717 cites W83231304 @default.
• W2137390717 cites W86262156 @default.
• W2137390717 cites W90465349 @default.
• W2137390717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14612533" @default.
• W2137390717 hasPublicationYear "2003" @default.
• W2137390717 type Work @default.
• W2137390717 sameAs 2137390717 @default.
• W2137390717 citedByCount "119" @default.
• W2137390717 countsByYear W21373907172012 @default.
• W2137390717 countsByYear W21373907172013 @default.
• W2137390717 countsByYear W21373907172014 @default.
• W2137390717 countsByYear W21373907172015 @default.
• W2137390717 countsByYear W21373907172016 @default.
• W2137390717 countsByYear W21373907172017 @default.
• W2137390717 countsByYear W21373907172018 @default.
• W2137390717 countsByYear W21373907172019 @default.
• W2137390717 countsByYear W21373907172020 @default.
• W2137390717 countsByYear W21373907172021 @default.
• W2137390717 countsByYear W21373907172022 @default.
• W2137390717 countsByYear W21373907172023 @default.
• W2137390717 crossrefType "journal-article" @default.
• W2137390717 hasAuthorship W2137390717A5014875856 @default.
• W2137390717 hasAuthorship W2137390717A5023261189 @default.
• W2137390717 hasAuthorship W2137390717A5035307605 @default.
• W2137390717 hasAuthorship W2137390717A5036437571 @default.
• W2137390717 hasAuthorship W2137390717A5040992537 @default.
• W2137390717 hasAuthorship W2137390717A5044900701 @default.
• W2137390717 hasAuthorship W2137390717A5045957422 @default.
• W2137390717 hasAuthorship W2137390717A5046069538 @default.

• next