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- W2137395087 startingPage "83" @default.
- W2137395087 abstract "Multiple types of indirect evidence have been used to support theories of altered cortical connectivity in autism spectrum disorders (ASD). In other developmental disorders reduced spine expression is commonly found, while conditions such as fragile X syndrome show increased spine densities. Despite its relevance to theories of altered cortical connectivity, synaptic spine expression has not been systematically explored in ASD. Here we examine dendritic spines on Golgi-impregnated cortical pyramidal cells in the cortex of ASD subjects and age-matched control cases. Pyramidal cells were studied within both the superficial and deep cortical layers of frontal, temporal, and parietal lobe regions. Relative to controls, spine densities were greater in ASD subjects. In analyses restricted to the apical dendrites of pyramidal cells, greater spine densities were found predominantly within layer II of each cortical location and within layer V of the temporal lobe. High spine densities were associated with decreased brain weights and were most commonly found in ASD subjects with lower levels of cognitive functioning. Greater spine densities in ASD subjects provide structural support for recent suggestions of connectional changes within the cerebral cortex that may result in altered cortical computations." @default.
- W2137395087 created "2016-06-24" @default.
- W2137395087 creator A5018092975 @default.
- W2137395087 creator A5069849278 @default.
- W2137395087 date "2010-01-01" @default.
- W2137395087 modified "2023-10-09" @default.
- W2137395087 title "Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders" @default.
- W2137395087 cites W1490756748 @default.
- W2137395087 cites W1571543296 @default.
- W2137395087 cites W1579305661 @default.
- W2137395087 cites W1587787769 @default.
- W2137395087 cites W1587884197 @default.
- W2137395087 cites W1969590947 @default.
- W2137395087 cites W1975317900 @default.
- W2137395087 cites W1978611788 @default.
- W2137395087 cites W1980309199 @default.
- W2137395087 cites W1984854704 @default.
- W2137395087 cites W1985540036 @default.
- W2137395087 cites W1986603538 @default.
- W2137395087 cites W1996859891 @default.
- W2137395087 cites W2000619876 @default.
- W2137395087 cites W2002012536 @default.
- W2137395087 cites W2005817756 @default.
- W2137395087 cites W2009140566 @default.
- W2137395087 cites W2021243932 @default.
- W2137395087 cites W2025180319 @default.
- W2137395087 cites W2026125217 @default.
- W2137395087 cites W2029064689 @default.
- W2137395087 cites W2030271375 @default.
- W2137395087 cites W2034853194 @default.
- W2137395087 cites W2036190503 @default.
- W2137395087 cites W2037689983 @default.
- W2137395087 cites W2039031619 @default.
- W2137395087 cites W2041089391 @default.
- W2137395087 cites W2042999794 @default.
- W2137395087 cites W2043625808 @default.
- W2137395087 cites W2049255471 @default.
- W2137395087 cites W2050947021 @default.
- W2137395087 cites W2051900991 @default.
- W2137395087 cites W2057200806 @default.
- W2137395087 cites W2059721310 @default.
- W2137395087 cites W2060526931 @default.
- W2137395087 cites W2062807511 @default.
- W2137395087 cites W2064254171 @default.
- W2137395087 cites W2064364338 @default.
- W2137395087 cites W2070763857 @default.
- W2137395087 cites W2071482305 @default.
- W2137395087 cites W2073650605 @default.
- W2137395087 cites W2075164262 @default.
- W2137395087 cites W2076600981 @default.
- W2137395087 cites W2081713212 @default.
- W2137395087 cites W2082863207 @default.
- W2137395087 cites W2083907571 @default.
- W2137395087 cites W2084225443 @default.
- W2137395087 cites W2088931596 @default.
- W2137395087 cites W2091612053 @default.
- W2137395087 cites W2091955499 @default.
- W2137395087 cites W2092120221 @default.
- W2137395087 cites W2093991561 @default.
- W2137395087 cites W2096918711 @default.
- W2137395087 cites W2098391962 @default.
- W2137395087 cites W2100999082 @default.
- W2137395087 cites W2103456848 @default.
- W2137395087 cites W2105245235 @default.
- W2137395087 cites W2105549490 @default.
- W2137395087 cites W2106913811 @default.
- W2137395087 cites W2108322437 @default.
- W2137395087 cites W2109228085 @default.
- W2137395087 cites W2113136223 @default.
- W2137395087 cites W2118201036 @default.
- W2137395087 cites W2124161234 @default.
- W2137395087 cites W2126286563 @default.
- W2137395087 cites W2126819661 @default.
- W2137395087 cites W2128359078 @default.
- W2137395087 cites W2129712840 @default.
- W2137395087 cites W2131541104 @default.
- W2137395087 cites W2137673855 @default.
- W2137395087 cites W2139399313 @default.
- W2137395087 cites W2139528091 @default.
- W2137395087 cites W2141176410 @default.
- W2137395087 cites W2144696231 @default.
- W2137395087 cites W2146437136 @default.
- W2137395087 cites W2146511652 @default.
- W2137395087 cites W2148673800 @default.
- W2137395087 cites W2148788336 @default.
- W2137395087 cites W2159813274 @default.
- W2137395087 cites W2160335616 @default.
- W2137395087 cites W2161450501 @default.
- W2137395087 cites W2165137514 @default.
- W2137395087 cites W2165896210 @default.
- W2137395087 cites W2887232778 @default.
- W2137395087 cites W4236081599 @default.
- W2137395087 cites W4240325318 @default.
- W2137395087 cites W4246878015 @default.
- W2137395087 cites W4378698872 @default.
- W2137395087 doi "https://doi.org/10.1016/j.brainres.2009.09.120" @default.
- W2137395087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19896929" @default.
- W2137395087 hasPublicationYear "2010" @default.