Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137398417> ?p ?o ?g. }
- W2137398417 endingPage "224" @default.
- W2137398417 startingPage "207" @default.
- W2137398417 abstract "Human epidermal growth factor receptor type 2 (HER2)-positive breast carcinoma is highly aggressive and mostly metastatic in nature though curable/manageable in part by molecular targeted therapy. Recent evidence suggests a subtype of cells within HER2-positive breast tumors that concomitantly expresses the urokinase plasminogen activator receptor (uPAR) with inherent stem cell/mesenchymal-like properties promoting tumor cell motility and a metastatic phenotype. This HER-positive/uPAR-positive subtype may be partially responsible for the failure of HER2-targeted treatment strategies. Herein we discuss and substantiate the cumulative preclinical and clinical evidence on HER2-uPAR cooperativity in terms of gene co-amplification and/or mRNA/protein co-overexpression. We then propose a regulatory signaling model that we hypothesize to maintain upregulation and cooperativity between HER2 and uPAR in aggressive breast cancer. An improved understanding of the HER2/uPAR interaction in breast cancer will provide critical biomolecular information that may help better predict disease course and response to therapy." @default.
- W2137398417 created "2016-06-24" @default.
- W2137398417 creator A5019198316 @default.
- W2137398417 creator A5031592069 @default.
- W2137398417 creator A5060335037 @default.
- W2137398417 creator A5061261970 @default.
- W2137398417 creator A5085345182 @default.
- W2137398417 date "2015-03-23" @default.
- W2137398417 modified "2023-10-17" @default.
- W2137398417 title "HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer" @default.
- W2137398417 cites W125937443 @default.
- W2137398417 cites W1506680628 @default.
- W2137398417 cites W1520023565 @default.
- W2137398417 cites W1525911149 @default.
- W2137398417 cites W1546709038 @default.
- W2137398417 cites W1559797510 @default.
- W2137398417 cites W1599285204 @default.
- W2137398417 cites W1605937955 @default.
- W2137398417 cites W1606273823 @default.
- W2137398417 cites W161146112 @default.
- W2137398417 cites W1644299043 @default.
- W2137398417 cites W1763604934 @default.
- W2137398417 cites W1767727568 @default.
- W2137398417 cites W1837870834 @default.
- W2137398417 cites W1867197625 @default.
- W2137398417 cites W1930379456 @default.
- W2137398417 cites W1964953798 @default.
- W2137398417 cites W1967612488 @default.
- W2137398417 cites W1972158913 @default.
- W2137398417 cites W1973053090 @default.
- W2137398417 cites W1976052438 @default.
- W2137398417 cites W1976203623 @default.
- W2137398417 cites W1979524238 @default.
- W2137398417 cites W1982146272 @default.
- W2137398417 cites W1984795762 @default.
- W2137398417 cites W1993913242 @default.
- W2137398417 cites W1994829495 @default.
- W2137398417 cites W1995406904 @default.
- W2137398417 cites W1998496751 @default.
- W2137398417 cites W1998811052 @default.
- W2137398417 cites W1998985056 @default.
- W2137398417 cites W1999428813 @default.
- W2137398417 cites W2001627828 @default.
- W2137398417 cites W2002951101 @default.
- W2137398417 cites W2003008393 @default.
- W2137398417 cites W2004264100 @default.
- W2137398417 cites W2004280628 @default.
- W2137398417 cites W2007259429 @default.
- W2137398417 cites W2009218955 @default.
- W2137398417 cites W2012915718 @default.
- W2137398417 cites W2013899180 @default.
- W2137398417 cites W2015314629 @default.
- W2137398417 cites W2016119638 @default.
- W2137398417 cites W2020290519 @default.
- W2137398417 cites W2020671978 @default.
- W2137398417 cites W2021556751 @default.
- W2137398417 cites W2022818174 @default.
- W2137398417 cites W2023316892 @default.
- W2137398417 cites W2023826235 @default.
- W2137398417 cites W2025093834 @default.
- W2137398417 cites W2025152386 @default.
- W2137398417 cites W2029169609 @default.
- W2137398417 cites W2030040451 @default.
- W2137398417 cites W2030610316 @default.
- W2137398417 cites W2033961200 @default.
- W2137398417 cites W2035474904 @default.
- W2137398417 cites W2036900122 @default.
- W2137398417 cites W2038653804 @default.
- W2137398417 cites W2039469454 @default.
- W2137398417 cites W2040526629 @default.
- W2137398417 cites W2040531686 @default.
- W2137398417 cites W2040647048 @default.
- W2137398417 cites W2041805523 @default.
- W2137398417 cites W2043348423 @default.
- W2137398417 cites W2044702943 @default.
- W2137398417 cites W2046748396 @default.
- W2137398417 cites W2047861359 @default.
- W2137398417 cites W2050328564 @default.
- W2137398417 cites W2053744053 @default.
- W2137398417 cites W2056614490 @default.
- W2137398417 cites W2058613857 @default.
- W2137398417 cites W2059411043 @default.
- W2137398417 cites W2060401171 @default.
- W2137398417 cites W2063778637 @default.
- W2137398417 cites W2065608086 @default.
- W2137398417 cites W2065961736 @default.
- W2137398417 cites W2068872058 @default.
- W2137398417 cites W2070212400 @default.
- W2137398417 cites W2072778118 @default.
- W2137398417 cites W2073953651 @default.
- W2137398417 cites W2077238012 @default.
- W2137398417 cites W2077252019 @default.
- W2137398417 cites W2082187247 @default.
- W2137398417 cites W2082431893 @default.
- W2137398417 cites W2083527129 @default.
- W2137398417 cites W2085046739 @default.
- W2137398417 cites W2085488377 @default.
- W2137398417 cites W2085852797 @default.