FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137409810> ?p ?o ?g. }

• W2137409810 endingPage "G186" @default.
• W2137409810 startingPage "G177" @default.
• W2137409810 abstract "Necrotizing enterocolitis (NEC) is an inflammatory disease with evidence of increased production of proinflammatory cytokines in the intestinal mucosa. Lactobacillus reuteri DSM 17938 (LR17938) has been shown to have anti-inflammatory activities in an experimental model of NEC. Activated effector lymphocyte recruitment to sites of inflammation requires the sequential engagement of adhesion molecules such as CD44. The phenotype of CD44(+)CD45RB(lo) separates T effector/memory (Tem) cells from naive (CD44(-)CD45RB(hi)) cells. It is unknown whether these Tem cells participate in the inflammation associated with NEC and can be altered by LR17938. NEC was induced in 8- to 10-day-old C57BL/6J mice by gavage feeding with formula and exposure to hypoxia and cold stress for 4 days. Survival curves and histological scores were analyzed. Lymphocytes isolated from mesenteric lymph nodes and ileum were labeled for CD4, CD44, CD45RB, intracellular Foxp3, and Helios and subsequently analyzed by flow cytometry. LR17938 decreased mortality and the incidence and severity of NEC. The percentage of Tem cells in the ileum and mesenteric lymph nodes was increased in NEC but decreased by LR17938. Conversely, the percentage of CD4(+)Foxp3(+) regulatory T (Treg) cells in the intestine decreased during NEC and was restored to normal by LR17938. The majority of the Treg cells preserved by LR17938 were Helios+ subsets, possibly of thymic origin. In conclusion, LR17938 may represent a useful treatment to prevent NEC. The mechanism of protection by LR17938 involves modulation of the balance between Tem and Treg cells. These T cell subsets might be potential biomarkers and therapeutic targets during intestinal inflammation." @default.
• W2137409810 created "2016-06-24" @default.
• W2137409810 creator A5030355124 @default.
• W2137409810 creator A5042115463 @default.
• W2137409810 creator A5045383722 @default.
• W2137409810 creator A5081042133 @default.
• W2137409810 date "2014-07-15" @default.
• W2137409810 modified "2023-09-27" @default.
• W2137409810 title "<i>Lactobacillus reuteri</i> DSM 17938 differentially modulates effector memory T cells and Foxp3⁺ regulatory T cells in a mouse model of necrotizing enterocolitis" @default.
• W2137409810 cites W1908766372 @default.
• W2137409810 cites W1926970588 @default.
• W2137409810 cites W1947770621 @default.
• W2137409810 cites W1963808434 @default.
• W2137409810 cites W1967665214 @default.
• W2137409810 cites W1967765380 @default.
• W2137409810 cites W1968217734 @default.
• W2137409810 cites W1972451040 @default.
• W2137409810 cites W1981980129 @default.
• W2137409810 cites W1983209533 @default.
• W2137409810 cites W1987735044 @default.
• W2137409810 cites W1989825777 @default.
• W2137409810 cites W1992957230 @default.
• W2137409810 cites W2001835498 @default.
• W2137409810 cites W2012594125 @default.
• W2137409810 cites W2014956339 @default.
• W2137409810 cites W2015250987 @default.
• W2137409810 cites W2019265636 @default.
• W2137409810 cites W2020014038 @default.
• W2137409810 cites W2020976328 @default.
• W2137409810 cites W2035335588 @default.
• W2137409810 cites W2035339960 @default.
• W2137409810 cites W2037741362 @default.
• W2137409810 cites W2043551077 @default.
• W2137409810 cites W2043784391 @default.
• W2137409810 cites W2044271159 @default.
• W2137409810 cites W2047710679 @default.
• W2137409810 cites W2053891850 @default.
• W2137409810 cites W2056826548 @default.
• W2137409810 cites W2061391644 @default.
• W2137409810 cites W2076025706 @default.
• W2137409810 cites W2079576804 @default.
• W2137409810 cites W2084533786 @default.
• W2137409810 cites W2091622299 @default.
• W2137409810 cites W2094412198 @default.
• W2137409810 cites W2103890250 @default.
• W2137409810 cites W2106738018 @default.
• W2137409810 cites W2110934836 @default.
• W2137409810 cites W2111329034 @default.
• W2137409810 cites W2113349650 @default.
• W2137409810 cites W2114151609 @default.
• W2137409810 cites W2115528715 @default.
• W2137409810 cites W2123435121 @default.
• W2137409810 cites W2126283900 @default.
• W2137409810 cites W2126310398 @default.
• W2137409810 cites W2127331995 @default.
• W2137409810 cites W2130379438 @default.
• W2137409810 cites W2133462434 @default.
• W2137409810 cites W2135275990 @default.
• W2137409810 cites W2148134626 @default.
• W2137409810 cites W2148411835 @default.
• W2137409810 cites W2150636980 @default.
• W2137409810 cites W2151081117 @default.
• W2137409810 cites W2153949996 @default.
• W2137409810 cites W2157641302 @default.
• W2137409810 cites W2158571393 @default.
• W2137409810 cites W2160619254 @default.
• W2137409810 cites W2163194273 @default.
• W2137409810 cites W2169921310 @default.
• W2137409810 cites W4235469056 @default.
• W2137409810 cites W4236240401 @default.
• W2137409810 cites W4243225298 @default.
• W2137409810 doi "https://doi.org/10.1152/ajpgi.00038.2014" @default.
• W2137409810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4101683" @default.
• W2137409810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24852566" @default.
• W2137409810 hasPublicationYear "2014" @default.
• W2137409810 type Work @default.
• W2137409810 sameAs 2137409810 @default.
• W2137409810 citedByCount "66" @default.
• W2137409810 countsByYear W21374098102015 @default.
• W2137409810 countsByYear W21374098102016 @default.
• W2137409810 countsByYear W21374098102017 @default.
• W2137409810 countsByYear W21374098102018 @default.
• W2137409810 countsByYear W21374098102019 @default.
• W2137409810 countsByYear W21374098102020 @default.
• W2137409810 countsByYear W21374098102021 @default.
• W2137409810 countsByYear W21374098102022 @default.
• W2137409810 countsByYear W21374098102023 @default.
• W2137409810 crossrefType "journal-article" @default.
• W2137409810 hasAuthorship W2137409810A5030355124 @default.
• W2137409810 hasAuthorship W2137409810A5042115463 @default.
• W2137409810 hasAuthorship W2137409810A5045383722 @default.
• W2137409810 hasAuthorship W2137409810A5081042133 @default.
• W2137409810 hasBestOaLocation W21374098102 @default.
• W2137409810 hasConcept C126322002 @default.
• W2137409810 hasConcept C1491633281 @default.
• W2137409810 hasConcept C164027704 @default.
• W2137409810 hasConcept C203014093 @default.
• W2137409810 hasConcept C2775898472 @default.

• next