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• W2137452184 abstract "Stem cell biology started with the analysis of somatic stem cells that function to maintain the adult body. We now know that the body is maintained by regeneration of a wide range of cell types, such as skin cells, blood cells and gastrointestinal mucous cells, from somatic stem cells. This regenerative activity is essential for survival. Regenerative medicine was initiated to identify therapies that support and/or accelerate this natural regenerative ability. For example, bone marrow transplantation is a therapy for reconstituting hematopoiesis from the hematopoietic stem cells present in the donor bone marrow. The successful development of a protocol for obtaining human embryonic stem (ES) cells prompted medical scientists to utilize human ES cells for regenerative medicine. However, use of these cells raises ethical issues as they are derived from human embryos. An alternative approach using ES-like pluripotent stem cells has the considerable advantage that it does not necessitate use of human embryos. Pluripotent stem cells can be induced from terminally differentiated somatic cells by the introduction of only four defined factors. The products of this method are termed induced pluripotent stem (iPS) cells. iPS cells have considerable promise as a substitute for ES cells not only for regenerative medicine but also in many other fields. For example, liver and heart cells derived from iPS cells can be used in pharmaceutical research. In addition, iPS cell technology opens new avenues of disease research, for example, by construction of so-called disease-specific iPS cells from a patient's somatic cells." @default.
• W2137452184 created "2016-06-24" @default.
• W2137452184 creator A5058612697 @default.
• W2137452184 date "2010-04-05" @default.
• W2137452184 modified "2023-09-24" @default.
• W2137452184 title "Induced pluripotent stem (iPS) cells offer a powerful new tool for the life sciences" @default.
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• W2137452184 doi "https://doi.org/10.46582/jsrm.0601002" @default.
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