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- W2137475137 abstract "Summary Enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC) are closely related pathogens. Both use a type III secretion system (TTSS) encoded by the ‘locus of enterocyte effacement’ (LEE) to subvert and attach to epithelial cells through the injection of a repertoire of effector molecules. Here, we report the identification of a new TTSS translocated effector molecule called Cif, which blocks cell cycle G 2 /M transition and induces the formation of stress fibres through the recruitment of focal adhesions. Cif is not encoded by the LEE but by a lambdoid prophage present in EPEC and EHEC. A cif mutant causes localized effacement of microvilli and intimately attaches to the host cell surface, but is defective in the ability to block mitosis. When expressed in TTSS competent LEE‐positive pathogens, Cif is injected into the infected epithelial cells. These cells arrested at the G 2 /M phase displayed accumulation of inactive phosphorylated Cdk1. In conclusion, Cif is a new member of a growing family of bacterial cyclomodulins that subvert the host eukaryotic cell cycle." @default.
- W2137475137 created "2016-06-24" @default.
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- W2137475137 date "2003-11-11" @default.
- W2137475137 modified "2023-10-18" @default.
- W2137475137 title "Enteropathogenic and enterohaemorrhagic Escherichia coli deliver a novel effector called Cif, which blocks cell cycle G2/M transition" @default.
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- W2137475137 doi "https://doi.org/10.1046/j.1365-2958.2003.03821.x" @default.
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