Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137479670> ?p ?o ?g. }
- W2137479670 endingPage "22" @default.
- W2137479670 startingPage "9" @default.
- W2137479670 abstract "The various Wnt pathways that are related to upper limb anomalies are reviewed. Abnormalities in the Wnt7a pathway (located in the dorsal ectoderm) produce several clinically relevant conditions such as the palmar duplication syndrome, nail patella syndrome, ulnar ray deficiency, limb hypoplasia, polysyndactyly and the palmar nail syndrome. Abnormalities of the Wnt3/3a pathway (located in the apical ectodermal ridge) include tetra-amelia and loss of the distal phalanges/nails. Abnormalities of the Wnt5/5a pathway (located in the apical ectodermal ridge as well as in the mesoderm) will affect chondrogenesis of the developing limb and experimental Wnt5a −/− limbs have terminal adactyly. Chondrogenesis and limb muscle differentiation are both affected by several Wnt pathways and these will be reviewed in details. Abnormalities in LRP 5/6 (a co-receptor for Wnts) lead to congenital bone disease and Wnt4 is specifically involved in joint development. Finally, the relationship between the Wnt pathway and SALL4 (mutations of which cause Okihiro/Duane-radial ray deficiency in humans) are discussed." @default.
- W2137479670 created "2016-06-24" @default.
- W2137479670 creator A5028221527 @default.
- W2137479670 date "2010-08-13" @default.
- W2137479670 modified "2023-09-23" @default.
- W2137479670 title "WNT pathways and upper limb anomalies" @default.
- W2137479670 cites W1498696467 @default.
- W2137479670 cites W1539885560 @default.
- W2137479670 cites W1575984269 @default.
- W2137479670 cites W1591458484 @default.
- W2137479670 cites W1611720630 @default.
- W2137479670 cites W1651423553 @default.
- W2137479670 cites W1683271789 @default.
- W2137479670 cites W1939881246 @default.
- W2137479670 cites W1947391889 @default.
- W2137479670 cites W1964525580 @default.
- W2137479670 cites W1967046291 @default.
- W2137479670 cites W1967198448 @default.
- W2137479670 cites W1968416067 @default.
- W2137479670 cites W1969704449 @default.
- W2137479670 cites W1971943177 @default.
- W2137479670 cites W1973422437 @default.
- W2137479670 cites W1977447353 @default.
- W2137479670 cites W1978259142 @default.
- W2137479670 cites W1980778918 @default.
- W2137479670 cites W1982404120 @default.
- W2137479670 cites W1987588903 @default.
- W2137479670 cites W1994610109 @default.
- W2137479670 cites W2002391499 @default.
- W2137479670 cites W2002725330 @default.
- W2137479670 cites W2005713680 @default.
- W2137479670 cites W2010070885 @default.
- W2137479670 cites W2010217881 @default.
- W2137479670 cites W2010496313 @default.
- W2137479670 cites W2010909290 @default.
- W2137479670 cites W2010921681 @default.
- W2137479670 cites W2017531120 @default.
- W2137479670 cites W2018602900 @default.
- W2137479670 cites W2020352822 @default.
- W2137479670 cites W2021948683 @default.
- W2137479670 cites W2025682939 @default.
- W2137479670 cites W2026884255 @default.
- W2137479670 cites W2027416198 @default.
- W2137479670 cites W2030029457 @default.
- W2137479670 cites W2030509093 @default.
- W2137479670 cites W2031862844 @default.
- W2137479670 cites W2034176382 @default.
- W2137479670 cites W2034351801 @default.
- W2137479670 cites W2037834645 @default.
- W2137479670 cites W2039282080 @default.
- W2137479670 cites W2040012768 @default.
- W2137479670 cites W2041328951 @default.
- W2137479670 cites W2045216907 @default.
- W2137479670 cites W2045878670 @default.
- W2137479670 cites W2046781874 @default.
- W2137479670 cites W2052407549 @default.
- W2137479670 cites W2054212910 @default.
- W2137479670 cites W2055852018 @default.
- W2137479670 cites W2056752656 @default.
- W2137479670 cites W2059532513 @default.
- W2137479670 cites W2059614045 @default.
- W2137479670 cites W2061867575 @default.
- W2137479670 cites W2062436394 @default.
- W2137479670 cites W2066078074 @default.
- W2137479670 cites W2069229031 @default.
- W2137479670 cites W2073676252 @default.
- W2137479670 cites W2075639475 @default.
- W2137479670 cites W2080372560 @default.
- W2137479670 cites W2084090304 @default.
- W2137479670 cites W2087560312 @default.
- W2137479670 cites W2087606280 @default.
- W2137479670 cites W2091459202 @default.
- W2137479670 cites W2091709015 @default.
- W2137479670 cites W2098067206 @default.
- W2137479670 cites W2110838173 @default.
- W2137479670 cites W2114094342 @default.
- W2137479670 cites W2116610925 @default.
- W2137479670 cites W2125204092 @default.
- W2137479670 cites W2142039491 @default.
- W2137479670 cites W2147373137 @default.
- W2137479670 cites W2150134228 @default.
- W2137479670 cites W2151076343 @default.
- W2137479670 cites W2154041910 @default.
- W2137479670 cites W2158919523 @default.
- W2137479670 cites W2159263213 @default.
- W2137479670 cites W2164419770 @default.
- W2137479670 cites W2165868509 @default.
- W2137479670 cites W2166705426 @default.
- W2137479670 cites W2589421963 @default.
- W2137479670 cites W4236274382 @default.
- W2137479670 doi "https://doi.org/10.1177/1753193410380502" @default.
- W2137479670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20709709" @default.
- W2137479670 hasPublicationYear "2010" @default.
- W2137479670 type Work @default.
- W2137479670 sameAs 2137479670 @default.
- W2137479670 citedByCount "39" @default.
- W2137479670 countsByYear W21374796702012 @default.
- W2137479670 countsByYear W21374796702013 @default.