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• W2137497029 endingPage "2254" @default.
• W2137497029 startingPage "2246" @default.
• W2137497029 abstract "3-4-(2-Fluoro-α-methyl-[1,1′-biphenyl]-4-acetyloxy)-3-methoxyphenyl]-2-propenoic acid 4-nitrooxy butyl ester (NCX-2216), a nitric oxide (NO)-releasing derivative of the cyclooxygenase-1-preferring nonsteroidal anti-inflammatory drug (NSAID) flurbiprofen, dramatically reduced both β-amyloid (Aβ) loads and Congo red staining in doubly transgenic (Tg) amyloid precursor protein plus presenilin-1 mice when administered at 375 ppm in diet between 7 and 12 months of age. This reduction was associated with a dramatic increase in the number of microglia expressing major histocompatibility complex-II antigen, a marker for microglial activation. In contrast, ibuprofen at 375 ppm in diet caused modest reductions in Aβ load but not Congo red staining, suggesting that the effects of this nonselective NSAID were restricted primarily to nonfibrillar deposits. We detected no effects of the cyclooxygenase-2-selective NSAID celecoxib at 175 ppm on amyloid deposition. In short-term studies of 12-month-old Tg mice, we found that the microglia-activating properties of NCX-2216 (7.5 mg · kg −1 · d −1 , s.c.) were present after 2 weeks of treatment. Microglia were not activated by NCX-2216 in non-Tg mice lacking Aβ deposits, nor were microglia activated in Tg animals by flurbiprofen (5 mg · kg −1 · d −1 ) alone. These data are consistent with the argument that activated microglia can clear Aβ deposits. We conclude that the NO-generating component of NCX-2216 confers biological actions that go beyond those of typical NSAIDs. In conclusion, NCX-2216 is more efficacious than ibuprofen or celecoxib in clearing Aβ deposits from the brains of Tg mice, implying potential benefit in the treatment of Alzheimer's dementia." @default.
• W2137497029 created "2016-06-24" @default.
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• W2137497029 date "2002-03-15" @default.
• W2137497029 modified "2023-09-23" @default.
• W2137497029 title "Microglial Activation and β-Amyloid Deposit Reduction Caused by a Nitric Oxide-Releasing Nonsteroidal Anti-Inflammatory Drug in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mice" @default.
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• W2137497029 cites W109402025 @default.
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• W2137497029 cites W1586876258 @default.
• W2137497029 cites W1621971853 @default.
• W2137497029 cites W1657319651 @default.
• W2137497029 cites W167550983 @default.
• W2137497029 cites W1693283493 @default.
• W2137497029 cites W1729010372 @default.
• W2137497029 cites W1836411230 @default.
• W2137497029 cites W1909194257 @default.
• W2137497029 cites W1920580857 @default.
• W2137497029 cites W1966510897 @default.
• W2137497029 cites W1967332056 @default.
• W2137497029 cites W1967549235 @default.
• W2137497029 cites W1968014528 @default.
• W2137497029 cites W1970250419 @default.
• W2137497029 cites W1970629667 @default.
• W2137497029 cites W1980543900 @default.
• W2137497029 cites W1980940682 @default.
• W2137497029 cites W1981264235 @default.
• W2137497029 cites W1985662930 @default.
• W2137497029 cites W1986847205 @default.
• W2137497029 cites W1987686583 @default.
• W2137497029 cites W1993909442 @default.
• W2137497029 cites W1994360125 @default.
• W2137497029 cites W1996694656 @default.
• W2137497029 cites W1997256771 @default.
• W2137497029 cites W2001210466 @default.
• W2137497029 cites W2005586302 @default.
• W2137497029 cites W2005681172 @default.
• W2137497029 cites W2009882167 @default.
• W2137497029 cites W2010464023 @default.
• W2137497029 cites W2012983715 @default.
• W2137497029 cites W2026896596 @default.
• W2137497029 cites W2029555926 @default.
• W2137497029 cites W2035928774 @default.
• W2137497029 cites W2037380525 @default.
• W2137497029 cites W2040603499 @default.
• W2137497029 cites W2045720033 @default.
• W2137497029 cites W2046454316 @default.
• W2137497029 cites W2052944919 @default.
• W2137497029 cites W2057716397 @default.
• W2137497029 cites W2068315260 @default.
• W2137497029 cites W2068467321 @default.
• W2137497029 cites W2077464099 @default.
• W2137497029 cites W2080691471 @default.
• W2137497029 cites W2082429191 @default.
• W2137497029 cites W2082431283 @default.
• W2137497029 cites W2090811490 @default.
• W2137497029 cites W2091874081 @default.
• W2137497029 cites W2092411904 @default.
• W2137497029 cites W2093902222 @default.
• W2137497029 cites W2099834641 @default.
• W2137497029 cites W2108689038 @default.
• W2137497029 cites W2109759840 @default.
• W2137497029 cites W2111405228 @default.
• W2137497029 cites W2115296748 @default.
• W2137497029 cites W2116784956 @default.
• W2137497029 cites W2118645025 @default.
• W2137497029 cites W2130063365 @default.
• W2137497029 cites W2140131793 @default.
• W2137497029 cites W2140425743 @default.
• W2137497029 cites W2142437726 @default.
• W2137497029 cites W2148152028 @default.
• W2137497029 cites W2148371215 @default.
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• W2137497029 cites W2412747503 @default.
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• W2137497029 cites W4296391647 @default.
• W2137497029 cites W4300414726 @default.
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• W2137497029 doi "https://doi.org/10.1523/jneurosci.22-06-02246.2002" @default.
• W2137497029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6758281" @default.
• W2137497029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11896164" @default.
• W2137497029 hasPublicationYear "2002" @default.
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