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- W2137521046 abstract "Recently a new type of proteins modulating the pharmacological profile of the calcitonin receptor-like receptor (CRLR) were identified. The receptor-activity-modifying proteins (RAMPs) were shown to be essential for the expression of a functional CRLR and furthermore the RAMPs seemed to modify ligand selectivity of CRLR: coexpression of CRLR and RAMP1 resulted in a CGRP1 type of receptor while an adrenomedullin receptor resulted when CRLR and RAMP2 were coexpressed. In the present study significant molecular expression of CRLR concomitant with RAMP1, 2 and 3 were demonstrated in human meningeal, cerebral and temporal arteries by use of reverse transcriptase polymerase chain reactions (RT-PCR). These findings support previous studies demonstrating functional CGRP1 receptors in human cranial arteries. Furthermore the present study suggests the potential for functional adrenomedullin receptors in human cranial arteries." @default.
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- W2137521046 date "1998-12-01" @default.
- W2137521046 modified "2023-09-23" @default.
- W2137521046 title "Expression of calcitonin receptor-like receptor and receptor-activity-modifying proteins in human cranial arteries" @default.
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- W2137521046 doi "https://doi.org/10.1016/s0304-3940(98)00844-1" @default.
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