FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137545824> ?p ?o ?g. }

• W2137545824 endingPage "58" @default.
• W2137545824 startingPage "45" @default.
• W2137545824 abstract "In a healing wound, inflammatory cells undergo apoptosis immediately beneath the leading edge of migrating epithelium. A potential mediator of this apoptosis pattern is p53, a protein with antiproliferative effects. Another protein, bcl-2, is antagonistic to p53 and prevents apoptosis. The purpose of this study was to determine the expression and location of p53 and bcl-2 mRNA and protein in healing wounds of normal and genetically diabetic mice. At various time points, full-thickness skin wounds from nondiabetic and diabetic mice were evaluated for p53 and bcl-2 by immunohistochemistry and in situ hybridization. Apoptosis patterns were also determined using the TUNEL method. Messenger RNA for p53 and bcl-2 were quantitated by competitive reverse transcriptase-polymerase chain reaction. Protein and mRNA for p53 were expressed in the leading edge of migrating epithelium, with apoptosis patterns closely following those of p53 production. p53 mRNA levels decreased soon after wounding, but after a few days, levels increased to greater than baseline. bcl-2 was localized to the wound epithelium, but relative amounts tended to oppose levels of p53, i.e, when p53 increased, bcl-2 decreased and vice versa. Wounds in diabetic animals showed a delayed onset of p53 mRNA expression but had persistently greater levels for longer periods of time. bcl-2 mRNA expression was further delayed in diabetic mice and did not develop to levels as high as p53. Production of both proteins was delayed, consistent with the mRNA expression. Our data show that immediately after wounding, bcl-2 increases and p53 decreases to allow for the cellular proliferation that is required for tissue repair. Over time, bcl-2 levels decrease while p53 levels increase to shut down the inflammatory process and down-regulate the proliferative response. Diabetic animals appear to lose the indirect relationship between p53 and bcl-2. This loss may contribute to the altered apoptosis patterns observed in diabetic healing." @default.
• W2137545824 created "2016-06-24" @default.
• W2137545824 creator A5020523727 @default.
• W2137545824 creator A5088287746 @default.
• W2137545824 date "2008-10-09" @default.
• W2137545824 modified "2023-10-18" @default.
• W2137545824 title "Expression and localization of p53 and bcl-2 in healing wounds in diabetic and nondiabetic mice" @default.
• W2137545824 cites W1522731616 @default.
• W2137545824 cites W1971928705 @default.
• W2137545824 cites W1981346133 @default.
• W2137545824 cites W1997208169 @default.
• W2137545824 cites W1999275729 @default.
• W2137545824 cites W1999497925 @default.
• W2137545824 cites W2009603041 @default.
• W2137545824 cites W2033214263 @default.
• W2137545824 cites W2039795195 @default.
• W2137545824 cites W2055309697 @default.
• W2137545824 cites W2057387446 @default.
• W2137545824 cites W2058591356 @default.
• W2137545824 cites W2093009120 @default.
• W2137545824 cites W2095711408 @default.
• W2137545824 cites W2143818520 @default.
• W2137545824 cites W4233484287 @default.
• W2137545824 cites W4294216491 @default.
• W2137545824 doi "https://doi.org/10.1046/j.1524-475x.2000.00045.x" @default.
• W2137545824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10760214" @default.
• W2137545824 hasPublicationYear "2008" @default.
• W2137545824 type Work @default.
• W2137545824 sameAs 2137545824 @default.
• W2137545824 citedByCount "44" @default.
• W2137545824 countsByYear W21375458242012 @default.
• W2137545824 countsByYear W21375458242013 @default.
• W2137545824 countsByYear W21375458242014 @default.
• W2137545824 countsByYear W21375458242015 @default.
• W2137545824 countsByYear W21375458242016 @default.
• W2137545824 countsByYear W21375458242017 @default.
• W2137545824 countsByYear W21375458242018 @default.
• W2137545824 countsByYear W21375458242019 @default.
• W2137545824 countsByYear W21375458242020 @default.
• W2137545824 countsByYear W21375458242021 @default.
• W2137545824 countsByYear W21375458242022 @default.
• W2137545824 countsByYear W21375458242023 @default.
• W2137545824 crossrefType "journal-article" @default.
• W2137545824 hasAuthorship W2137545824A5020523727 @default.
• W2137545824 hasAuthorship W2137545824A5088287746 @default.
• W2137545824 hasConcept C104317684 @default.
• W2137545824 hasConcept C105580179 @default.
• W2137545824 hasConcept C134018914 @default.
• W2137545824 hasConcept C153911025 @default.
• W2137545824 hasConcept C156719811 @default.
• W2137545824 hasConcept C16685009 @default.
• W2137545824 hasConcept C190283241 @default.
• W2137545824 hasConcept C196795494 @default.
• W2137545824 hasConcept C203014093 @default.
• W2137545824 hasConcept C204232928 @default.
• W2137545824 hasConcept C2780269544 @default.
• W2137545824 hasConcept C49105822 @default.
• W2137545824 hasConcept C502942594 @default.
• W2137545824 hasConcept C529295009 @default.
• W2137545824 hasConcept C54355233 @default.
• W2137545824 hasConcept C55493867 @default.
• W2137545824 hasConcept C555293320 @default.
• W2137545824 hasConcept C71924100 @default.
• W2137545824 hasConcept C81439078 @default.
• W2137545824 hasConcept C86803240 @default.
• W2137545824 hasConcept C95444343 @default.
• W2137545824 hasConceptScore W2137545824C104317684 @default.
• W2137545824 hasConceptScore W2137545824C105580179 @default.
• W2137545824 hasConceptScore W2137545824C134018914 @default.
• W2137545824 hasConceptScore W2137545824C153911025 @default.
• W2137545824 hasConceptScore W2137545824C156719811 @default.
• W2137545824 hasConceptScore W2137545824C16685009 @default.
• W2137545824 hasConceptScore W2137545824C190283241 @default.
• W2137545824 hasConceptScore W2137545824C196795494 @default.
• W2137545824 hasConceptScore W2137545824C203014093 @default.
• W2137545824 hasConceptScore W2137545824C204232928 @default.
• W2137545824 hasConceptScore W2137545824C2780269544 @default.
• W2137545824 hasConceptScore W2137545824C49105822 @default.
• W2137545824 hasConceptScore W2137545824C502942594 @default.
• W2137545824 hasConceptScore W2137545824C529295009 @default.
• W2137545824 hasConceptScore W2137545824C54355233 @default.
• W2137545824 hasConceptScore W2137545824C55493867 @default.
• W2137545824 hasConceptScore W2137545824C555293320 @default.
• W2137545824 hasConceptScore W2137545824C71924100 @default.
• W2137545824 hasConceptScore W2137545824C81439078 @default.
• W2137545824 hasConceptScore W2137545824C86803240 @default.
• W2137545824 hasConceptScore W2137545824C95444343 @default.
• W2137545824 hasIssue "1" @default.
• W2137545824 hasLocation W21375458241 @default.
• W2137545824 hasLocation W21375458242 @default.
• W2137545824 hasOpenAccess W2137545824 @default.
• W2137545824 hasPrimaryLocation W21375458241 @default.
• W2137545824 hasRelatedWork W2064378008 @default.
• W2137545824 hasRelatedWork W2069915122 @default.
• W2137545824 hasRelatedWork W2140242228 @default.
• W2137545824 hasRelatedWork W2325450529 @default.
• W2137545824 hasRelatedWork W2335356391 @default.
• W2137545824 hasRelatedWork W2469555320 @default.

• next