FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137607162> ?p ?o ?g. }

• W2137607162 abstract "It is well known that the disease progression in cystic fibrosis (CF) patients may be diverse in subjects with identical mutation in CFTR gene. It is quite possible that such heterogeneity is associated with TNF-α and/or LT-α gene polymorphisms since their products play a key role in inflammation. The aim of the study was to investigate the possible roles of TNF gene polymorphisms in CF disease phenotype and progression.198 CF patients and 130 control subjects were genotyped for both TNF-α-308GA and LT-α + 252AG polymorphisms.The carriers of the TNF-α-308A allele more frequently had asthma as compared to patients homozygous for the TNF-α-308 G allele. In 9 of 108 (8.3%) of LTα + 252AA carriers, tuberculosis infection has been documented, whereas there was no case of tuberculosis among patients, either homozygous or heterozygous for LTα +252 G alleles (p = 0.01). We never observed virus hepatitis among LTα + 252GA carriers. The genotypes TNF-α-308GG - LT-α + 252AA and TNF-α-308GA - LT-α + 252AG were unfavorable with regard to liver disease development (both p < 0.05). It was also shown that neutrophil elastase activity was higher in sputum specimens from high TNF producers with genotypes TNF-α-308GA or LT-α + 252GG. In addition the carriers of such genotypes demonstrated a higher risk of osteoporosis development (p values were 0.011 and 0.017, respectively).The carriers of genotypes, which are associated with higher TNF-α production, demonstrated increased frequency of asthma, higher levels of neutrophil elastase, and decrease of bone density. On the contrary, the carriers of genotypes associated with low TNF-α production showed a higher frequency of tuberculosis infection." @default.
• W2137607162 created "2016-06-24" @default.
• W2137607162 creator A5006923223 @default.
• W2137607162 creator A5014308559 @default.
• W2137607162 creator A5039131110 @default.
• W2137607162 creator A5043772271 @default.
• W2137607162 creator A5044357067 @default.
• W2137607162 creator A5048969628 @default.
• W2137607162 creator A5055561988 @default.
• W2137607162 date "2013-01-23" @default.
• W2137607162 modified "2023-09-27" @default.
• W2137607162 title "TNF gene polymorphisms in cystic fibrosis patients: contribution to the disease progression" @default.
• W2137607162 cites W1975950299 @default.
• W2137607162 cites W1981892938 @default.
• W2137607162 cites W1993947411 @default.
• W2137607162 cites W1996220604 @default.
• W2137607162 cites W2001046375 @default.
• W2137607162 cites W2007070816 @default.
• W2137607162 cites W2009008398 @default.
• W2137607162 cites W2015274620 @default.
• W2137607162 cites W2032581945 @default.
• W2137607162 cites W2033119210 @default.
• W2137607162 cites W2043990114 @default.
• W2137607162 cites W2051227416 @default.
• W2137607162 cites W2051405357 @default.
• W2137607162 cites W2056170579 @default.
• W2137607162 cites W2061542205 @default.
• W2137607162 cites W2072036660 @default.
• W2137607162 cites W2072380594 @default.
• W2137607162 cites W2079180753 @default.
• W2137607162 cites W2080778833 @default.
• W2137607162 cites W2090606943 @default.
• W2137607162 cites W2097422495 @default.
• W2137607162 cites W2098237519 @default.
• W2137607162 cites W2100901996 @default.
• W2137607162 cites W2111476737 @default.
• W2137607162 cites W2122539743 @default.
• W2137607162 cites W2132615551 @default.
• W2137607162 cites W2140806663 @default.
• W2137607162 cites W2165812603 @default.
• W2137607162 cites W2169157594 @default.
• W2137607162 cites W2336449142 @default.
• W2137607162 cites W3094195909 @default.
• W2137607162 cites W63385815 @default.
• W2137607162 doi "https://doi.org/10.1186/1479-5876-11-19" @default.
• W2137607162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3565881" @default.
• W2137607162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23343370" @default.
• W2137607162 hasPublicationYear "2013" @default.
• W2137607162 type Work @default.
• W2137607162 sameAs 2137607162 @default.
• W2137607162 citedByCount "17" @default.
• W2137607162 countsByYear W21376071622013 @default.
• W2137607162 countsByYear W21376071622014 @default.
• W2137607162 countsByYear W21376071622015 @default.
• W2137607162 countsByYear W21376071622016 @default.
• W2137607162 countsByYear W21376071622017 @default.
• W2137607162 countsByYear W21376071622018 @default.
• W2137607162 countsByYear W21376071622019 @default.
• W2137607162 countsByYear W21376071622022 @default.
• W2137607162 countsByYear W21376071622023 @default.
• W2137607162 crossrefType "journal-article" @default.
• W2137607162 hasAuthorship W2137607162A5006923223 @default.
• W2137607162 hasAuthorship W2137607162A5014308559 @default.
• W2137607162 hasAuthorship W2137607162A5039131110 @default.
• W2137607162 hasAuthorship W2137607162A5043772271 @default.
• W2137607162 hasAuthorship W2137607162A5044357067 @default.
• W2137607162 hasAuthorship W2137607162A5048969628 @default.
• W2137607162 hasAuthorship W2137607162A5055561988 @default.
• W2137607162 hasBestOaLocation W21376071621 @default.
• W2137607162 hasConcept C104317684 @default.
• W2137607162 hasConcept C126322002 @default.
• W2137607162 hasConcept C135763542 @default.
• W2137607162 hasConcept C142724271 @default.
• W2137607162 hasConcept C17991360 @default.
• W2137607162 hasConcept C180754005 @default.
• W2137607162 hasConcept C203014093 @default.
• W2137607162 hasConcept C2776301714 @default.
• W2137607162 hasConcept C2776938444 @default.
• W2137607162 hasConcept C2777075537 @default.
• W2137607162 hasConcept C2779134260 @default.
• W2137607162 hasConcept C2781069245 @default.
• W2137607162 hasConcept C54355233 @default.
• W2137607162 hasConcept C71924100 @default.
• W2137607162 hasConcept C86803240 @default.
• W2137607162 hasConceptScore W2137607162C104317684 @default.
• W2137607162 hasConceptScore W2137607162C126322002 @default.
• W2137607162 hasConceptScore W2137607162C135763542 @default.
• W2137607162 hasConceptScore W2137607162C142724271 @default.
• W2137607162 hasConceptScore W2137607162C17991360 @default.
• W2137607162 hasConceptScore W2137607162C180754005 @default.
• W2137607162 hasConceptScore W2137607162C203014093 @default.
• W2137607162 hasConceptScore W2137607162C2776301714 @default.
• W2137607162 hasConceptScore W2137607162C2776938444 @default.
• W2137607162 hasConceptScore W2137607162C2777075537 @default.
• W2137607162 hasConceptScore W2137607162C2779134260 @default.
• W2137607162 hasConceptScore W2137607162C2781069245 @default.
• W2137607162 hasConceptScore W2137607162C54355233 @default.
• W2137607162 hasConceptScore W2137607162C71924100 @default.
• W2137607162 hasConceptScore W2137607162C86803240 @default.
• W2137607162 hasIssue "1" @default.

• next