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- W2137629833 abstract "The two major metabolites of(±)3,4-methylenedioxyamphetamine (MDA), alpha-methyldopamine (α-MeDA) and3-O-methyl-α-methyldopamine (3-O-Me-α-MeDA), were administered to rats intracerebroventricularly and into brain parenchyma. In addition, their precursors, (α-MeDOPA and3-O-Me-α-MeDOPA, respectively) were administered systemically, individually and in combination. None of these treatments produced a lasting depletion of brain serotonin (5-HT). These findings suggest that neither of MDA's major metabolites mediate its toxic effects on 5-HT neurons and that either a minor metabolite is responsible or that alternate mechanisms are involved." @default.
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- W2137629833 date "1991-04-01" @default.
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- W2137629833 title "Major metabolites of(±)3,4-methylenedioxyamphetamine (MDA) do not mediate its toxic effects on brain serotonin neurons" @default.
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- W2137629833 doi "https://doi.org/10.1016/0006-8993(91)91297-e" @default.
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