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- W2137640955 abstract "Stimulation of salivary secretion is associated with a rise of [Ca2+]i in acinar cells. We examined the osmotic and ionic consequences of activation of Ca2+-dependent K+ and Cl− channels, by simultaneous optical determinations of cell volume and [Ca2+]i, [Cl−]i or [Na+]i during muscarinic stimulation of single salivary acinar cells, using a differential interference contrast (DIC)-fluorescence microscope. Carbachol caused a rapid rise of [Ca2+]i, as well as a substantial cell shrinkage. Despite variability in the level and kinetics of the subsequent sustained phase of the [Ca2+]i response, cell volume was correlated with [Ca2+]i in all cases. Elevated [Ca2+]i was both necessary and sufficient to cause these changes in cell volume. The proposition that changes in cell volume reflected changes in cell solute content was confirmed by simultaneously measuring [Cl−]i and cell volume. Simultaneous determinations of cell volume and [Na+]i indicated that the initial cell shrinkage was due entirely to K+ and Cl− efflux. Subsequent to the initial shrinkage, [Na+]i rose to high levels, primarily due to activation of Na+/H+ exchange. Thus, modulation of ion transport activities under isosmotic conditions results in substantial changes in cell solute content and cell volume. Subsequent to the early Ca2+-induced changes in these parameters, other transporters become active, but it is unclear what signals their activation. Cell swelling by osmotic dilution of the bath resulted in compensatory cell shrinkage (RVD) which was sensitive to K+ and Cl− gradients. Nevertheless, a rise of [Ca2+]i was not necessary for RVD. Osmotic shrinkage and/or cell acidification were insufficient to activate Na+ influx. Our data suggest that the intracellular signalling pathways used by cells to activate ion transport under anisosmotic conditions may not be the same as those employed under isosmotic conditions. © 1994 Wiley-Liss, Inc." @default.
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- W2137640955 date "1994-02-01" @default.
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- W2137640955 title "Isosmotic modulation of cell volume and intracellular ion activities during stimulation of single exocrine cells" @default.
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- W2137640955 doi "https://doi.org/10.1002/jez.1402680206" @default.
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