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• W2137662308 abstract "The interactions between a beta-adrenoceptor agonist (isoprenaline) and insulin on rates of hexose transport, glucose phosphorylation, glycogen synthesis and glycogenolysis were investigated in the incubated stripped soleus-muscle preparation of the rat. In the presence of 1 microM-isoprenaline, insulin was less effective in stimulating glucose phosphorylation and glycogen synthesis. The stimulation of glycogenolysis by isoprenaline was only slightly decreased even at high (10000 microunits/ml) concentrations of insulin. Insulin-stimulated phosphorylation of 2-deoxyglucose was decreased by isoprenaline. It is suggested that this decrease in the rate of glucose phosphorylation is caused by the observed elevated concentration of glucose 6-phosphate, which inhibits hexokinase activity. This conclusion is supported by the fact that isoprenaline had no effect on the stimulation of 3-O-methylglucose transport by insulin." @default.
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• W2137662308 date "1986-01-15" @default.
• W2137662308 modified "2023-10-14" @default.
• W2137662308 title "Effects of the <i>β</i>-adrenoceptor agonist isoprenaline on insulin-sensitivity in soleus muscle of the rat" @default.
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• W2137662308 doi "https://doi.org/10.1042/bj2330377" @default.
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