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• W2137667033 abstract "Angiogenesis is involved in the enlargement of preexisting vessels that sprout and divide or the formation of capillaries through trans-endothelial cell bridges (1). The development of a complex, mature vascular system is a process that requires endothelial cell activation, proliferation, and migration as well as the fundamental support of mural cells. The accessory cells such as pericytes and vascular smooth muscle cells interact with endothelial cells to form the complex network of vessels. Blood vessels form an extensive network of arteries, veins, arterioles, venules, and capillaries that transport liquids, solutes, gases, macromolecules, and cells within the vertebrate body. The ­average adult body has almost 100,000 miles of blood vessels. Angiogenic signals ­promote endothelial cell proliferation, increased resistance to apoptosis, changes in proteolytic balance, cytoskeletal reorganization, migration, and differentiation and formation of a new vascular lumen. In the adult body, blood vessels acquire a quiescent, nonangiogenic state but retain considerable growth potential that is activated during wound healing as well as in certain pathological processes, such as ocular and inflammatory disorders and cancers. In fact, angiogenesis is also a part of the pathogenesis of several human diseases and plays a key role in tumor growth and metastasis. While it is desirable to block the growth of new blood vessels under these circumstances, the controlled stimulation of angiogenesis is beneficial in other conditions when the local blood supply is impaired. N-3 long-chain polyunsaturated fatty acids (LCPUFAs) inhibit tumor angiogenesis (2, 3). In contrast, docosohexaenoic acid, 22:6n-3 (DHA), an important member of the n-3 fatty acid family, increases the synthesis of vascular endothelial growth factor (VEGF) with a concomitant increase in tube formation (as a measure of angiogenesis) in first-trimester human placental cells (4). This pro-angiogenic effect of DHA on placenta cells makes it nutritionally more important during pregnancy. We aim to review herein the modulation of the angiogenesis process by DHA in different cell systems." @default.
• W2137667033 created "2016-06-24" @default.
• W2137667033 creator A5060350709 @default.
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• W2137667033 date "2012-11-07" @default.
• W2137667033 modified "2023-09-25" @default.
• W2137667033 title "Docosahexaenoic Acid and Angiogenesis: A Review" @default.
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• W2137667033 doi "https://doi.org/10.1007/978-1-62703-215-5_11" @default.
• W2137667033 hasPublicationYear "2012" @default.
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