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- W2137674906 abstract "Summary The DDK complex is a conserved kinase complex, consisting of a catalytic subunit, Hsk1 (Cdc7), and its regulatory subunit Dfp1 (Dbf4). This kinase is essential for DNA replication. In this work, we show that dfp1-r35, which truncates the Dfp1 C-terminus zinc finger, causes severe meiotic defects, including reduced spore viability, reduced formation of programmed double strand breaks, altered expression of meiotic genes, and disrupted chromosome segregation. There is a high frequency of dyad formation. Mutants are also defective in the phosphorylation and degradation of the meiotic cohesion, Rec8, resulting in a failure to proceed through the MII division. These defects are more pronounced in a haploid meiosis model than in a normal diploid meiosis. Thus, several critical meiotic functions are linked specifically to the C-terminus of Dfp1, which may target specific substrates for phosphorylation by Hsk1." @default.
- W2137674906 created "2016-06-24" @default.
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- W2137674906 creator A5016762566 @default.
- W2137674906 creator A5054693792 @default.
- W2137674906 date "2013-06-11" @default.
- W2137674906 modified "2023-09-27" @default.
- W2137674906 title "The C-terminus of <i>S. pombe</i> DDK subunit Dfp1 is required for meiosis-specific transcription and cohesin cleavage" @default.
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- W2137674906 doi "https://doi.org/10.1242/bio.20135173" @default.
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