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- W2137675124 abstract "Abstract Peptide and peptidomimetic molecule arrays are emerging powerful tools for parallel screening of binding in proteomics and pharmaceutical discovery research. Up to now the common method of preparing peptide arrays was based on spotting on glass using a library of presynthesized peptides. However, due to the large number of monomers (amino acids) it is not possible to have combinatorial libraries which include all combinations of natural and synthetic amino acids. We describe a very flexible on‐chip oligopeptide synthesis method which uses the well developed t‐Boc based solid state synthesis chemistry. A very high degree of flexibility is achieved by using light photo generated acids and maskless projection lithography for spatially directed deprotection. Use of microfluidic chips enables moderately high densities, short reaction times and off‐the‐shelf chemicals. Examples are given from synthesis of metal ion binding peptides and epitope binding assys." @default.
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- W2137675124 date "2003-10-27" @default.
- W2137675124 modified "2023-10-18" @default.
- W2137675124 title "Light directed massively parallel on‐chip synthesis of peptide arrays with t‐Boc chemistry" @default.
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- W2137675124 doi "https://doi.org/10.1002/pmic.200300597" @default.
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