Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137675299> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2137675299 endingPage "439" @default.
- W2137675299 startingPage "433" @default.
- W2137675299 abstract "Superiority claims for improved efficacy are the backbone of clinical development of new therapies. However, not every new therapy in development allows for such a claim. Some therapies per se do not try to improve efficacy further but concentrate on important aspects in safety or convenience. Such improvements can be equally important to patients, and development strategies should be available for such compounds. A three‐arm design with placebo, active control and experimental treatment may be viewed as the golden standard for such compounds; however, it may be difficult if not impossible to add a placebo arm in certain diseases. In such situations, non‐inferiority designs are the only development option left. This paper will highlight some of the key issues with such designs in practice and will report experience from two studies from different therapeutic areas intended for regulatory submission. Copyright © 2011 John Wiley & Sons, Ltd." @default.
- W2137675299 created "2016-06-24" @default.
- W2137675299 creator A5017527519 @default.
- W2137675299 creator A5040423968 @default.
- W2137675299 creator A5078246051 @default.
- W2137675299 date "2011-09-01" @default.
- W2137675299 modified "2023-09-25" @default.
- W2137675299 title "Issues in the assessment of non-inferiority: perspectives drawn from case studies" @default.
- W2137675299 cites W1982268114 @default.
- W2137675299 cites W2065785235 @default.
- W2137675299 cites W2085705101 @default.
- W2137675299 cites W2090025081 @default.
- W2137675299 cites W2121368761 @default.
- W2137675299 cites W2145774014 @default.
- W2137675299 cites W3189355562 @default.
- W2137675299 doi "https://doi.org/10.1002/pst.512" @default.
- W2137675299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21932300" @default.
- W2137675299 hasPublicationYear "2011" @default.
- W2137675299 type Work @default.
- W2137675299 sameAs 2137675299 @default.
- W2137675299 citedByCount "14" @default.
- W2137675299 countsByYear W21376752992012 @default.
- W2137675299 countsByYear W21376752992013 @default.
- W2137675299 countsByYear W21376752992014 @default.
- W2137675299 countsByYear W21376752992015 @default.
- W2137675299 countsByYear W21376752992016 @default.
- W2137675299 countsByYear W21376752992017 @default.
- W2137675299 countsByYear W21376752992018 @default.
- W2137675299 countsByYear W21376752992020 @default.
- W2137675299 countsByYear W21376752992022 @default.
- W2137675299 crossrefType "journal-article" @default.
- W2137675299 hasAuthorship W2137675299A5017527519 @default.
- W2137675299 hasAuthorship W2137675299A5040423968 @default.
- W2137675299 hasAuthorship W2137675299A5078246051 @default.
- W2137675299 hasConcept C112930515 @default.
- W2137675299 hasConcept C127413603 @default.
- W2137675299 hasConcept C142724271 @default.
- W2137675299 hasConcept C15744967 @default.
- W2137675299 hasConcept C177713679 @default.
- W2137675299 hasConcept C19527891 @default.
- W2137675299 hasConcept C204787440 @default.
- W2137675299 hasConcept C27081682 @default.
- W2137675299 hasConcept C41008148 @default.
- W2137675299 hasConcept C539667460 @default.
- W2137675299 hasConcept C55587333 @default.
- W2137675299 hasConcept C71924100 @default.
- W2137675299 hasConceptScore W2137675299C112930515 @default.
- W2137675299 hasConceptScore W2137675299C127413603 @default.
- W2137675299 hasConceptScore W2137675299C142724271 @default.
- W2137675299 hasConceptScore W2137675299C15744967 @default.
- W2137675299 hasConceptScore W2137675299C177713679 @default.
- W2137675299 hasConceptScore W2137675299C19527891 @default.
- W2137675299 hasConceptScore W2137675299C204787440 @default.
- W2137675299 hasConceptScore W2137675299C27081682 @default.
- W2137675299 hasConceptScore W2137675299C41008148 @default.
- W2137675299 hasConceptScore W2137675299C539667460 @default.
- W2137675299 hasConceptScore W2137675299C55587333 @default.
- W2137675299 hasConceptScore W2137675299C71924100 @default.
- W2137675299 hasIssue "5" @default.
- W2137675299 hasLocation W21376752991 @default.
- W2137675299 hasLocation W21376752992 @default.
- W2137675299 hasOpenAccess W2137675299 @default.
- W2137675299 hasPrimaryLocation W21376752991 @default.
- W2137675299 hasRelatedWork W1989343317 @default.
- W2137675299 hasRelatedWork W1992433415 @default.
- W2137675299 hasRelatedWork W2043902988 @default.
- W2137675299 hasRelatedWork W2399580121 @default.
- W2137675299 hasRelatedWork W2748952813 @default.
- W2137675299 hasRelatedWork W2801016049 @default.
- W2137675299 hasRelatedWork W2899084033 @default.
- W2137675299 hasRelatedWork W3006244985 @default.
- W2137675299 hasRelatedWork W4233016836 @default.
- W2137675299 hasRelatedWork W52593140 @default.
- W2137675299 hasVolume "10" @default.
- W2137675299 isParatext "false" @default.
- W2137675299 isRetracted "false" @default.
- W2137675299 magId "2137675299" @default.
- W2137675299 workType "article" @default.