FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137680790> ?p ?o ?g. }

• W2137680790 endingPage "e1012" @default.
• W2137680790 startingPage "e1008" @default.
• W2137680790 abstract "ObjectivesTo evaluate the evolution of antibody avidity and Western blot reactivity in recently infected HIV-1 subjects and to study the impact of highly active antiretroviral therapy (HAART) on avidity maturation of HIV-1-specific immunoglobulin G (IgG) in patients with recent HIV-1 infection.MethodsThirty-six HIV-1 seroconverters were enrolled in this study and followed longitudinally over 24 months to evaluate if the administration of antiretroviral therapy during primary infection affects Western blot reactivity and the evolution of antibody avidity. The patients were divided into two groups; group A consisted of 19 HIV-1-untreated patients who did not receive any drug treatment during our follow-up period; group B consisted of 17 subjects who were treated early with an association of two nucleoside reverse transcriptase inhibitors (NRTI) and one non-nucleoside reverse transcriptase inhibitor (NNRTI) within 3 months after seroconversion.ResultsAt diagnosis, Western blot analysis and avidity index (mean value) were exactly matched in untreated and treated patients; subsequently, however, a significantly lower reactivity to HIV-1 pol and gag proteins and a lower avidity index (mean values) were observed in HAART-treated patients up until the end of the follow-up period.ConclusionsThe impaired production and maturation of the humoral immunological response in antiretroviral-treated patients might be related to a rapid suppression of HIV replication, driven by HAART. These results could have important implications in understanding the complex mechanism of the immune response during HIV infection. To evaluate the evolution of antibody avidity and Western blot reactivity in recently infected HIV-1 subjects and to study the impact of highly active antiretroviral therapy (HAART) on avidity maturation of HIV-1-specific immunoglobulin G (IgG) in patients with recent HIV-1 infection. Thirty-six HIV-1 seroconverters were enrolled in this study and followed longitudinally over 24 months to evaluate if the administration of antiretroviral therapy during primary infection affects Western blot reactivity and the evolution of antibody avidity. The patients were divided into two groups; group A consisted of 19 HIV-1-untreated patients who did not receive any drug treatment during our follow-up period; group B consisted of 17 subjects who were treated early with an association of two nucleoside reverse transcriptase inhibitors (NRTI) and one non-nucleoside reverse transcriptase inhibitor (NNRTI) within 3 months after seroconversion. At diagnosis, Western blot analysis and avidity index (mean value) were exactly matched in untreated and treated patients; subsequently, however, a significantly lower reactivity to HIV-1 pol and gag proteins and a lower avidity index (mean values) were observed in HAART-treated patients up until the end of the follow-up period. The impaired production and maturation of the humoral immunological response in antiretroviral-treated patients might be related to a rapid suppression of HIV replication, driven by HAART. These results could have important implications in understanding the complex mechanism of the immune response during HIV infection." @default.
• W2137680790 created "2016-06-24" @default.
• W2137680790 creator A5002888060 @default.
• W2137680790 creator A5035772301 @default.
• W2137680790 creator A5039414607 @default.
• W2137680790 creator A5049042544 @default.
• W2137680790 creator A5064646111 @default.
• W2137680790 creator A5078892728 @default.
• W2137680790 creator A5079709625 @default.
• W2137680790 date "2010-11-01" @default.
• W2137680790 modified "2023-10-18" @default.
• W2137680790 title "Incomplete IgG response to HIV-1 proteins and low avidity levels in recently converted HIV patients treated with early antiretroviral therapy" @default.
• W2137680790 cites W159878949 @default.
• W2137680790 cites W1969980303 @default.
• W2137680790 cites W1986552871 @default.
• W2137680790 cites W2011773861 @default.
• W2137680790 cites W2023319325 @default.
• W2137680790 cites W2043123409 @default.
• W2137680790 cites W2045871034 @default.
• W2137680790 cites W2046711152 @default.
• W2137680790 cites W2056118578 @default.
• W2137680790 cites W2067919331 @default.
• W2137680790 cites W2089700913 @default.
• W2137680790 cites W2091661448 @default.
• W2137680790 cites W2103425804 @default.
• W2137680790 cites W2106836525 @default.
• W2137680790 cites W2108662025 @default.
• W2137680790 cites W2108924430 @default.
• W2137680790 cites W2113983720 @default.
• W2137680790 cites W2129985262 @default.
• W2137680790 cites W2133540759 @default.
• W2137680790 cites W2137220504 @default.
• W2137680790 cites W2137338119 @default.
• W2137680790 cites W2148047918 @default.
• W2137680790 cites W2163133360 @default.
• W2137680790 cites W2320392364 @default.
• W2137680790 cites W2322028936 @default.
• W2137680790 doi "https://doi.org/10.1016/j.ijid.2010.06.015" @default.
• W2137680790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20869896" @default.
• W2137680790 hasPublicationYear "2010" @default.
• W2137680790 type Work @default.
• W2137680790 sameAs 2137680790 @default.
• W2137680790 citedByCount "15" @default.
• W2137680790 countsByYear W21376807902013 @default.
• W2137680790 countsByYear W21376807902014 @default.
• W2137680790 countsByYear W21376807902015 @default.
• W2137680790 countsByYear W21376807902016 @default.
• W2137680790 countsByYear W21376807902019 @default.
• W2137680790 countsByYear W21376807902021 @default.
• W2137680790 countsByYear W21376807902022 @default.
• W2137680790 countsByYear W21376807902023 @default.
• W2137680790 crossrefType "journal-article" @default.
• W2137680790 hasAuthorship W2137680790A5002888060 @default.
• W2137680790 hasAuthorship W2137680790A5035772301 @default.
• W2137680790 hasAuthorship W2137680790A5039414607 @default.
• W2137680790 hasAuthorship W2137680790A5049042544 @default.
• W2137680790 hasAuthorship W2137680790A5064646111 @default.
• W2137680790 hasAuthorship W2137680790A5078892728 @default.
• W2137680790 hasAuthorship W2137680790A5079709625 @default.
• W2137680790 hasBestOaLocation W21376807901 @default.
• W2137680790 hasConcept C104317684 @default.
• W2137680790 hasConcept C159047783 @default.
• W2137680790 hasConcept C159654299 @default.
• W2137680790 hasConcept C179223381 @default.
• W2137680790 hasConcept C203014093 @default.
• W2137680790 hasConcept C2776415932 @default.
• W2137680790 hasConcept C2776452011 @default.
• W2137680790 hasConcept C2777351918 @default.
• W2137680790 hasConcept C2777451964 @default.
• W2137680790 hasConcept C2780727368 @default.
• W2137680790 hasConcept C3013748606 @default.
• W2137680790 hasConcept C55493867 @default.
• W2137680790 hasConcept C71924100 @default.
• W2137680790 hasConcept C86803240 @default.
• W2137680790 hasConceptScore W2137680790C104317684 @default.
• W2137680790 hasConceptScore W2137680790C159047783 @default.
• W2137680790 hasConceptScore W2137680790C159654299 @default.
• W2137680790 hasConceptScore W2137680790C179223381 @default.
• W2137680790 hasConceptScore W2137680790C203014093 @default.
• W2137680790 hasConceptScore W2137680790C2776415932 @default.
• W2137680790 hasConceptScore W2137680790C2776452011 @default.
• W2137680790 hasConceptScore W2137680790C2777351918 @default.
• W2137680790 hasConceptScore W2137680790C2777451964 @default.
• W2137680790 hasConceptScore W2137680790C2780727368 @default.
• W2137680790 hasConceptScore W2137680790C3013748606 @default.
• W2137680790 hasConceptScore W2137680790C55493867 @default.
• W2137680790 hasConceptScore W2137680790C71924100 @default.
• W2137680790 hasConceptScore W2137680790C86803240 @default.
• W2137680790 hasIssue "11" @default.
• W2137680790 hasLocation W21376807901 @default.
• W2137680790 hasLocation W21376807902 @default.
• W2137680790 hasLocation W21376807903 @default.
• W2137680790 hasOpenAccess W2137680790 @default.
• W2137680790 hasPrimaryLocation W21376807901 @default.
• W2137680790 hasRelatedWork W1584315055 @default.
• W2137680790 hasRelatedWork W1976753572 @default.
• W2137680790 hasRelatedWork W1993882803 @default.
• W2137680790 hasRelatedWork W2031896543 @default.

• next