FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137693354> ?p ?o ?g. }

• W2137693354 endingPage "721" @default.
• W2137693354 startingPage "713" @default.
• W2137693354 abstract "Abstract TRAF1 and LSP1 are direct binding partners, and cooperate to promote survival of primary T cells in response to 4-1BB co-stimulation. 4-1BB is a member of the TNFR superfamily, which contributes to the activation of signaling pathways required for the survival of activated and memory T cells. We have shown previously that TRAF1, an adaptor protein recruited to 4-1BB, is required for 4-1BB-mediated CD8 T cell survival in vivo. With the use of a proteomics approach in primary T cells, we have identified LSP1 as a novel protein recruited to the 4-1BB signaling complex in a TRAF1-dependent manner. Further characterization of the interaction between TRAF1 and LSP1 revealed that LSP1 requires the TRAF-N domain of TRAF1 for direct association. Similarly to TRAF1−/− T cells, LSP1−/− T cells exhibit impaired ERK activation following stimulation through 4-1BB and consequently, are unable to down-modulate expression of the proapoptotic Bcl-2 family member Bim. Moreover, we demonstrate that the absence of LSP1 expression leads to defective expansion and survival of T cells in response to 4-1BB stimulation. Thus, we have identified LSP1 as a new mediator involved in 4-1BB signaling and T cell survival. Collectively, our work shows that TRAF1 and LSP1 cooperate downstream of 4-1BB to activate ERK signaling and down-modulate the levels of Bim leading to enhanced T cell survival." @default.
• W2137693354 created "2016-06-24" @default.
• W2137693354 creator A5001460168 @default.
• W2137693354 creator A5006431212 @default.
• W2137693354 creator A5015302551 @default.
• W2137693354 creator A5015635080 @default.
• W2137693354 creator A5020294373 @default.
• W2137693354 creator A5046685448 @default.
• W2137693354 creator A5074435400 @default.
• W2137693354 creator A5076377565 @default.
• W2137693354 creator A5077093856 @default.
• W2137693354 date "2013-05-01" @default.
• W2137693354 modified "2023-10-18" @default.
• W2137693354 title "Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells" @default.
• W2137693354 cites W1479918734 @default.
• W2137693354 cites W1492642877 @default.
• W2137693354 cites W1540593704 @default.
• W2137693354 cites W1545918761 @default.
• W2137693354 cites W1572596428 @default.
• W2137693354 cites W1605178114 @default.
• W2137693354 cites W1918154757 @default.
• W2137693354 cites W1932769252 @default.
• W2137693354 cites W1959677146 @default.
• W2137693354 cites W1973680986 @default.
• W2137693354 cites W1973909579 @default.
• W2137693354 cites W1979595147 @default.
• W2137693354 cites W1982983257 @default.
• W2137693354 cites W1988280075 @default.
• W2137693354 cites W2002154440 @default.
• W2137693354 cites W2007827117 @default.
• W2137693354 cites W2012766110 @default.
• W2137693354 cites W2026387078 @default.
• W2137693354 cites W2035389470 @default.
• W2137693354 cites W2042872424 @default.
• W2137693354 cites W2054888093 @default.
• W2137693354 cites W2058732867 @default.
• W2137693354 cites W2060138888 @default.
• W2137693354 cites W2061300591 @default.
• W2137693354 cites W2064558057 @default.
• W2137693354 cites W2067045583 @default.
• W2137693354 cites W2069836978 @default.
• W2137693354 cites W2085811557 @default.
• W2137693354 cites W2086095524 @default.
• W2137693354 cites W2095013915 @default.
• W2137693354 cites W2105267618 @default.
• W2137693354 cites W2106172212 @default.
• W2137693354 cites W2111583062 @default.
• W2137693354 cites W2116667195 @default.
• W2137693354 cites W2119220519 @default.
• W2137693354 cites W2121211022 @default.
• W2137693354 cites W2121613672 @default.
• W2137693354 cites W2121796473 @default.
• W2137693354 cites W2139249889 @default.
• W2137693354 cites W2147541997 @default.
• W2137693354 cites W2155517651 @default.
• W2137693354 cites W2156588547 @default.
• W2137693354 cites W2168957799 @default.
• W2137693354 cites W2280143417 @default.
• W2137693354 cites W4245729482 @default.
• W2137693354 doi "https://doi.org/10.1189/jlb.1112579" @default.
• W2137693354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23446150" @default.
• W2137693354 hasPublicationYear "2013" @default.
• W2137693354 type Work @default.
• W2137693354 sameAs 2137693354 @default.
• W2137693354 citedByCount "32" @default.
• W2137693354 countsByYear W21376933542013 @default.
• W2137693354 countsByYear W21376933542014 @default.
• W2137693354 countsByYear W21376933542015 @default.
• W2137693354 countsByYear W21376933542016 @default.
• W2137693354 countsByYear W21376933542017 @default.
• W2137693354 countsByYear W21376933542018 @default.
• W2137693354 countsByYear W21376933542019 @default.
• W2137693354 countsByYear W21376933542020 @default.
• W2137693354 countsByYear W21376933542022 @default.
• W2137693354 countsByYear W21376933542023 @default.
• W2137693354 crossrefType "journal-article" @default.
• W2137693354 hasAuthorship W2137693354A5001460168 @default.
• W2137693354 hasAuthorship W2137693354A5006431212 @default.
• W2137693354 hasAuthorship W2137693354A5015302551 @default.
• W2137693354 hasAuthorship W2137693354A5015635080 @default.
• W2137693354 hasAuthorship W2137693354A5020294373 @default.
• W2137693354 hasAuthorship W2137693354A5046685448 @default.
• W2137693354 hasAuthorship W2137693354A5074435400 @default.
• W2137693354 hasAuthorship W2137693354A5076377565 @default.
• W2137693354 hasAuthorship W2137693354A5077093856 @default.
• W2137693354 hasBestOaLocation W21376933541 @default.
• W2137693354 hasConcept C154317977 @default.
• W2137693354 hasConcept C167672396 @default.
• W2137693354 hasConcept C17991360 @default.
• W2137693354 hasConcept C183786373 @default.
• W2137693354 hasConcept C202751555 @default.
• W2137693354 hasConcept C203014093 @default.
• W2137693354 hasConcept C2776090121 @default.
• W2137693354 hasConcept C502942594 @default.
• W2137693354 hasConcept C54355233 @default.
• W2137693354 hasConcept C57074206 @default.
• W2137693354 hasConcept C62478195 @default.
• W2137693354 hasConcept C86803240 @default.

• next