Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137722306> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2137722306 endingPage "211" @default.
- W2137722306 startingPage "203" @default.
- W2137722306 abstract "This study was carried out to study the prophylactic effects of inhalation of nitric oxide (NO) before and during the induction of endotoxic shock.Eighteen anaesthetized pigs received an infusion of 10-20 microg kg(-1) endotoxin during 2 h after pre-treatment with the cortisol-synthesis inhibitor metyrapone. Three groups were tested (n = 6 each) and received 0, 0.2 or 20 ppm inhaled NO from 30 min before start of endotoxin infusion until 4 h after start of endotoxin. Both 0.2 and 20 ppm NO were able to improve blood gas values.Area above curve values of arterial P2/FiO2 from 0 to 4 h were 0.83 +/- 0.09 kPa h (control), 0.78 +/- 0.22 (0.2 ppm NO, non-significant) and 0.31 +/- 0.06 (20 ppm NO, P < 0.01, Mann-Whitney U-test, compared to control). Area under curve values of PCO2 from 0 to 4 h were 3.96 +/- 0.66 kPa h (control), 1.20 +/- 0.46 (0.2 ppm NO, P < 0.05, Mann-Whitney U-test, compared to control) and 2.78 +/- 1.06 (20 ppm NO group, non-significant). The increase in pulmonary arterial pressure (PAP) was partly prevented by 20 ppm NO, but not by 0.2 ppm NO at 4 h. Inhaled NO did not affect the levels of BAL fluid total protein, tumour necrosis factor-alpha, interleukin-8 and neutrophil counts.The addition of a high (20 ppm), but not a low (0.2 ppm), concentration of NO to the inhaled air during endotoxin shock improves arterial oxygen tension and reduces pulmonary artery pressure. Neither dose affects lung mechanics or inflammatory indices, in spite of being given prophylactically." @default.
- W2137722306 created "2016-06-24" @default.
- W2137722306 creator A5024074531 @default.
- W2137722306 creator A5057617279 @default.
- W2137722306 date "2003-09-19" @default.
- W2137722306 modified "2023-10-14" @default.
- W2137722306 title "Endotoxin-induced shock in the pig - limited effects of low and high concentrations of inhaled nitric oxide" @default.
- W2137722306 cites W1927797304 @default.
- W2137722306 cites W1988088021 @default.
- W2137722306 cites W1991691067 @default.
- W2137722306 cites W2000781818 @default.
- W2137722306 cites W2002762496 @default.
- W2137722306 cites W2006535161 @default.
- W2137722306 cites W2007302244 @default.
- W2137722306 cites W2018056489 @default.
- W2137722306 cites W2021353323 @default.
- W2137722306 cites W2025128201 @default.
- W2137722306 cites W2035438919 @default.
- W2137722306 cites W2043720899 @default.
- W2137722306 cites W2048504895 @default.
- W2137722306 cites W2049477937 @default.
- W2137722306 cites W2069796753 @default.
- W2137722306 cites W2079131490 @default.
- W2137722306 cites W2093216413 @default.
- W2137722306 cites W2098198071 @default.
- W2137722306 cites W2116064835 @default.
- W2137722306 cites W2123683702 @default.
- W2137722306 cites W2150078363 @default.
- W2137722306 cites W2155302225 @default.
- W2137722306 cites W4294658238 @default.
- W2137722306 doi "https://doi.org/10.1046/j.1365-201x.2003.01141.x" @default.
- W2137722306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14510784" @default.
- W2137722306 hasPublicationYear "2003" @default.
- W2137722306 type Work @default.
- W2137722306 sameAs 2137722306 @default.
- W2137722306 citedByCount "4" @default.
- W2137722306 countsByYear W21377223062021 @default.
- W2137722306 crossrefType "journal-article" @default.
- W2137722306 hasAuthorship W2137722306A5024074531 @default.
- W2137722306 hasAuthorship W2137722306A5057617279 @default.
- W2137722306 hasConcept C126322002 @default.
- W2137722306 hasConcept C134018914 @default.
- W2137722306 hasConcept C185592680 @default.
- W2137722306 hasConcept C2776954882 @default.
- W2137722306 hasConcept C2781300812 @default.
- W2137722306 hasConcept C42219234 @default.
- W2137722306 hasConcept C519581460 @default.
- W2137722306 hasConcept C71924100 @default.
- W2137722306 hasConceptScore W2137722306C126322002 @default.
- W2137722306 hasConceptScore W2137722306C134018914 @default.
- W2137722306 hasConceptScore W2137722306C185592680 @default.
- W2137722306 hasConceptScore W2137722306C2776954882 @default.
- W2137722306 hasConceptScore W2137722306C2781300812 @default.
- W2137722306 hasConceptScore W2137722306C42219234 @default.
- W2137722306 hasConceptScore W2137722306C519581460 @default.
- W2137722306 hasConceptScore W2137722306C71924100 @default.
- W2137722306 hasIssue "2" @default.
- W2137722306 hasLocation W21377223061 @default.
- W2137722306 hasLocation W21377223062 @default.
- W2137722306 hasOpenAccess W2137722306 @default.
- W2137722306 hasPrimaryLocation W21377223061 @default.
- W2137722306 hasRelatedWork W2006834589 @default.
- W2137722306 hasRelatedWork W2038106901 @default.
- W2137722306 hasRelatedWork W2074100616 @default.
- W2137722306 hasRelatedWork W2400723190 @default.
- W2137722306 hasRelatedWork W2415428995 @default.
- W2137722306 hasRelatedWork W2502977070 @default.
- W2137722306 hasRelatedWork W2748952813 @default.
- W2137722306 hasRelatedWork W3023818513 @default.
- W2137722306 hasRelatedWork W302992813 @default.
- W2137722306 hasRelatedWork W590771688 @default.
- W2137722306 hasVolume "179" @default.
- W2137722306 isParatext "false" @default.
- W2137722306 isRetracted "false" @default.
- W2137722306 magId "2137722306" @default.
- W2137722306 workType "article" @default.