FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137722420> ?p ?o ?g. }

• W2137722420 endingPage "78" @default.
• W2137722420 startingPage "268" @default.
• W2137722420 abstract "Cytochrome P-4503A, CYP2B, and P-450 reductase are induced by glucocorticoids, antiglucocorticoids such as pregnenolone 16alpha-carbonitrile, and drugs such as rifampin and phenobarbital. Although the pregnane X receptor is reported to mediate steroid and drug activation of CYP3A via a conserved cis-element in CYP3A genes, discrepancies exist between the induction of the endogenous CYP3A genes and the activation of the pregnane X receptor. It is a formal possibility that the glucocorticoid receptor may account for some of these discrepancies. To determine the requirement in vivo of the glucocorticoid receptor in expression of CYP3A and CYP2B, we compared the induction of these proteins in the livers of normal mice and mice with a targeted mutation in the glucocorticoid receptor. Mice lacking the glucocorticoid receptor show no difference in constitutive hepatic expression of CYP3A but show a decrease in the level of CYP2B. Glucocorticoid receptor-deficient mice challenged with either dexamethasone or pregnenolone 16alpha-carbonitrile failed to induce CYP2B proteins, whereas CYP2B was readily induced in (+/+) mice. In contrast, CYP3A and P-450 reductase proteins were induced by either inducer in wild-type and glucocorticoid receptor-null mice. Similarly, rifampin induced CYP3A in either wild-type or glucocorticoid receptor-null mice. Despite reports that rifampin is a nonsteroidal ligand for the human glucocorticoid receptor, rifampin failed to induce tyrosine aminotransferase in mice regardless of glucocorticoid receptor genotype, and rifampin did not compete for ligand binding to either mouse or human glucocorticoid receptor. Phenobarbital induced CYP3A, CYP2B, and P-450 reductase in all mice, but the amplitude of induction was diminished 37% in glucocorticoid receptor-null mice. Thus, there are distinctly different essential requirements of CYP3A, CYP2B, and P-450 reductase genes for the glucocorticoid receptor in their induction by steroids and drugs." @default.
• W2137722420 created "2016-06-24" @default.
• W2137722420 creator A5012663330 @default.
• W2137722420 creator A5021070991 @default.
• W2137722420 creator A5033349799 @default.
• W2137722420 creator A5047224062 @default.
• W2137722420 creator A5052790628 @default.
• W2137722420 creator A5061173143 @default.
• W2137722420 creator A5061234954 @default.
• W2137722420 creator A5068228886 @default.
• W2137722420 creator A5074421157 @default.
• W2137722420 date "2000-03-01" @default.
• W2137722420 modified "2023-09-27" @default.
• W2137722420 title "The glucocorticoid receptor is essential for induction of cytochrome P-4502B by steroids but not for drug or steroid induction of CYP3A or P-450 reductase in mouse liver." @default.
• W2137722420 cites W1501928068 @default.
• W2137722420 cites W1547215364 @default.
• W2137722420 cites W1553151860 @default.
• W2137722420 cites W1577828799 @default.
• W2137722420 cites W1832083730 @default.
• W2137722420 cites W1912379293 @default.
• W2137722420 cites W1963957404 @default.
• W2137722420 cites W1964090685 @default.
• W2137722420 cites W1965003306 @default.
• W2137722420 cites W1973238763 @default.
• W2137722420 cites W1980341403 @default.
• W2137722420 cites W1983398711 @default.
• W2137722420 cites W1984993582 @default.
• W2137722420 cites W1990330754 @default.
• W2137722420 cites W1997510672 @default.
• W2137722420 cites W2003116117 @default.
• W2137722420 cites W2005726728 @default.
• W2137722420 cites W2007140214 @default.
• W2137722420 cites W2011030679 @default.
• W2137722420 cites W2011163792 @default.
• W2137722420 cites W2019349841 @default.
• W2137722420 cites W2023057865 @default.
• W2137722420 cites W2023320084 @default.
• W2137722420 cites W2032177410 @default.
• W2137722420 cites W2035000881 @default.
• W2137722420 cites W2036776010 @default.
• W2137722420 cites W2046958176 @default.
• W2137722420 cites W2054747029 @default.
• W2137722420 cites W2056715229 @default.
• W2137722420 cites W2066838224 @default.
• W2137722420 cites W2068246413 @default.
• W2137722420 cites W2070165717 @default.
• W2137722420 cites W2075647807 @default.
• W2137722420 cites W2076682110 @default.
• W2137722420 cites W2080352301 @default.
• W2137722420 cites W2083568245 @default.
• W2137722420 cites W2084462922 @default.
• W2137722420 cites W2099762457 @default.
• W2137722420 cites W2101564676 @default.
• W2137722420 cites W2112632255 @default.
• W2137722420 cites W2128610046 @default.
• W2137722420 cites W2135248587 @default.
• W2137722420 cites W2157906581 @default.
• W2137722420 cites W2303281967 @default.
• W2137722420 cites W2316432578 @default.
• W2137722420 cites W2336328967 @default.
• W2137722420 cites W2340774400 @default.
• W2137722420 cites W2341636685 @default.
• W2137722420 cites W2414618063 @default.
• W2137722420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10681370" @default.
• W2137722420 hasPublicationYear "2000" @default.
• W2137722420 type Work @default.
• W2137722420 sameAs 2137722420 @default.
• W2137722420 citedByCount "26" @default.
• W2137722420 countsByYear W21377224202012 @default.
• W2137722420 countsByYear W21377224202014 @default.
• W2137722420 countsByYear W21377224202015 @default.
• W2137722420 countsByYear W21377224202016 @default.
• W2137722420 countsByYear W21377224202018 @default.
• W2137722420 countsByYear W21377224202020 @default.
• W2137722420 countsByYear W21377224202022 @default.
• W2137722420 crossrefType "journal-article" @default.
• W2137722420 hasAuthorship W2137722420A5012663330 @default.
• W2137722420 hasAuthorship W2137722420A5021070991 @default.
• W2137722420 hasAuthorship W2137722420A5033349799 @default.
• W2137722420 hasAuthorship W2137722420A5047224062 @default.
• W2137722420 hasAuthorship W2137722420A5052790628 @default.
• W2137722420 hasAuthorship W2137722420A5061173143 @default.
• W2137722420 hasAuthorship W2137722420A5061234954 @default.
• W2137722420 hasAuthorship W2137722420A5068228886 @default.
• W2137722420 hasAuthorship W2137722420A5074421157 @default.
• W2137722420 hasConcept C104317684 @default.
• W2137722420 hasConcept C11824378 @default.
• W2137722420 hasConcept C126322002 @default.
• W2137722420 hasConcept C132040763 @default.
• W2137722420 hasConcept C134018914 @default.
• W2137722420 hasConcept C170493617 @default.
• W2137722420 hasConcept C193264327 @default.
• W2137722420 hasConcept C2778826759 @default.
• W2137722420 hasConcept C2779234561 @default.
• W2137722420 hasConcept C2780193516 @default.
• W2137722420 hasConcept C2780841215 @default.
• W2137722420 hasConcept C2780902042 @default.
• W2137722420 hasConcept C526171541 @default.

• next