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- W2137728462 abstract "The crude methanol extract of <i>Dracaena arborea</i> leaves induced significant (p<0.01) increase in the clotting times of 21 ± 0.54 sec and 25 ± 1.1 sec at 5% and 10% concentrations of the extract respectively compared to the baseline clotting time of 7 ± 0.63 sec for the blood sample. The extract also exhibited potent <i>in vivo</i> and<i> in vitro</i> anticoagulant activities. Increased doses (100 and 200 mg/kg) of the extract, heparin (0.75 and 1.5 mg/kg) and aspirin (1.0 and 2.0 mg/kg) were found to have significantly (p < 0.01) prolonged the mean bleeding times with respect to the baseline in rabbits. However, in thrombin-induced clotting assay, the extract demonstrated a reduced potency compared to heparin. DPPH (1, 1-Diphenyl-2-picrylhydrazyl) and FRAP (Ferric reducing/antioxidant power) spetrophotometric assays revealed that the crude leaf extract possesses appreciable high antioxidant potentials. <i>Dracaena arborea</i> leaves (Wild.) Link could be a source of novel anticoagulant and antioxidant compounds for the management of various hematological disorders." @default.
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- W2137728462 date "2013-10-17" @default.
- W2137728462 modified "2023-09-25" @default.
- W2137728462 title "Anticoagulant and Antioxidant Activities of <i>Dracaena </i><i>a</i><i>rborea</i> Leaves (Wild.) Link" @default.
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- W2137728462 doi "https://doi.org/10.12691/ajbr-1-4-4" @default.
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