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- W2137751024 startingPage "131" @default.
- W2137751024 abstract "Summary: The T-cell receptor (TCR) α/σ locus includes a large number of V, D, J and C gene segments that are used lo produce functional TCR 8 and TCR a chains expressed by distinct subsets of T lymphocytes. V(D)J recombination events within the locus are regulated as a function of developmental stage and cell lineage during T-lymphocyte differentiation in the thymus. The process of V(D)J recombination is regulated by cis-acting elements that modulate the accessibility of chromosomal substrates to the recombinase. Here we evaluate how the assembly of transcription factor complexes onto enhancers, promoters and other regulatory elements within the TCR α/σ locus imparts developmental control to VDJσ and VJα rearrangement events. Furthermore, we develop the notion that within a complex locus such as the TCR α/σ locus, highly localized and region-specific control is likely to require an interplay between positive regulatory elements and blocking or boundary elements that restrict the influence of the positive elements to defined regions of the locus." @default.
- W2137751024 created "2016-06-24" @default.
- W2137751024 creator A5011304020 @default.
- W2137751024 creator A5035881186 @default.
- W2137751024 creator A5048430317 @default.
- W2137751024 creator A5075092692 @default.
- W2137751024 creator A5078854758 @default.
- W2137751024 creator A5088455217 @default.
- W2137751024 date "1998-10-01" @default.
- W2137751024 modified "2023-10-12" @default.
- W2137751024 title "Developmental regulation of V(D)J recombination at the TCR a/5 locus" @default.
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