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• W2137752381 abstract "The Brain derived neurotrophic factor (BDNF) is critically involved in neuroplasticity as well as the acquisition, consolidation, and retention of hippocampal- and amygdala-dependent learning. A common functional A→G single nucleotide polymorphism (BDNFval66met) in the pro-domain of the human BDNF gene is associated with abnormal intracellular trafficking and reduced activity-dependent BDNF release. We studied the effect of BDNFval66met in an aversive differential fear conditioning, and a delayed extinction paradigm in fifty-seven healthy participants. Pictures of male faces were used as stimuli and fear learning was quantified by fear potentiated startle (FPS) and skin conductance responses (SCR).Aware BDNF met-carriers show a behavioral deficit in amygdala-dependent fear conditioning as indicated by an absence of FPS responses in the last acquisition block. This deficit was maintained in the first block of extinction. No genotype differences were found in conditioned SCR discrimination. These data provide evidence for the involvement of BDNF signaling in human amygdala-dependent learning. We suggest that the BDNF met-allele may have a protective effect for the development of affective pathologies that is mediated via reduced synaptic plasticity induced by negative experience." @default.
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• W2137752381 date "2010-01-01" @default.
• W2137752381 modified "2023-10-17" @default.
• W2137752381 title "Amygdala-dependent fear conditioning in humans is modulated by the BDNFval66met polymorphism." @default.
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• W2137752381 doi "https://doi.org/10.1037/a0018261" @default.
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