Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137752893> ?p ?o ?g. }
- W2137752893 endingPage "407" @default.
- W2137752893 startingPage "391" @default.
- W2137752893 abstract "Allometric scaling is widely used to predict human pharmacokinetic parameters from preclinical species, and many different approaches have been proposed over the years to improve its predictive performance. Nevertheless, prediction errors are commonly observed in the practical application of simple allometry, for example, in cases where the hepatic metabolic clearance is mainly determined by enzyme activities, which do not scale allometrically across species. Therefore, if good correlation was noted for some drugs, poor correlation was observed for others, highlighting the need for other conceptual approaches. Physiologically based pharmacokinetic (PBPK) models are now a well-established approach to conduct extrapolations across species and to generate simulations of pharmacokinetic profiles under various physiological conditions. While conventional pharmacokinetic models are defined by drug-related data themselves, PBPK models have richer information content and integrate information from various sources, including drug-dependent, physiological, and biological parameters as they vary in between species, subjects, or with age and disease state. Therefore, the biological and mechanistic bases of PBPK models allow the extrapolation of the kinetic behavior of drugs with regard to dose, route, and species. In addition, by providing a link between tissue concentrations and toxicological or pharmacological effects, PBPK modeling represents a framework for mechanistic pharmacokinetic-pharmacodynamic models." @default.
- W2137752893 created "2016-06-24" @default.
- W2137752893 creator A5021392198 @default.
- W2137752893 creator A5023365520 @default.
- W2137752893 creator A5025569401 @default.
- W2137752893 creator A5051886173 @default.
- W2137752893 creator A5053839182 @default.
- W2137752893 date "2009-07-15" @default.
- W2137752893 modified "2023-10-14" @default.
- W2137752893 title "Physiologically based pharmacokinetics (PBPK)" @default.
- W2137752893 cites W118005493 @default.
- W2137752893 cites W1542232001 @default.
- W2137752893 cites W1571923304 @default.
- W2137752893 cites W1601438838 @default.
- W2137752893 cites W1829786542 @default.
- W2137752893 cites W1965704067 @default.
- W2137752893 cites W1966880707 @default.
- W2137752893 cites W1968101595 @default.
- W2137752893 cites W1968457077 @default.
- W2137752893 cites W1970601907 @default.
- W2137752893 cites W1971263174 @default.
- W2137752893 cites W1979264461 @default.
- W2137752893 cites W1983931738 @default.
- W2137752893 cites W1984452104 @default.
- W2137752893 cites W1988861488 @default.
- W2137752893 cites W1989703312 @default.
- W2137752893 cites W1989927329 @default.
- W2137752893 cites W1991512646 @default.
- W2137752893 cites W1994206407 @default.
- W2137752893 cites W1995149714 @default.
- W2137752893 cites W2001381178 @default.
- W2137752893 cites W2008286529 @default.
- W2137752893 cites W2009858196 @default.
- W2137752893 cites W2011656904 @default.
- W2137752893 cites W2013146296 @default.
- W2137752893 cites W2013258146 @default.
- W2137752893 cites W2014065104 @default.
- W2137752893 cites W2014332478 @default.
- W2137752893 cites W2014965485 @default.
- W2137752893 cites W2016167200 @default.
- W2137752893 cites W2017218221 @default.
- W2137752893 cites W2017744469 @default.
- W2137752893 cites W2019306159 @default.
- W2137752893 cites W2021872392 @default.
- W2137752893 cites W2022314390 @default.
- W2137752893 cites W2022463947 @default.
- W2137752893 cites W2028165836 @default.
- W2137752893 cites W2029590089 @default.
- W2137752893 cites W2031742675 @default.
- W2137752893 cites W2036314575 @default.
- W2137752893 cites W2039250788 @default.
- W2137752893 cites W2039537195 @default.
- W2137752893 cites W2039539582 @default.
- W2137752893 cites W2041777107 @default.
- W2137752893 cites W2042099048 @default.
- W2137752893 cites W2042365192 @default.
- W2137752893 cites W2046726491 @default.
- W2137752893 cites W2051674641 @default.
- W2137752893 cites W2052925164 @default.
- W2137752893 cites W2054829418 @default.
- W2137752893 cites W2060201297 @default.
- W2137752893 cites W2064799851 @default.
- W2137752893 cites W2065457233 @default.
- W2137752893 cites W2067468321 @default.
- W2137752893 cites W2067740141 @default.
- W2137752893 cites W2079192244 @default.
- W2137752893 cites W2081378029 @default.
- W2137752893 cites W2083968585 @default.
- W2137752893 cites W2086598386 @default.
- W2137752893 cites W2087759076 @default.
- W2137752893 cites W2093008321 @default.
- W2137752893 cites W2097475597 @default.
- W2137752893 cites W2099474947 @default.
- W2137752893 cites W2101766372 @default.
- W2137752893 cites W2103377763 @default.
- W2137752893 cites W2109122105 @default.
- W2137752893 cites W2113830209 @default.
- W2137752893 cites W2113953460 @default.
- W2137752893 cites W2114464891 @default.
- W2137752893 cites W2114871267 @default.
- W2137752893 cites W2134794720 @default.
- W2137752893 cites W2135772015 @default.
- W2137752893 cites W2138212930 @default.
- W2137752893 cites W2146393360 @default.
- W2137752893 cites W2149429360 @default.
- W2137752893 cites W2156445661 @default.
- W2137752893 cites W2158240950 @default.
- W2137752893 cites W2158370558 @default.
- W2137752893 cites W2165334931 @default.
- W2137752893 cites W2168235332 @default.
- W2137752893 cites W2170779955 @default.
- W2137752893 cites W2183315284 @default.
- W2137752893 cites W2270474355 @default.
- W2137752893 cites W321509503 @default.
- W2137752893 cites W4230626870 @default.
- W2137752893 cites W52274533 @default.
- W2137752893 cites W68169567 @default.
- W2137752893 doi "https://doi.org/10.1080/10837450902891360" @default.