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- W2137766667 abstract "Goggin PM, Northfield TC, Spychal RT. Factors affecting gastric mucosal hydrophobi city in man. Scand J Gastroenterol 1991, 26(suppl 181), 65–73Contact angle measurements in animal studies have demonstrated that gastric mucosa has a relatively hydrophobic surface. We have developed and validated a technique for the measurement of this property on human endoscopic biopsy specimens. Mean contact angle of the gastric body (70°) and antrum (70°) was higher than the duodenal bulb (62°; p < 0.01) and distal duodenum (50°; p < 0.001). Subjects with duodenal ulcer and gastric ulcer had a lower contact angle than controls without ulcer (57°, n = 49, and 59°, n = 17 versus 66°, n = 124, respectively). Helicobacter pylori infection was associated with reduced contact angle in subjects with gastritis (59° versus 68°). The contact angle was unchanged after treatment with ranitidine but increased to control values after clearance and eradication of H. pylori with bismuth and antibiotics. Incccatients, the contact angle was reduced and correlated negatively with the bile acid content of gastric juice (r = 0.51, p< 0.0001). We conclude that in man gastric mucosal hydrophobicity can be validly measured on endoscopic biopsy specimens and that it is high in health and reduced in bile reflux and in peptic ulcer disease, largely as a result of H. pylori infection." @default.
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- W2137766667 date "1991-01-01" @default.
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- W2137766667 title "Factors Affecting Gastric Mucosal Hydrophobi city in Man" @default.
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- W2137766667 doi "https://doi.org/10.3109/00365529109093210" @default.
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