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- W2137777210 abstract "Improved methods are needed for routine, inexpensive monitoring of biomarkers that could facilitate earlier detection and characterization of cancer. Suspended microchannel resonators (SMRs) are highly sensitive, batch-fabricated microcantilevers with embedded microchannels that can directly quantify adsorbed mass via changes in resonant frequency. As in other label-free detection methods, biomolecular measurements in complex media such as serum are challenging due to high background signals from nonspecific binding. In this report, we demonstrate that carboxybetaine-derived polymers developed to adsorb directly onto SMR SiO(2) surfaces act as ultralow fouling and functionalizable surface coatings. Coupled with a reference microcantilever, this approach enables detection of activated leukocyte cell adhesion molecule (ALCAM), a model cancer biomarker, in undiluted serum with a limit of detection of 10 ng/mL." @default.
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- W2137777210 date "2010-02-11" @default.
- W2137777210 modified "2023-10-18" @default.
- W2137777210 title "Label-Free Biomarker Sensing in Undiluted Serum with Suspended Microchannel Resonators" @default.
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- W2137777210 doi "https://doi.org/10.1021/ac9027356" @default.
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