FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137780330> ?p ?o ?g. }

• W2137780330 abstract "The computational methods provide condition for investigation related to the process of drug delivery, such as convection and diffusion of drug in extracellular matrices, drug extravasation from microvessels or to lymphatic vessels. The information of this process clarifies the mechanisms of drug delivery from the injection site to absorption by a solid tumor. In this study, an advanced numerical method is used to solve fluid flow and solute transport equations simultaneously to investigate the effect of tumor shape and size on drug delivery to solid tumor. The advanced mathematical model used in our previous work is further developed by adding solute transport equation to the governing equations. After applying appropriate boundary and initial conditions on tumor and surrounding tissue geometry, the element-based finite volume method is used for solving governing equations of drug delivery in solid tumor. Also, the effects of size and shape of tumor and some of tissue transport parameters such as effective pressure and hydraulic conductivity on interstitial fluid flow and drug delivery are investigated. Sensitivity analysis shows that drug delivery in prolate shape is significantly better than other tumor shapes. Considering size effect, increasing tumor size decreases drug concentration in interstitial fluid. This study shows that dependency of drug concentration in interstitial fluid to osmotic and intravascular pressure is negligible. This study shows that among diffusion and convection mechanisms of drug transport, diffusion is dominant in most different tumor shapes and sizes. In tumors in which the convection has considerable effect, the drug concentration is larger than that of other tumors at the same time post injection." @default.
• W2137780330 created "2016-06-24" @default.
• W2137780330 creator A5002315198 @default.
• W2137780330 creator A5002737611 @default.
• W2137780330 creator A5021756189 @default.
• W2137780330 creator A5026191305 @default.
• W2137780330 creator A5042529202 @default.
• W2137780330 creator A5050409814 @default.
• W2137780330 date "2014-06-12" @default.
• W2137780330 modified "2023-10-12" @default.
• W2137780330 title "Effect of tumor shape, size, and tissue transport properties on drug delivery to solid tumors" @default.
• W2137780330 cites W1480585619 @default.
• W2137780330 cites W1504011557 @default.
• W2137780330 cites W1965319984 @default.
• W2137780330 cites W1970233014 @default.
• W2137780330 cites W1982369490 @default.
• W2137780330 cites W1982435395 @default.
• W2137780330 cites W1987060944 @default.
• W2137780330 cites W1987451510 @default.
• W2137780330 cites W1992315099 @default.
• W2137780330 cites W2001215365 @default.
• W2137780330 cites W2026121478 @default.
• W2137780330 cites W2036274724 @default.
• W2137780330 cites W2037969499 @default.
• W2137780330 cites W2041337540 @default.
• W2137780330 cites W2045947409 @default.
• W2137780330 cites W2046981853 @default.
• W2137780330 cites W2052672777 @default.
• W2137780330 cites W2055009621 @default.
• W2137780330 cites W2055384999 @default.
• W2137780330 cites W2059202400 @default.
• W2137780330 cites W2066724170 @default.
• W2137780330 cites W2067931274 @default.
• W2137780330 cites W2070222238 @default.
• W2137780330 cites W2081054963 @default.
• W2137780330 cites W2083280522 @default.
• W2137780330 cites W2085759889 @default.
• W2137780330 cites W2094794373 @default.
• W2137780330 cites W2098469356 @default.
• W2137780330 cites W2104282171 @default.
• W2137780330 cites W2104957192 @default.
• W2137780330 cites W2106979625 @default.
• W2137780330 cites W2107907914 @default.
• W2137780330 cites W2126163864 @default.
• W2137780330 cites W2128253222 @default.
• W2137780330 cites W2128765685 @default.
• W2137780330 cites W2139626150 @default.
• W2137780330 cites W2158503340 @default.
• W2137780330 cites W2161817637 @default.
• W2137780330 cites W2256545339 @default.
• W2137780330 cites W2335410441 @default.
• W2137780330 cites W4246544625 @default.
• W2137780330 doi "https://doi.org/10.1186/1754-1611-8-12" @default.
• W2137780330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4076317" @default.
• W2137780330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24987457" @default.
• W2137780330 hasPublicationYear "2014" @default.
• W2137780330 type Work @default.
• W2137780330 sameAs 2137780330 @default.
• W2137780330 citedByCount "99" @default.
• W2137780330 countsByYear W21377803302014 @default.
• W2137780330 countsByYear W21377803302015 @default.
• W2137780330 countsByYear W21377803302016 @default.
• W2137780330 countsByYear W21377803302017 @default.
• W2137780330 countsByYear W21377803302018 @default.
• W2137780330 countsByYear W21377803302019 @default.
• W2137780330 countsByYear W21377803302020 @default.
• W2137780330 countsByYear W21377803302021 @default.
• W2137780330 countsByYear W21377803302022 @default.
• W2137780330 countsByYear W21377803302023 @default.
• W2137780330 crossrefType "journal-article" @default.
• W2137780330 hasAuthorship W2137780330A5002315198 @default.
• W2137780330 hasAuthorship W2137780330A5002737611 @default.
• W2137780330 hasAuthorship W2137780330A5021756189 @default.
• W2137780330 hasAuthorship W2137780330A5026191305 @default.
• W2137780330 hasAuthorship W2137780330A5042529202 @default.
• W2137780330 hasAuthorship W2137780330A5050409814 @default.
• W2137780330 hasBestOaLocation W21377803301 @default.
• W2137780330 hasConcept C10899652 @default.
• W2137780330 hasConcept C121332964 @default.
• W2137780330 hasConcept C136229726 @default.
• W2137780330 hasConcept C142724271 @default.
• W2137780330 hasConcept C171250308 @default.
• W2137780330 hasConcept C185592680 @default.
• W2137780330 hasConcept C192562407 @default.
• W2137780330 hasConcept C2779820397 @default.
• W2137780330 hasConcept C2779822359 @default.
• W2137780330 hasConcept C2780035454 @default.
• W2137780330 hasConcept C57879066 @default.
• W2137780330 hasConcept C69357855 @default.
• W2137780330 hasConcept C71924100 @default.
• W2137780330 hasConcept C97355855 @default.
• W2137780330 hasConcept C98274493 @default.
• W2137780330 hasConceptScore W2137780330C10899652 @default.
• W2137780330 hasConceptScore W2137780330C121332964 @default.
• W2137780330 hasConceptScore W2137780330C136229726 @default.
• W2137780330 hasConceptScore W2137780330C142724271 @default.
• W2137780330 hasConceptScore W2137780330C171250308 @default.
• W2137780330 hasConceptScore W2137780330C185592680 @default.
• W2137780330 hasConceptScore W2137780330C192562407 @default.
• W2137780330 hasConceptScore W2137780330C2779820397 @default.

• next