FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137788707> ?p ?o ?g. }

• W2137788707 endingPage "8309" @default.
• W2137788707 startingPage "8300" @default.
• W2137788707 abstract "Although the PI3K (phosphatidylinositol 3-kinase) pathway typically regulates cell growth and survival, increasing evidence indicates the involvement of this pathway in neural plasticity. It is unknown whether the PI3K pathway can mediate pain hypersensitivity. Intradermal injection of capsaicin and NGF produce heat hyperalgesia by activating their respective TRPV1 (transient receptor potential vanilloid receptor-1) and TrkA receptors on nociceptor sensory nerve terminals. We examined the activation of PI3K in primary sensory DRG neurons by these inflammatory agents and the contribution of PI3K activation to inflammatory pain. We further investigated the correlation between the PI3K and the ERK (extracellular signal-regulated protein kinase) pathway. Capsaicin and NGF induce phosphorylation of the PI3K downstream target AKT (protein kinase B), which is blocked by the PI3K inhibitors LY294002 and wortmannin, indicative of the activation of PI3K by both agents. ERK activation by capsaicin and NGF was also blocked by PI3K inhibitors. Similarly, intradermal capsaicin in rats activated PI3K and ERK in C-fiber DRG neurons and epidermal nerve fibers. Injection of PI3K or MEK (ERK kinase) inhibitors into the hindpaw attenuated capsaicin- and NGF-evoked heat hyperalgesia but did not change basal heat sensitivity. Furthermore, PI3K, but not ERK, inhibition blocked early induction of hyperalgesia. In acutely dissociated DRG neurons, the capsaicin-induced TRPV1 current was strikingly potentiated by NGF, and this potentiation was completely blocked by PI3K inhibitors and primarily suppressed by MEK inhibitors. Therefore, PI3K induces heat hyperalgesia, possibly by regulating TRPV1 activity, in an ERK-dependent manner. The PI3K pathway also appears to play a role that is distinct from ERK by regulating the early onset of inflammatory pain." @default.
• W2137788707 created "2016-06-24" @default.
• W2137788707 creator A5015333343 @default.
• W2137788707 creator A5027063134 @default.
• W2137788707 creator A5037718871 @default.
• W2137788707 creator A5086060042 @default.
• W2137788707 date "2004-09-22" @default.
• W2137788707 modified "2023-10-17" @default.
• W2137788707 title "Phosphatidylinositol 3-Kinase Activates ERK in Primary Sensory Neurons and Mediates Inflammatory Heat Hyperalgesia through TRPV1 Sensitization" @default.
• W2137788707 cites W124215553 @default.
• W2137788707 cites W1492591187 @default.
• W2137788707 cites W1511198581 @default.
• W2137788707 cites W1513944968 @default.
• W2137788707 cites W1529396499 @default.
• W2137788707 cites W1566814755 @default.
• W2137788707 cites W1568605582 @default.
• W2137788707 cites W1583540378 @default.
• W2137788707 cites W1595049684 @default.
• W2137788707 cites W1638203569 @default.
• W2137788707 cites W1670760110 @default.
• W2137788707 cites W1817439804 @default.
• W2137788707 cites W1841303832 @default.
• W2137788707 cites W1877154941 @default.
• W2137788707 cites W1883044208 @default.
• W2137788707 cites W1893308746 @default.
• W2137788707 cites W1919059205 @default.
• W2137788707 cites W1954419182 @default.
• W2137788707 cites W1963857381 @default.
• W2137788707 cites W1964486755 @default.
• W2137788707 cites W1965516341 @default.
• W2137788707 cites W1969782353 @default.
• W2137788707 cites W1971727526 @default.
• W2137788707 cites W1971754431 @default.
• W2137788707 cites W1973556415 @default.
• W2137788707 cites W1990264946 @default.
• W2137788707 cites W1995705528 @default.
• W2137788707 cites W1997308301 @default.
• W2137788707 cites W2002127663 @default.
• W2137788707 cites W2003266871 @default.
• W2137788707 cites W2003404396 @default.
• W2137788707 cites W2004071649 @default.
• W2137788707 cites W2009967312 @default.
• W2137788707 cites W2011540368 @default.
• W2137788707 cites W2014007136 @default.
• W2137788707 cites W2017292900 @default.
• W2137788707 cites W2017299181 @default.
• W2137788707 cites W2021565244 @default.
• W2137788707 cites W2022539526 @default.
• W2137788707 cites W2027256301 @default.
• W2137788707 cites W2027496708 @default.
• W2137788707 cites W2028067698 @default.
• W2137788707 cites W2029993965 @default.
• W2137788707 cites W2030102659 @default.
• W2137788707 cites W2033801757 @default.
• W2137788707 cites W2037390298 @default.
• W2137788707 cites W2040664792 @default.
• W2137788707 cites W2042295311 @default.
• W2137788707 cites W2043878742 @default.
• W2137788707 cites W2044712342 @default.
• W2137788707 cites W2045441934 @default.
• W2137788707 cites W2050781058 @default.
• W2137788707 cites W2054414022 @default.
• W2137788707 cites W2055804358 @default.
• W2137788707 cites W2063103796 @default.
• W2137788707 cites W2068225015 @default.
• W2137788707 cites W2069941772 @default.
• W2137788707 cites W2078828516 @default.
• W2137788707 cites W2094412568 @default.
• W2137788707 cites W2100997560 @default.
• W2137788707 cites W2101573249 @default.
• W2137788707 cites W2103002807 @default.
• W2137788707 cites W2105493663 @default.
• W2137788707 cites W2108158812 @default.
• W2137788707 cites W2114842668 @default.
• W2137788707 cites W2117506103 @default.
• W2137788707 cites W2119832782 @default.
• W2137788707 cites W2124290176 @default.
• W2137788707 cites W2128134322 @default.
• W2137788707 cites W2133316133 @default.
• W2137788707 cites W2133543836 @default.
• W2137788707 cites W2134742719 @default.
• W2137788707 cites W2147114673 @default.
• W2137788707 cites W2149085099 @default.
• W2137788707 cites W2153068303 @default.
• W2137788707 cites W2156783552 @default.
• W2137788707 cites W2159953124 @default.
• W2137788707 cites W2161070224 @default.
• W2137788707 cites W2161455727 @default.
• W2137788707 cites W2170891211 @default.
• W2137788707 cites W2321684900 @default.
• W2137788707 cites W4296759766 @default.
• W2137788707 doi "https://doi.org/10.1523/jneurosci.2893-04.2004" @default.
• W2137788707 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6729698" @default.
• W2137788707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15385613" @default.
• W2137788707 hasPublicationYear "2004" @default.
• W2137788707 type Work @default.
• W2137788707 sameAs 2137788707 @default.
• W2137788707 citedByCount "377" @default.

• next