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• W2137790969 abstract "The antitumor agent carminic acid 1a does not bind to DNA but nicks it slowly, more rapidly when reduced in situ, and still more rapidly when prereduced at the quinone moiety. The nicking process requires oxygen and is selectively inhibited by (i) superoxide dismutase, (ii) catalase, and (iii) free radical scavengers indicating the involvement of O2•, H2O2, and OH., respectively. The intermediacy of OH. was supported by spin trapping with N-t-butyl-α-phenylnitrone and epr of the radical produced via the carminic acid semiquinone. The single strand scission of DNA by carminic acid requires two adjacent hydroquinone moieties in the chromophore since reduced methyl tetra-O-methylcarminate 1b is without effect although it binds weakly to DNA. Polarographic redox potentials for the reversible (2e, 2H+) reduction of 1a and 1b are −0.736 ± 0.003 V and −0.56 ± 0.010 V against SCE, respectively. The fact that daunorubicin and adriamycin produce more extensive DNA strand scission than carminic acid under comparable conditions of prereduction and on a molar basis is largely attributed to the assistance of intercalative binding afforded in the case of the anthracyclines." @default.
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• W2137790969 date "1979-03-01" @default.
• W2137790969 modified "2023-09-26" @default.
• W2137790969 title "Reactions of the antitumor agent carminic acid and derivatives with DNA" @default.
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• W2137790969 doi "https://doi.org/10.1016/0045-2068(79)90032-4" @default.
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