Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137807130> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2137807130 endingPage "323" @default.
- W2137807130 startingPage "317" @default.
- W2137807130 abstract "Sixteen subjects completed an open-label study designed to assess the effect of renal impairment on the disposition of cibenzoline. The study included 10 patients with mild or moderate renal impairment creatinine clearance <60 ml/min/70 kg) and six healthy subjects in the same age range, each of whom received a single 130 mg oral dose of cibenzoline. The pharmacokinetic parameters observed in the healthy volunteers were similar to those reported previously. Maximum plasma concentration, time of maximum concentration, and apparent volume of distribution after single doses in patients with renal impairment were in the same range as those observed in healthy volunteers. The elimination half-life increased with decreasing renal function from a mean value of approximately 8 hours in healthy volunteers to more than 20 hours in patients with moderate renal impairment. Renal clearance and the fraction of the dose excreted unchanged in the urine decreased with decreasing creatinine clearance. The results of this study suggest that the dosage of cibenzoline should be reduced or the dosage interval increased in patients with reduced renal function to avoid excessive drug accumulation. Clinical Pharmacology and Therapeutics (1988) 43, 317–323; doi:10.1038/clpt.1988.38" @default.
- W2137807130 created "2016-06-24" @default.
- W2137807130 creator A5014245128 @default.
- W2137807130 creator A5027675893 @default.
- W2137807130 creator A5029564912 @default.
- W2137807130 creator A5036069822 @default.
- W2137807130 creator A5087493829 @default.
- W2137807130 creator A5091088724 @default.
- W2137807130 date "1988-03-01" @default.
- W2137807130 modified "2023-10-16" @default.
- W2137807130 title "Effect of renal impairment on the pharmacokinetics of cibenzoline" @default.
- W2137807130 doi "https://doi.org/10.1038/clpt.1988.38" @default.
- W2137807130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3345622" @default.
- W2137807130 hasPublicationYear "1988" @default.
- W2137807130 type Work @default.
- W2137807130 sameAs 2137807130 @default.
- W2137807130 citedByCount "14" @default.
- W2137807130 countsByYear W21378071302021 @default.
- W2137807130 crossrefType "journal-article" @default.
- W2137807130 hasAuthorship W2137807130A5014245128 @default.
- W2137807130 hasAuthorship W2137807130A5027675893 @default.
- W2137807130 hasAuthorship W2137807130A5029564912 @default.
- W2137807130 hasAuthorship W2137807130A5036069822 @default.
- W2137807130 hasAuthorship W2137807130A5087493829 @default.
- W2137807130 hasAuthorship W2137807130A5091088724 @default.
- W2137807130 hasConcept C112705442 @default.
- W2137807130 hasConcept C126322002 @default.
- W2137807130 hasConcept C126894567 @default.
- W2137807130 hasConcept C138944611 @default.
- W2137807130 hasConcept C139254425 @default.
- W2137807130 hasConcept C142225936 @default.
- W2137807130 hasConcept C159641895 @default.
- W2137807130 hasConcept C177669144 @default.
- W2137807130 hasConcept C21652263 @default.
- W2137807130 hasConcept C2780026642 @default.
- W2137807130 hasConcept C2780306776 @default.
- W2137807130 hasConcept C63433958 @default.
- W2137807130 hasConcept C71924100 @default.
- W2137807130 hasConcept C98274493 @default.
- W2137807130 hasConceptScore W2137807130C112705442 @default.
- W2137807130 hasConceptScore W2137807130C126322002 @default.
- W2137807130 hasConceptScore W2137807130C126894567 @default.
- W2137807130 hasConceptScore W2137807130C138944611 @default.
- W2137807130 hasConceptScore W2137807130C139254425 @default.
- W2137807130 hasConceptScore W2137807130C142225936 @default.
- W2137807130 hasConceptScore W2137807130C159641895 @default.
- W2137807130 hasConceptScore W2137807130C177669144 @default.
- W2137807130 hasConceptScore W2137807130C21652263 @default.
- W2137807130 hasConceptScore W2137807130C2780026642 @default.
- W2137807130 hasConceptScore W2137807130C2780306776 @default.
- W2137807130 hasConceptScore W2137807130C63433958 @default.
- W2137807130 hasConceptScore W2137807130C71924100 @default.
- W2137807130 hasConceptScore W2137807130C98274493 @default.
- W2137807130 hasIssue "3" @default.
- W2137807130 hasLocation W21378071301 @default.
- W2137807130 hasLocation W21378071302 @default.
- W2137807130 hasOpenAccess W2137807130 @default.
- W2137807130 hasPrimaryLocation W21378071301 @default.
- W2137807130 hasRelatedWork W104872609 @default.
- W2137807130 hasRelatedWork W2030585667 @default.
- W2137807130 hasRelatedWork W2069980166 @default.
- W2137807130 hasRelatedWork W2133100232 @default.
- W2137807130 hasRelatedWork W2149820792 @default.
- W2137807130 hasRelatedWork W2268601721 @default.
- W2137807130 hasRelatedWork W2400700397 @default.
- W2137807130 hasRelatedWork W2413530128 @default.
- W2137807130 hasRelatedWork W2438481870 @default.
- W2137807130 hasRelatedWork W2787754251 @default.
- W2137807130 hasVolume "43" @default.
- W2137807130 isParatext "false" @default.
- W2137807130 isRetracted "false" @default.
- W2137807130 magId "2137807130" @default.
- W2137807130 workType "article" @default.