Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137818625> ?p ?o ?g. }
- W2137818625 endingPage "467" @default.
- W2137818625 startingPage "453" @default.
- W2137818625 abstract "Beta cell connectivity describes the phenomenon whereby the islet context improves insulin secretion by providing a three-dimensional platform for intercellular signaling processes. Thus, the precise flow of information through homotypically interconnected beta cells leads to the large-scale organization of hormone release activities, influencing cell responses to glucose and other secretagogues. Although a phenomenon whose importance has arguably been underappreciated in islet biology until recently, a growing number of studies suggest that such cell–cell communication is a fundamental property of this micro-organ. Hence, connectivity may plausibly be targeted by both environmental and genetic factors in type 2 diabetes mellitus (T2DM) to perturb normal beta cell function and insulin release. Here, we review the mechanisms that contribute to beta cell connectivity, discuss how these may fail during T2DM, and examine approaches to restore insulin secretion by boosting cell communication." @default.
- W2137818625 created "2016-06-24" @default.
- W2137818625 creator A5015737554 @default.
- W2137818625 creator A5039784437 @default.
- W2137818625 date "2014-10-17" @default.
- W2137818625 modified "2023-10-09" @default.
- W2137818625 title "Beta cell connectivity in pancreatic islets: a type 2 diabetes target?" @default.
- W2137818625 cites W1498387589 @default.
- W2137818625 cites W1502195451 @default.
- W2137818625 cites W1531888366 @default.
- W2137818625 cites W1554796897 @default.
- W2137818625 cites W1590107056 @default.
- W2137818625 cites W1605676490 @default.
- W2137818625 cites W1788294099 @default.
- W2137818625 cites W1943482912 @default.
- W2137818625 cites W1964969494 @default.
- W2137818625 cites W1966650637 @default.
- W2137818625 cites W1967695195 @default.
- W2137818625 cites W1968382234 @default.
- W2137818625 cites W1968498807 @default.
- W2137818625 cites W1968820250 @default.
- W2137818625 cites W1969359749 @default.
- W2137818625 cites W1969914617 @default.
- W2137818625 cites W1969932276 @default.
- W2137818625 cites W1970893100 @default.
- W2137818625 cites W1972051140 @default.
- W2137818625 cites W1973045246 @default.
- W2137818625 cites W1973194781 @default.
- W2137818625 cites W1977200545 @default.
- W2137818625 cites W1980744914 @default.
- W2137818625 cites W1981493238 @default.
- W2137818625 cites W1982324050 @default.
- W2137818625 cites W1985117435 @default.
- W2137818625 cites W1990044372 @default.
- W2137818625 cites W1991003148 @default.
- W2137818625 cites W1991201281 @default.
- W2137818625 cites W1992561101 @default.
- W2137818625 cites W1992898823 @default.
- W2137818625 cites W1994924615 @default.
- W2137818625 cites W1995196662 @default.
- W2137818625 cites W1995213405 @default.
- W2137818625 cites W1995536774 @default.
- W2137818625 cites W1996669620 @default.
- W2137818625 cites W1999653836 @default.
- W2137818625 cites W2004977380 @default.
- W2137818625 cites W2008620264 @default.
- W2137818625 cites W2010174774 @default.
- W2137818625 cites W2014131324 @default.
- W2137818625 cites W2015316095 @default.
- W2137818625 cites W2017231055 @default.
- W2137818625 cites W2019020805 @default.
- W2137818625 cites W2019077674 @default.
- W2137818625 cites W2019283908 @default.
- W2137818625 cites W2021701700 @default.
- W2137818625 cites W2022868895 @default.
- W2137818625 cites W2026444172 @default.
- W2137818625 cites W2028641524 @default.
- W2137818625 cites W2030294790 @default.
- W2137818625 cites W2030713769 @default.
- W2137818625 cites W2035748369 @default.
- W2137818625 cites W2036434451 @default.
- W2137818625 cites W2036616984 @default.
- W2137818625 cites W2038020327 @default.
- W2137818625 cites W2039319647 @default.
- W2137818625 cites W2040746568 @default.
- W2137818625 cites W2041194353 @default.
- W2137818625 cites W2041422804 @default.
- W2137818625 cites W2044376455 @default.
- W2137818625 cites W2044413110 @default.
- W2137818625 cites W2045312491 @default.
- W2137818625 cites W2046913589 @default.
- W2137818625 cites W2049887628 @default.
- W2137818625 cites W2050213976 @default.
- W2137818625 cites W2053514165 @default.
- W2137818625 cites W2055057067 @default.
- W2137818625 cites W2057370821 @default.
- W2137818625 cites W2059298081 @default.
- W2137818625 cites W2059945390 @default.
- W2137818625 cites W2060302403 @default.
- W2137818625 cites W2061425021 @default.
- W2137818625 cites W2065220463 @default.
- W2137818625 cites W2065285024 @default.
- W2137818625 cites W2065430703 @default.
- W2137818625 cites W2066009496 @default.
- W2137818625 cites W2066399874 @default.
- W2137818625 cites W2066752848 @default.
- W2137818625 cites W2067387842 @default.
- W2137818625 cites W2068240122 @default.
- W2137818625 cites W2068364567 @default.
- W2137818625 cites W2068782608 @default.
- W2137818625 cites W2068892782 @default.
- W2137818625 cites W2072240385 @default.
- W2137818625 cites W2073312394 @default.
- W2137818625 cites W2074528335 @default.
- W2137818625 cites W2075877892 @default.
- W2137818625 cites W2076790692 @default.
- W2137818625 cites W2077409251 @default.
- W2137818625 cites W2080489534 @default.