FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137836161> ?p ?o ?g. }

• W2137836161 endingPage "208" @default.
• W2137836161 startingPage "200" @default.
• W2137836161 abstract "The anterior–posterior and dorsal–ventral progression of heart organogenesis is well illustrated by the patterning and activity of two members of different families of cell adhesion molecules: the calcium-dependent cadherins, specifically N-cadherin, and the extracellular matrix glycoproteins, fibronectin. N-cadherin by its binding to the intracellular molecule β-catenin and fibronectin by its binding to integrins at focal adhesion sites, are involved in regulation of gene expression by their association with the cytoskeleton and through signal transduction pathways. The ventral precardiac mesoderm cells epithelialize and become stably committed by the activation of these cell–matrix and intracellular signaling transduction pathways. Cross talk between the adhesion signaling pathways initiates the characteristic phenotypic changes associated with cardiomyocyte differentiation: electrical activity and organization of myofibrils. The development of both organ form and function occurs within a short interval thereafter. Mutations in any of the interacting molecules, or environmental insults affecting either of these signaling pathways, can result in embryonic lethality or fetuses born with severe heart defects. As an example, we have defined that exposure of the embryo temporally to lithium during an early sensitive developmental period affects a canonical Wnt pathway leading to β-catenin stabilization. Lithium exposure results in an anterior–posterior progression of severe cardiac defects." @default.
• W2137836161 created "2016-06-24" @default.
• W2137836161 creator A5001196534 @default.
• W2137836161 creator A5046852630 @default.
• W2137836161 creator A5073030423 @default.
• W2137836161 date "2005-05-12" @default.
• W2137836161 modified "2023-09-27" @default.
• W2137836161 title "Cross Talk between Cell–Cell and Cell–Matrix Adhesion Signaling Pathways during Heart Organogenesis: Implications for Cardiac Birth Defects" @default.
• W2137836161 cites W118396326 @default.
• W2137836161 cites W1513205519 @default.
• W2137836161 cites W1519072726 @default.
• W2137836161 cites W1597673292 @default.
• W2137836161 cites W1929969812 @default.
• W2137836161 cites W1964743891 @default.
• W2137836161 cites W1976094538 @default.
• W2137836161 cites W1979993283 @default.
• W2137836161 cites W1983130326 @default.
• W2137836161 cites W1983208899 @default.
• W2137836161 cites W1992046649 @default.
• W2137836161 cites W1993430180 @default.
• W2137836161 cites W1993869558 @default.
• W2137836161 cites W1994872919 @default.
• W2137836161 cites W1999758837 @default.
• W2137836161 cites W2008050996 @default.
• W2137836161 cites W2008319986 @default.
• W2137836161 cites W2009208130 @default.
• W2137836161 cites W2014574033 @default.
• W2137836161 cites W2015887548 @default.
• W2137836161 cites W2020597782 @default.
• W2137836161 cites W2032507383 @default.
• W2137836161 cites W2035213953 @default.
• W2137836161 cites W2039375742 @default.
• W2137836161 cites W2042884202 @default.
• W2137836161 cites W2048675800 @default.
• W2137836161 cites W2051788298 @default.
• W2137836161 cites W2053601630 @default.
• W2137836161 cites W2054799212 @default.
• W2137836161 cites W2056524045 @default.
• W2137836161 cites W2059128760 @default.
• W2137836161 cites W2060726822 @default.
• W2137836161 cites W2061977587 @default.
• W2137836161 cites W2064617375 @default.
• W2137836161 cites W2069052538 @default.
• W2137836161 cites W2075115547 @default.
• W2137836161 cites W2080796625 @default.
• W2137836161 cites W2084219905 @default.
• W2137836161 cites W2092664596 @default.
• W2137836161 cites W2106636692 @default.
• W2137836161 cites W2111072594 @default.
• W2137836161 cites W2112960344 @default.
• W2137836161 cites W2117608719 @default.
• W2137836161 cites W2120263914 @default.
• W2137836161 cites W2121530025 @default.
• W2137836161 cites W2122935465 @default.
• W2137836161 cites W2131042297 @default.
• W2137836161 cites W2140034535 @default.
• W2137836161 cites W2149961437 @default.
• W2137836161 cites W2150295764 @default.
• W2137836161 cites W2156490871 @default.
• W2137836161 cites W2159999909 @default.
• W2137836161 cites W2181579670 @default.
• W2137836161 cites W2188422153 @default.
• W2137836161 cites W2281992589 @default.
• W2137836161 cites W23320619 @default.
• W2137836161 cites W942438918 @default.
• W2137836161 doi "https://doi.org/10.1017/s1431927605050440" @default.
• W2137836161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16060972" @default.
• W2137836161 hasPublicationYear "2005" @default.
• W2137836161 type Work @default.
• W2137836161 sameAs 2137836161 @default.
• W2137836161 citedByCount "28" @default.
• W2137836161 countsByYear W21378361612013 @default.
• W2137836161 countsByYear W21378361612014 @default.
• W2137836161 countsByYear W21378361612016 @default.
• W2137836161 countsByYear W21378361612017 @default.
• W2137836161 countsByYear W21378361612018 @default.
• W2137836161 countsByYear W21378361612020 @default.
• W2137836161 countsByYear W21378361612021 @default.
• W2137836161 countsByYear W21378361612023 @default.
• W2137836161 crossrefType "journal-article" @default.
• W2137836161 hasAuthorship W2137836161A5001196534 @default.
• W2137836161 hasAuthorship W2137836161A5046852630 @default.
• W2137836161 hasAuthorship W2137836161A5073030423 @default.
• W2137836161 hasConcept C104317684 @default.
• W2137836161 hasConcept C137620995 @default.
• W2137836161 hasConcept C145103041 @default.
• W2137836161 hasConcept C1491633281 @default.
• W2137836161 hasConcept C149402561 @default.
• W2137836161 hasConcept C151166631 @default.
• W2137836161 hasConcept C16224149 @default.
• W2137836161 hasConcept C189165786 @default.
• W2137836161 hasConcept C195687474 @default.
• W2137836161 hasConcept C2780915607 @default.
• W2137836161 hasConcept C30503417 @default.
• W2137836161 hasConcept C54355233 @default.
• W2137836161 hasConcept C62478195 @default.
• W2137836161 hasConcept C85789140 @default.
• W2137836161 hasConcept C86492073 @default.

• next