FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137861587> ?p ?o ?g. }

• W2137861587 abstract "Background: Lysophospholipids such as lysophosphatidylcholine (LPC) have many direct electrophysiological effects on cardiac muscle and have been implicated as a cause of lethal ventricular arrhythmias during acute myocardial ischemia. Because extracellular K + accu mulation is also a key arrhythmogenic factor during acute ischemia, we examined the effects of LPC on cellular K + balance, including its interaction with adenosine triphosphate- sensitive K+ (K ATP ) channels. Methods and Results : Isolated rabbit interventricular septa paced at 75 beats/min were loaded with 42 K + to measure unidirectional K + efflux rate (in 42 K - washout experiments) or tissue K + content (in 42 K + uptake experiments) and action potential duration (APD) during exposure to 20 μM LPC for 30 minutes. LPC caused tissue K + content to decrease by 15 ± 2% (n = 4) at a steady rate over 30 minutes, associated with gradual APD shortening and a delayed increase in unidirectional K + efflux rate. Pretreatment with 12 μM cromakalim to selectively activate K ATP channels shortened APD by 44 ± 66% and had no effect on net tis sue K + content during control aerobic perfusion. However, cromakalim increased net K + loss during exposure to LPC to 22 ± 4%, a 47% increase. Conclusions: LPC induced net K loss in heart, which was potentiated by the K ATP channel agonist cromakalim. This ATP finding suggests that if LPC accumulates to similar levels during myocardial ischemia and hypoxia, it may be an important mechanism in net K + loss." @default.
• W2137861587 created "2016-06-24" @default.
• W2137861587 creator A5004178732 @default.
• W2137861587 creator A5009561014 @default.
• W2137861587 creator A5016941575 @default.
• W2137861587 creator A5086594801 @default.
• W2137861587 date "1998-03-01" @default.
• W2137861587 modified "2023-10-14" @default.
• W2137861587 title "Lysophosphatidylcholine and Cellular Potassium Loss in Isolated Rabbit Ventricle" @default.
• W2137861587 cites W1505323253 @default.
• W2137861587 cites W1971076950 @default.
• W2137861587 cites W1976558646 @default.
• W2137861587 cites W1990328055 @default.
• W2137861587 cites W1994747574 @default.
• W2137861587 cites W2005521082 @default.
• W2137861587 cites W2005893350 @default.
• W2137861587 cites W2005992020 @default.
• W2137861587 cites W2008873619 @default.
• W2137861587 cites W2012933064 @default.
• W2137861587 cites W2014775135 @default.
• W2137861587 cites W2024858633 @default.
• W2137861587 cites W2032366740 @default.
• W2137861587 cites W2037032916 @default.
• W2137861587 cites W2049445844 @default.
• W2137861587 cites W2060804739 @default.
• W2137861587 cites W2067552289 @default.
• W2137861587 cites W2082919007 @default.
• W2137861587 cites W2095149372 @default.
• W2137861587 cites W2136147069 @default.
• W2137861587 cites W2150990549 @default.
• W2137861587 cites W2153144629 @default.
• W2137861587 cites W2153856379 @default.
• W2137861587 cites W2162017134 @default.
• W2137861587 cites W2170679542 @default.
• W2137861587 cites W2413637559 @default.
• W2137861587 cites W2419714836 @default.
• W2137861587 doi "https://doi.org/10.1177/107424849800300105" @default.
• W2137861587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10684479" @default.
• W2137861587 hasPublicationYear "1998" @default.
• W2137861587 type Work @default.
• W2137861587 sameAs 2137861587 @default.
• W2137861587 citedByCount "7" @default.
• W2137861587 countsByYear W21378615872014 @default.
• W2137861587 countsByYear W21378615872016 @default.
• W2137861587 crossrefType "journal-article" @default.
• W2137861587 hasAuthorship W2137861587A5004178732 @default.
• W2137861587 hasAuthorship W2137861587A5009561014 @default.
• W2137861587 hasAuthorship W2137861587A5016941575 @default.
• W2137861587 hasAuthorship W2137861587A5086594801 @default.
• W2137861587 hasConcept C126322002 @default.
• W2137861587 hasConcept C134018914 @default.
• W2137861587 hasConcept C146957229 @default.
• W2137861587 hasConcept C164705383 @default.
• W2137861587 hasConcept C170493617 @default.
• W2137861587 hasConcept C185592680 @default.
• W2137861587 hasConcept C2776330855 @default.
• W2137861587 hasConcept C2776991684 @default.
• W2137861587 hasConcept C2778596009 @default.
• W2137861587 hasConcept C2778918659 @default.
• W2137861587 hasConcept C2778921608 @default.
• W2137861587 hasConcept C2778938600 @default.
• W2137861587 hasConcept C2780561956 @default.
• W2137861587 hasConcept C28406088 @default.
• W2137861587 hasConcept C41625074 @default.
• W2137861587 hasConcept C55493867 @default.
• W2137861587 hasConcept C71924100 @default.
• W2137861587 hasConcept C83743174 @default.
• W2137861587 hasConcept C98274493 @default.
• W2137861587 hasConceptScore W2137861587C126322002 @default.
• W2137861587 hasConceptScore W2137861587C134018914 @default.
• W2137861587 hasConceptScore W2137861587C146957229 @default.
• W2137861587 hasConceptScore W2137861587C164705383 @default.
• W2137861587 hasConceptScore W2137861587C170493617 @default.
• W2137861587 hasConceptScore W2137861587C185592680 @default.
• W2137861587 hasConceptScore W2137861587C2776330855 @default.
• W2137861587 hasConceptScore W2137861587C2776991684 @default.
• W2137861587 hasConceptScore W2137861587C2778596009 @default.
• W2137861587 hasConceptScore W2137861587C2778918659 @default.
• W2137861587 hasConceptScore W2137861587C2778921608 @default.
• W2137861587 hasConceptScore W2137861587C2778938600 @default.
• W2137861587 hasConceptScore W2137861587C2780561956 @default.
• W2137861587 hasConceptScore W2137861587C28406088 @default.
• W2137861587 hasConceptScore W2137861587C41625074 @default.
• W2137861587 hasConceptScore W2137861587C55493867 @default.
• W2137861587 hasConceptScore W2137861587C71924100 @default.
• W2137861587 hasConceptScore W2137861587C83743174 @default.
• W2137861587 hasConceptScore W2137861587C98274493 @default.
• W2137861587 hasLocation W21378615871 @default.
• W2137861587 hasLocation W21378615872 @default.
• W2137861587 hasOpenAccess W2137861587 @default.
• W2137861587 hasPrimaryLocation W21378615871 @default.
• W2137861587 hasRelatedWork W1965943749 @default.
• W2137861587 hasRelatedWork W2026105695 @default.
• W2137861587 hasRelatedWork W2028795934 @default.
• W2137861587 hasRelatedWork W2092630756 @default.
• W2137861587 hasRelatedWork W2102520192 @default.
• W2137861587 hasRelatedWork W2118751388 @default.
• W2137861587 hasRelatedWork W2132053570 @default.
• W2137861587 hasRelatedWork W2159859980 @default.
• W2137861587 hasRelatedWork W2891366938 @default.

• next