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• W2137863522 endingPage "3141" @default.
• W2137863522 startingPage "3136" @default.
• W2137863522 abstract "General mechanisms by which Hox genes establish cell fates are known. However, a few Hox effectors mediating cell behaviors have been identified. Here we found the first effector of LIN-39/HoxD4/Dfd in Caenorhabditis elegans. In specific vulval precursor cells (VPCs), LIN-39 represses early and late expression of EFF-1, a membrane protein essential for cell fusion. Repression of eff-1 is also achieved by the activity of CEH-20/Exd/Pbx, a known cofactor of Hox proteins. Unfused VPCs in lin-39(-);eff-1(-) double mutants fail to divide but migrate, executing vulval fates. Thus, lin-39 is essential for inhibition of EFF-1-dependent cell fusion and stimulation of cell proliferation during vulva formation. Supplemental material is available at http://www.genesdev.org." @default.
• W2137863522 created "2016-06-24" @default.
• W2137863522 creator A5013396870 @default.
• W2137863522 creator A5059576206 @default.
• W2137863522 date "2002-12-15" @default.
• W2137863522 modified "2023-09-23" @default.
• W2137863522 title "LIN-39/Hox triggers cell division and represses EFF-1/fusogen-dependent vulval cell fusion" @default.
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• W2137863522 doi "https://doi.org/10.1101/gad.251202" @default.
• W2137863522 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/187502" @default.
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• W2137863522 hasPublicationYear "2002" @default.
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