Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137907692> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2137907692 endingPage "007" @default.
- W2137907692 startingPage "001" @default.
- W2137907692 abstract "Circulating CD14+ monocytes originate from hematopietic stem cells and are believed to be committed precursors for phagocytes such as macrophages. Recently, we have reported a primitive human cell population called monocyte-derived multipotential cells (MOMCs), which has a fibroblast-like morphology in culture and a unique phenotype positive for CD14, CD45, CD34, and type I collagen. MOMCs are derived from circulating CD14+ monocytes, but circulating precursors still remain undetermined. MOMCs contain progenitors with the capacity to differentiate into a variety of mesenchymal cells in vitro, including bone, cartilage, fat, and skeletal and smooth muscles. Moreover, MOMCs are able to differentiate into the cardiomyogenic and neuronal lineage by co-culturing with primary cultures of embryonic heart and brain, respectively. In addition, MOMCs have capacity of differentiating into endothelium of a mature phenotype with typical morphologic, phenotypic, and functional characteristics. In vitro generation of MOMCs from precursors within circulating monocytes requires their binding to fibronectin and exposure to soluble factors derived from activated platelets. In a rat model of cerebral ischemia, transplantation of MOMCs into the ischemic core results in a significant improvement in neurologic function, but this effect is primarily due to neovascularization through production of a large array of angiogenic factors by MOMCs with some contribution of their differentiation into mature endothelial cells. These findings indicate that circulating CD14+ monocytes are involved in a variety of physiologic functions other than innate and acquired immune responses, such as repair and regeneration of the damaged tissue, through a variety of mechanisms." @default.
- W2137907692 created "2016-06-24" @default.
- W2137907692 creator A5066481817 @default.
- W2137907692 creator A5075788011 @default.
- W2137907692 date "2012-01-01" @default.
- W2137907692 modified "2023-10-12" @default.
- W2137907692 title "Potential involvement of human circulating CD14+ monocytes in tissue repair and regeneration" @default.
- W2137907692 cites W1487373628 @default.
- W2137907692 cites W1972713947 @default.
- W2137907692 cites W1987863585 @default.
- W2137907692 cites W1995044389 @default.
- W2137907692 cites W2027756860 @default.
- W2137907692 cites W2059341775 @default.
- W2137907692 cites W2061857614 @default.
- W2137907692 cites W2067731153 @default.
- W2137907692 cites W2078370392 @default.
- W2137907692 cites W2101566331 @default.
- W2137907692 cites W2104363348 @default.
- W2137907692 cites W2171650049 @default.
- W2137907692 doi "https://doi.org/10.2492/inflammregen.32.001" @default.
- W2137907692 hasPublicationYear "2012" @default.
- W2137907692 type Work @default.
- W2137907692 sameAs 2137907692 @default.
- W2137907692 citedByCount "1" @default.
- W2137907692 countsByYear W21379076922020 @default.
- W2137907692 crossrefType "journal-article" @default.
- W2137907692 hasAuthorship W2137907692A5066481817 @default.
- W2137907692 hasAuthorship W2137907692A5075788011 @default.
- W2137907692 hasBestOaLocation W21379076921 @default.
- W2137907692 hasConcept C171056886 @default.
- W2137907692 hasConcept C198826908 @default.
- W2137907692 hasConcept C201750760 @default.
- W2137907692 hasConcept C203014093 @default.
- W2137907692 hasConcept C2778513237 @default.
- W2137907692 hasConcept C28328180 @default.
- W2137907692 hasConcept C2908647359 @default.
- W2137907692 hasConcept C71924100 @default.
- W2137907692 hasConcept C86803240 @default.
- W2137907692 hasConcept C8891405 @default.
- W2137907692 hasConcept C95444343 @default.
- W2137907692 hasConcept C99454951 @default.
- W2137907692 hasConceptScore W2137907692C171056886 @default.
- W2137907692 hasConceptScore W2137907692C198826908 @default.
- W2137907692 hasConceptScore W2137907692C201750760 @default.
- W2137907692 hasConceptScore W2137907692C203014093 @default.
- W2137907692 hasConceptScore W2137907692C2778513237 @default.
- W2137907692 hasConceptScore W2137907692C28328180 @default.
- W2137907692 hasConceptScore W2137907692C2908647359 @default.
- W2137907692 hasConceptScore W2137907692C71924100 @default.
- W2137907692 hasConceptScore W2137907692C86803240 @default.
- W2137907692 hasConceptScore W2137907692C8891405 @default.
- W2137907692 hasConceptScore W2137907692C95444343 @default.
- W2137907692 hasConceptScore W2137907692C99454951 @default.
- W2137907692 hasIssue "1" @default.
- W2137907692 hasLocation W21379076921 @default.
- W2137907692 hasOpenAccess W2137907692 @default.
- W2137907692 hasPrimaryLocation W21379076921 @default.
- W2137907692 hasRelatedWork W1982205033 @default.
- W2137907692 hasRelatedWork W2037748539 @default.
- W2137907692 hasRelatedWork W2048957342 @default.
- W2137907692 hasRelatedWork W2062249760 @default.
- W2137907692 hasRelatedWork W2135793203 @default.
- W2137907692 hasRelatedWork W2161726790 @default.
- W2137907692 hasRelatedWork W2300366807 @default.
- W2137907692 hasRelatedWork W2766550637 @default.
- W2137907692 hasRelatedWork W2945552849 @default.
- W2137907692 hasRelatedWork W3213450778 @default.
- W2137907692 hasVolume "32" @default.
- W2137907692 isParatext "false" @default.
- W2137907692 isRetracted "false" @default.
- W2137907692 magId "2137907692" @default.
- W2137907692 workType "article" @default.