FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137923596> ?p ?o ?g. }

• W2137923596 endingPage "2333" @default.
• W2137923596 startingPage "2331" @default.
• W2137923596 abstract "Sorbitol dehydrogenase (SDH) is a polyol pathway enzyme that catalyzes conversion of sorbitol to fructose. Recent studies have demonstrated that activation of aldose reductase, the first enzyme of the polyol pathway, is a key response to ischemia and that inhibition of aldose reductase reduces myocardial ischemic injury. In our efforts to understand the role of pathway in affecting metabolism under normoxic and ischemic conditions, as well as in ischemic injury in myocardium, we investigated the importance of SDH by use of a specific inhibitor (SDI), CP-470,711. SDH inhibition increased glucose oxidation, whereas palmitate oxidation remained unaffected. Global ischemia increased myocardial SDH activity by approximately 1.5 fold. The tissue lactate/pyruvate ratio, a measure of cytosolic NADH/NAD+, was reduced by SDH inhibition under both normoxic and ischemic conditions. ATP was higher in SDI hearts during ischemia and reperfusion. Creatine kinase release during reperfusion, a marker of myocardial ischemic injury, was markedly attenuated in SDH-inhibited hearts. These data indicate that myocardial SDH activation is a component of ischemic response and that interventions that inhibit SDH protect ischemic myocardium. Furthermore, these data identify SDH as a novel target for adjunctive cardioprotective interventions." @default.
• W2137923596 created "2016-06-24" @default.
• W2137923596 creator A5006551245 @default.
• W2137923596 creator A5014233833 @default.
• W2137923596 creator A5048935619 @default.
• W2137923596 creator A5051573119 @default.
• W2137923596 creator A5069080430 @default.
• W2137923596 date "2003-10-02" @default.
• W2137923596 modified "2023-10-15" @default.
• W2137923596 title "Sorbitol dehydrogenase: a novel target for adjunctive protection of ischemic myocardium" @default.
• W2137923596 cites W1528838750 @default.
• W2137923596 cites W1546284669 @default.
• W2137923596 cites W174781154 @default.
• W2137923596 cites W1809955890 @default.
• W2137923596 cites W1938929291 @default.
• W2137923596 cites W1967818300 @default.
• W2137923596 cites W1997949901 @default.
• W2137923596 cites W2000887167 @default.
• W2137923596 cites W2004852379 @default.
• W2137923596 cites W2005077370 @default.
• W2137923596 cites W2015285866 @default.
• W2137923596 cites W202905722 @default.
• W2137923596 cites W2043505862 @default.
• W2137923596 cites W2048029040 @default.
• W2137923596 cites W2051835687 @default.
• W2137923596 cites W2052118876 @default.
• W2137923596 cites W2070927097 @default.
• W2137923596 cites W2073216357 @default.
• W2137923596 cites W2091291050 @default.
• W2137923596 cites W2099168978 @default.
• W2137923596 cites W2116699537 @default.
• W2137923596 cites W2124009251 @default.
• W2137923596 cites W2161604502 @default.
• W2137923596 cites W2169061609 @default.
• W2137923596 cites W2181988005 @default.
• W2137923596 cites W2233269311 @default.
• W2137923596 cites W2277770913 @default.
• W2137923596 cites W2310429071 @default.
• W2137923596 cites W2313159233 @default.
• W2137923596 cites W49292958 @default.
• W2137923596 doi "https://doi.org/10.1096/fj.03-0128fje" @default.
• W2137923596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14525943" @default.
• W2137923596 hasPublicationYear "2003" @default.
• W2137923596 type Work @default.
• W2137923596 sameAs 2137923596 @default.
• W2137923596 citedByCount "41" @default.
• W2137923596 countsByYear W21379235962012 @default.
• W2137923596 countsByYear W21379235962013 @default.
• W2137923596 countsByYear W21379235962014 @default.
• W2137923596 countsByYear W21379235962015 @default.
• W2137923596 countsByYear W21379235962016 @default.
• W2137923596 countsByYear W21379235962017 @default.
• W2137923596 countsByYear W21379235962018 @default.
• W2137923596 countsByYear W21379235962019 @default.
• W2137923596 countsByYear W21379235962021 @default.
• W2137923596 countsByYear W21379235962022 @default.
• W2137923596 countsByYear W21379235962023 @default.
• W2137923596 crossrefType "journal-article" @default.
• W2137923596 hasAuthorship W2137923596A5006551245 @default.
• W2137923596 hasAuthorship W2137923596A5014233833 @default.
• W2137923596 hasAuthorship W2137923596A5048935619 @default.
• W2137923596 hasAuthorship W2137923596A5051573119 @default.
• W2137923596 hasAuthorship W2137923596A5069080430 @default.
• W2137923596 hasConcept C126322002 @default.
• W2137923596 hasConcept C136502266 @default.
• W2137923596 hasConcept C165135838 @default.
• W2137923596 hasConcept C181199279 @default.
• W2137923596 hasConcept C185592680 @default.
• W2137923596 hasConcept C20251656 @default.
• W2137923596 hasConcept C2776317432 @default.
• W2137923596 hasConcept C2776439734 @default.
• W2137923596 hasConcept C2776779347 @default.
• W2137923596 hasConcept C2777318727 @default.
• W2137923596 hasConcept C2777905771 @default.
• W2137923596 hasConcept C2779311647 @default.
• W2137923596 hasConcept C2781272698 @default.
• W2137923596 hasConcept C541997718 @default.
• W2137923596 hasConcept C55493867 @default.
• W2137923596 hasConcept C71924100 @default.
• W2137923596 hasConcept C75520062 @default.
• W2137923596 hasConcept C88099638 @default.
• W2137923596 hasConcept C98274493 @default.
• W2137923596 hasConcept C98539663 @default.
• W2137923596 hasConceptScore W2137923596C126322002 @default.
• W2137923596 hasConceptScore W2137923596C136502266 @default.
• W2137923596 hasConceptScore W2137923596C165135838 @default.
• W2137923596 hasConceptScore W2137923596C181199279 @default.
• W2137923596 hasConceptScore W2137923596C185592680 @default.
• W2137923596 hasConceptScore W2137923596C20251656 @default.
• W2137923596 hasConceptScore W2137923596C2776317432 @default.
• W2137923596 hasConceptScore W2137923596C2776439734 @default.
• W2137923596 hasConceptScore W2137923596C2776779347 @default.
• W2137923596 hasConceptScore W2137923596C2777318727 @default.
• W2137923596 hasConceptScore W2137923596C2777905771 @default.
• W2137923596 hasConceptScore W2137923596C2779311647 @default.
• W2137923596 hasConceptScore W2137923596C2781272698 @default.
• W2137923596 hasConceptScore W2137923596C541997718 @default.
• W2137923596 hasConceptScore W2137923596C55493867 @default.

• next