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- W2137959306 abstract "Onchocercal keratitis (river blindness) is one of the leading worldwide causes of blindness. Light microscopic analysis of human speci-mens and corneal tissue from experimental models has implicated the eosin-ophil as an important cell in the inflammatory response. Our previous stud-ies in experimental murine onchocercal keratitis have demonstrated that the inflammatory infiltrate is composed primarily of eosinophils displaying ring shaped or bilobed nuclei. However, a number of cells were not character-izable by light microscopy, presumably due to mechanical distortion. To more fully characterize the inflammatory cell infiltrate, we examined corneal specimens by transmission electron microscopy. In addition to typical eosinophils with bilobed and ring shaped nuclei, this approach revealed cells with variable nuclear morphology and cell shape which contained the dense cored granules characteristic of eosinophils. Hence, the degree of pleomor-phsm of eosinophils is broader than appreciated and underscores the impor-tance of this cell in experimental murine onchocercal keratitis." @default.
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- W2137959306 date "1997-01-01" @default.
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- W2137959306 title "Pleomorphism of stromal eosinophils in murine experimental onchocercal keratitis" @default.
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- W2137959306 doi "https://doi.org/10.3109/09273949709116890" @default.
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