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- W2137973760 endingPage "208" @default.
- W2137973760 startingPage "199" @default.
- W2137973760 abstract "The low molecular weight GTP-binding protein RhoA regulates many cellular events, including cell migration, organization of the cytoskeleton, cell adhesion, progress through the cell cycle and gene expression. Physical forces influence these cellular processes in part by regulating RhoA activity through mechanotransduction of cell adhesion molecules (e.g. integrins, cadherins, Ig superfamily molecules). RhoA activity is regulated by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs) that are themselves regulated by many different signaling pathways. Significantly, the engagement of many cell adhesion molecules can affect RhoA activity in both positive and negative ways. In this brief review, we consider how RhoA activity is regulated downstream from cell adhesion molecules and mechanical force. Finally, we highlight the importance of mechanotransduction signaling to RhoA in normal cell biology as well as in certain pathological states. Keywords: Actin, adhesion, cytoskeleton, GTPase, force, mechanotransduction, RhoA." @default.
- W2137973760 created "2016-06-24" @default.
- W2137973760 creator A5011170871 @default.
- W2137973760 creator A5070642099 @default.
- W2137973760 creator A5088652924 @default.
- W2137973760 date "2014-02-01" @default.
- W2137973760 modified "2023-09-26" @default.
- W2137973760 title "Regulation of RhoA Activity by Adhesion Molecules and Mechanotransduction" @default.
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