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• W2137996940 abstract "Aggresomes are juxtanuclear inclusion bodies that have been proposed to represent a general cellular response to misfolded proteins in mammalian cells. Yet, why aggresomes are not a pathological characteristic of protein misfolding diseases is unclear. Here, we investigate if a misfolded protein inevitably forms aggresomes in mammalian cells.We show that a cytoplasmic form of the prion protein may form aggresomes or dispersed aggregates in different cell lines. In contrast to aggresomes, the formation of dispersed aggregates is insensitive to histone deacetylase 6 inhibitors and does not result in cytoskeleton rearrangements. Modulation of expression levels or proteasome inhibitors does not alter the formation of dispersed aggregates.Our results establish that aggresomes are not obligatory products of protein misfolding in vivo." @default.
• W2137996940 created "2016-06-24" @default.
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• W2137996940 date "2008-10-20" @default.
• W2137996940 modified "2023-09-23" @default.
• W2137996940 title "Aggresomes do not represent a general cellular response to protein misfolding in mammalian cells" @default.
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• W2137996940 doi "https://doi.org/10.1186/1471-2121-9-59" @default.
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