FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2137999917> ?p ?o ?g. }

• W2137999917 endingPage "402" @default.
• W2137999917 startingPage "393" @default.
• W2137999917 abstract "A plasmid that included both an 8.9 kb chromosomal DNA insert containing genes from the rfb cluster of Shigella dysenteriae 1 and a smaller insert containing the rfp gene from a S. dysenteriae 1 multicopy plasmid resulted in efficient expression of O antigen in an rfb-deleted strain of Escherichia coli K-12. Eight genes were identified in the rfb fragment: the rfbB-CAD cluster which encodes dTDP-rhamnose synthesis, rfbX which encodes a hydrophobic protein involved in assembly of the O antigen, rfc which encodes the O antigen polymerase, and two sugar transferase genes. The production of an O antigen also required the E. coli K-12 rfe gene, which is known to encode a transferase which adds N-acetylglucosamine phosphate to the carrier lipid undecaprenol phosphate. Thus Rfe protein appears to function as an analogue of the Salmonella RfbP protein to provide the first sugar of the O unit. Functional analysis of the other genes was facilitated by the fact that partial O units of one, two or three sugars were efficiently transferred to the lipopolysaccharide core. This analysis indicated that the plasmid-encoded Rfp protein is the transferase that adds the second sugar of the O unit while the two rfb transferases add the distal sugars to make an O antigen whose structure is (Rha-Rha-Gal-GlcNAc)n. The use of the rfe gene product as the transferase that adds the first sugar of an O unit is a novel mechanism which may be used for the synthesis of other enteric O antigens." @default.
• W2137999917 created "2016-06-24" @default.
• W2137999917 creator A5010386617 @default.
• W2137999917 creator A5047622161 @default.
• W2137999917 date "1993-07-01" @default.
• W2137999917 modified "2023-09-27" @default.
• W2137999917 title "Function of the rfb gene cluster and the rfe gene in the synthesis of O antigen by Shigella dysenteriae 1" @default.
• W2137999917 cites W1498110690 @default.
• W2137999917 cites W1500597578 @default.
• W2137999917 cites W1509519899 @default.
• W2137999917 cites W1520914849 @default.
• W2137999917 cites W1532413184 @default.
• W2137999917 cites W1550911355 @default.
• W2137999917 cites W1551351047 @default.
• W2137999917 cites W1588322133 @default.
• W2137999917 cites W1767527704 @default.
• W2137999917 cites W17824410 @default.
• W2137999917 cites W1804077545 @default.
• W2137999917 cites W1922098314 @default.
• W2137999917 cites W1924925857 @default.
• W2137999917 cites W1960373204 @default.
• W2137999917 cites W1971580990 @default.
• W2137999917 cites W1988661374 @default.
• W2137999917 cites W2017597673 @default.
• W2137999917 cites W2022533159 @default.
• W2137999917 cites W2032699324 @default.
• W2137999917 cites W2035883197 @default.
• W2137999917 cites W2055524924 @default.
• W2137999917 cites W2059655135 @default.
• W2137999917 cites W2073561238 @default.
• W2137999917 cites W2077320861 @default.
• W2137999917 cites W2111232268 @default.
• W2137999917 cites W2131891756 @default.
• W2137999917 cites W2133299692 @default.
• W2137999917 cites W2200572076 @default.
• W2137999917 cites W2263531331 @default.
• W2137999917 cites W2885814892 @default.
• W2137999917 doi "https://doi.org/10.1111/j.1365-2958.1993.tb01700.x" @default.
• W2137999917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7692219" @default.
• W2137999917 hasPublicationYear "1993" @default.
• W2137999917 type Work @default.
• W2137999917 sameAs 2137999917 @default.
• W2137999917 citedByCount "112" @default.
• W2137999917 countsByYear W21379999172012 @default.
• W2137999917 countsByYear W21379999172013 @default.
• W2137999917 countsByYear W21379999172015 @default.
• W2137999917 countsByYear W21379999172018 @default.
• W2137999917 countsByYear W21379999172019 @default.
• W2137999917 countsByYear W21379999172020 @default.
• W2137999917 countsByYear W21379999172021 @default.
• W2137999917 countsByYear W21379999172023 @default.
• W2137999917 crossrefType "journal-article" @default.
• W2137999917 hasAuthorship W2137999917A5010386617 @default.
• W2137999917 hasAuthorship W2137999917A5047622161 @default.
• W2137999917 hasConcept C104317684 @default.
• W2137999917 hasConcept C153911025 @default.
• W2137999917 hasConcept C181199279 @default.
• W2137999917 hasConcept C22744801 @default.
• W2137999917 hasConcept C2776376580 @default.
• W2137999917 hasConcept C2780610775 @default.
• W2137999917 hasConcept C36857842 @default.
• W2137999917 hasConcept C547475151 @default.
• W2137999917 hasConcept C55493867 @default.
• W2137999917 hasConcept C86803240 @default.
• W2137999917 hasConceptScore W2137999917C104317684 @default.
• W2137999917 hasConceptScore W2137999917C153911025 @default.
• W2137999917 hasConceptScore W2137999917C181199279 @default.
• W2137999917 hasConceptScore W2137999917C22744801 @default.
• W2137999917 hasConceptScore W2137999917C2776376580 @default.
• W2137999917 hasConceptScore W2137999917C2780610775 @default.
• W2137999917 hasConceptScore W2137999917C36857842 @default.
• W2137999917 hasConceptScore W2137999917C547475151 @default.
• W2137999917 hasConceptScore W2137999917C55493867 @default.
• W2137999917 hasConceptScore W2137999917C86803240 @default.
• W2137999917 hasIssue "2" @default.
• W2137999917 hasLocation W21379999171 @default.
• W2137999917 hasLocation W21379999172 @default.
• W2137999917 hasOpenAccess W2137999917 @default.
• W2137999917 hasPrimaryLocation W21379999171 @default.
• W2137999917 hasRelatedWork W1873683136 @default.
• W2137999917 hasRelatedWork W1969249387 @default.
• W2137999917 hasRelatedWork W2012379992 @default.
• W2137999917 hasRelatedWork W2037443437 @default.
• W2137999917 hasRelatedWork W2061778563 @default.
• W2137999917 hasRelatedWork W2106338079 @default.
• W2137999917 hasRelatedWork W2137999917 @default.
• W2137999917 hasRelatedWork W2147879470 @default.
• W2137999917 hasRelatedWork W2160727190 @default.
• W2137999917 hasRelatedWork W2350652591 @default.
• W2137999917 hasVolume "9" @default.
• W2137999917 isParatext "false" @default.
• W2137999917 isRetracted "false" @default.
• W2137999917 magId "2137999917" @default.
• W2137999917 workType "article" @default.